Results 71 to 80 of about 7,722 (193)

FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
A Bairoch, A Golovin, A Shulman-Peleg, A Stark, AC Martin, AG Murzin, AR Ortiz, B Rost, Benoît H. Dessailly, BH Dessailly, BJ Polacco, CA Orengo, Christine A. Orengo, CT Porter, D Lee, D Pal, DM Kristensen, E Krissinel, GA Reeves, HM Berman, Ian Sillitoe, IN Shindyalov, JA Gerlt, JD Watson, JM Chandonia, JM Sasin, K Kinoshita, L Aravind, L Holm, L Xie, L Xie, M Bashton, M Shatsky, MA Marti-Renom, ME Glasner, OC Redfern, OC Redfern, Oliver C. Redfern, PP Wangikar, R Apweiler, RA Laskowski, RA Laskowski, RL Marsden, Ruth Nussinov, S Wang, SF Altschul, TA Binkowski, Timothy J. Dallman, VA Ivanisenko, VA Ivanisenko, W Tian, WR Taylor, Y Ye   +52 more
core   +4 more sources

Defense strategies against sweet potato chlorotic stunt and pakakuy virus coinfection unraveled

Crop Science, Volume 64, Issue 6, Page 3438-3460, November/December 2024.
Abstract This study into the response of two Ipomoea batatas (L.) Lam cultivars, Melinda and Tio Joe, to coinfection with sweet potato chlorotic stunt virus (SPCSV) and sweet potato pakakuy virus (SPPV), employed a comprehensive approach encompassing symptomatology, real‐time quantitative polymerase chain reaction, metagenomics, and transcriptomics ...
Francis Wanjohi Kiemo, Pál Salamon, Zoltán Tóth, Zoltán Szabó   +3 more
wiley   +1 more source

The identity of the discriminator base has an impact on CCA addition [PDF]

, 2015
CCA-adding enzymes synthesize and maintain the C-C-A sequence at the tRNA 3''-end, generating the attachment site for amino acids. While tRNAs are the most prominent substrates for this polymerase, CCA additions on non-tRNA transcripts are described as ...
Betat, Heike, Bonin, Sonja, Götze, Oskar, Mörl, Mario, Wende, Sandra   +4 more
core   +1 more source

A comparative analysis of two conserved motifs in bacterial poly(A) polymerase and CCA-adding enzyme [PDF]

Showing a high sequence similarity, the evolutionary closely related bacterial poly(A) polymerases (PAP) and CCA-adding enzymes catalyze quite different reactions—PAP adds poly(A) tails to RNA 3′-ends, while CCA-adding enzymes synthesize the sequence CCA
A. Just, Aravind, Augustin, Bard, Betat, Bralley, Bryson, Chenna, F. Butter, H. Betat, Holm, Hou, Ingle, Kushner, Lizano, M. Morl, M. Trenkmann, Martin, MARTIN, Martin, McGann, McGuffin, Mohanty, O'Hara, Prasad, Raynal, Rost, Saraste, Schimmel, Schurer, Sch  rer, Shi, Sohlberg, Sprinzl, Sun, T. Heitkam, Tomita, Weiner, Williams, Yehudai-Resheff, Yue, Yue, Zhu   +42 more
core   +2 more sources

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

The emerging role of mtDNA release in sepsis: Current evidence and potential therapeutic targets

Journal of Cellular Physiology, Volume 239, Issue 11, November 2024.
Abstract Sepsis is a systemic inflammatory reaction caused by infection, and severe sepsis can develop into septic shock, eventually leading to multiorgan dysfunction and even death. In recent years, studies have shown that mitochondrial damage is closely related to the occurrence and development of sepsis.
Qianya Hong, Shuainan Zhu, Ying Yu, Yun Ren, Lin Jin, Huilin Wang, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

Biotechnological production of cyclic dinucleotides - challenges and opportunities [PDF]

, 2021
Cyclic dinucleotides (CDNs) are widely used secondary signaling molecules in prokaryotic and eukaryotic cells. As strong agonists of the stimulator of interferon genes, they are of great interest for pharmaceutical applications. In particular, cyclic-GMP-
Bartsch, Tabea, Becker, Martin, Lütz, Stephan, Rolf, Jascha, Rosenthal, Katrin   +4 more
core  

The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]

, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas, Drach, Kinoshita, Lim, Noguchi, Ohkura, Sazer, Suzuki   +7 more
core   +2 more sources

The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology [PDF]

, 2015
The interleukin enhancer binding factors ILF2 (NF45) and ILF3 (NF90/NF110) have been implicated in various cellular pathways, such as transcription, microRNA (miRNA) processing, DNA repair, and translation, in mammalian cells.
Badertscher, Lukas, Bammert, Lukas, Horváth, Péter, Koós, Krisztián, Montellese, Christian, Wandrey, Franziska   +5 more
core   +1 more source

A Mutation in the tRNA Nucleotidyltransferase Gene Promotes Stabilization of mRNAs in Saccharomyces cerevisiae [PDF]

, 1992
Stuart W. Peltz, Janet L. Donahue, Allan Jacobson   +2 more
openalex   +2 more sources