Results 71 to 80 of about 8,017 (202)

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, Volume 12, Issue 19, May 22, 2025.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Cytidines in tRNAs that are required intact by ATP/CTP:tRNA nucleotidyltransferases from Escherichia coli and Saccharomyces cerevisiae.

Nucleic Acids Research, 1990
Individual species of tRNA from Escherichia coli were treated with hydrazine/3 M NaCl to modify cytidine residues. The chemically modified tRNAs were used as substrate for ATP/CTP: tRNA nucleotidyltransferases from E.
L. A. Hegg, D. L. Thurlow
semanticscholar   +1 more source

Transcriptome atlas of Striga germination: Implications for managing an intractable parasitic plant

PLANTS, PEOPLE, PLANET, Volume 7, Issue 2, Page 396-410, March 2025.
Witchweeds, parasitic plants of the genus Striga, are nicknamed “cereal killers” because of their devastating destruction of Africa's most staple cereals, including maize, sorghum, millets, and upland rice. The parasite relies on biomolecules emitted from the host roots to germinate and therefore initiate its infectious lifecycle.
Gilles Irafasha, Sylvia Mutinda, Fredrick Mobegi, Brett Hale, George Omwenga, Asela J. Wijeratne, Susann Wicke, Emily S. Bellis, Steven Runo   +8 more
wiley   +1 more source

Capsular Typing and Molecular Characterization of Streptococcus agalactiae Strains Isolated From Bovine Mastitis in Iran

Veterinary Medicine and Science, Volume 11, Issue 2, March 2025.
The following three main findings were obtained from the present study: 1‐ The most common capsular serotype identified in Streptococcus agalactiae strains isolated from bovine mastitis cases was serotype Number III. 2‐ Most of the Streptococcus agalactiae strains isolated from bovine mastitis were antibiotic resistant to antibiotics commonly used in ...
Pegah HajiAhmadi, Hassan Momtaz, Elahe Tajbakhsh   +2 more
wiley   +1 more source

Ruminococcus gnavus in the gut: driver, contributor, or innocent bystander in steatotic liver disease?

The FEBS Journal, Volume 292, Issue 6, Page 1252-1264, March 2025.
Ruminococcus gnavus (R. gnavus) can degrade mucin, modify bile acids, and secrete metabolites into circulation via the portal vein to the liver for further processing and subsequent systemic circulation. R. gnavus is associated with metabolic syndrome and inflammatory bowel disease severity. It is suspected that R.
Vik Meadows, Jayson M. Antonio, Ronaldo P. Ferraris, Nan Gao   +3 more
wiley   +1 more source

Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer

Helicobacter, Volume 30, Issue 2, March/April 2025.
ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong, Krisana Asano, Junko Akada, Takashi Matsumoto, Akio Nakane, Yoshio Yamaoka   +5 more
wiley   +1 more source

Heterozygous PNPT1 Variants Cause a Sensory Ataxic Neuropathy

European Journal of Neurology, Volume 32, Issue 2, February 2025.
ABSTRACT Background Biallelic variants in polyribonucleotide‐nucleotidyltransferase‐1 (PNPT1) have been associated with a range of phenotypes from syndromic hearing loss to Leigh's syndrome. More recently, heterozygous variants in PNPT1, have been reported in three families with cerebellar ataxia and prominent sensory neuropathy.
Saif Haddad, Christopher J. Record, Eleanor Self, Mariola Skorupinska, Alexander M. Rossor, Matilde Laura, Gordon Ingle, Adnan Manzur, Francesco Muntoni, Julian C. Blake, Mary M. Reilly   +10 more
wiley   +1 more source

Transcription Kinetics in the Coronavirus Life Cycle

WIREs RNA, Volume 16, Issue 1, January/February 2025.
The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko, Ahmed Eisa Elhag, Tomasz Wojciech Turowski   +2 more
wiley   +1 more source

Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes

Traffic, Volume 26, Issue 1-3, January/March 2025.
TBK1 and its adaptor signaling play a crucial role in diverse biological processes, including innate immunity, selective autophagy, and mitosis. ABSTRACT The serine/threonine kinase, Tank Binding Kinase 1 (TBK1), drives distinct cellular processes like innate immune signaling, selective autophagy, and mitosis. It is suggested that the translocation and
Swagatika Paul, Sahitya Ranjan Biswas, Julia P. Milner, Porter L. Tomsick, Alicia M. Pickrell   +4 more
wiley   +1 more source

Possible homology between genes for two aminoglycoside nucleotidyltransferases, AAD(3'') and ANT(2''): an evolutionary relationship?

Journal of antibiotics (Tokyo. 1968), 1979
Sir: Four different plasmid-determined aminoglycoside nucleotidyltransferases have been identified in clinically isolated resistant bacteria. As seen in Fig.
M. Yagisawa, J. Davies
semanticscholar   +1 more source