Results 151 to 160 of about 525,575 (332)

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, Volume 13, Issue 6, 30 January 2026.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell

Neuron, 2019
Daniel C. Castro, M. Bruchas
semanticscholar   +1 more source

Six‐month follow‐up of ARIA‐H and iron deposition in real‐world lecanemab therapy for Alzheimer's disease: Evidence from a Chinese 7T MRI cohort

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION With the approval of lecanemab for treating Alzheimer's disease (AD), there is an urgent need to evaluate its safety and treatment effects on biomarkers in real‐world practice. METHODS Patients receiving lecanemab (n = 72) underwent routine 3T and 7T magnetic resonance imaging (MRI) for amyloid‐related imaging abnormality (ARIA ...
Weiwei Zhang, Haokun Liu, Cong Zhang, Yulai Li, Keying Fang, Yafang Zhou, Ling Weng, Liangjuan Fang, Yingying Luo, Han Xiao, Lin Zhou, Bin Jiao, Lu Shen   +12 more
wiley   +1 more source

Dopamine depletion in the nucleus accumbens of rats induced by a phenylalanine- and tyrosine-free amino acid mixture

, 2019
Sarah Taylor
openalex   +2 more sources

Investigation of Oxtr-expressing Neurons Projecting to Nucleus Accumbens using Oxtr-ires-Cre Knock-in prairie Voles (Microtus ochrogaster)

, 2020
Kengo Horie, Kiyoshi Inoue, Katsuhiko Nishimori, Larry J. Young   +3 more
openalex   +1 more source

Associations between metabolic syndrome and regional brain iron depositions and cognitive function in middle‐aged and older adults: A two multinational cohort study

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The alterations of regional brain iron in patients with metabolic syndrome (Mets) and its relationship with cognitive function remain unclear. METHODS These analyses utilized data from two prospective cohorts, from the UK Biobank (UKB) (21,346 participants) and from Jinan, China (224 participants). We capitalized brain iron in the
Xinyue Zhang, Linfeng Yang, Na Wang, Yuanyuan Wang, Qihao Zhang, Zhenyu Cheng, Yiwen Chen, Pengcheng Liang, Meng Li, Lingfei Guo, Changhu Liang   +10 more
wiley   +1 more source

Role of Rab10 in cocaine-induced behavioral effects is associated with GABAB receptor membrane expression in the nucleus accumbens [PDF]

Zhe Yu, Qiang Fu, Tianyun Qiu, Caidi Yang, Mingfen Lu, Qinghua Peng, Jianhua Yang, Zhenzhen Hu   +7 more
openalex   +1 more source

Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION It is unknown if neurodegeneration trajectories differ between Down syndrome (DS) and autosomal dominant Alzheimer's disease (ADAD), both of which are genetic forms of Alzheimer's disease (AD). METHODS We compared brain volumes in DS, ADAD, and unaffected family members serving as controls.
James T. Kennedy, Julie K. Wisch, Anna H. Boerwinkle, Peter R. Millar, Nicole S. McKay, Adam M. Brickman, Jasmeer P. Chhatwal, Patricio Chrem Mendez, Bradley T. Christian, Anne Cohen, Carlos Cruchaga, Alisha Daniels, Shaney Flores, Benjamin L. Handen, Sigan L. Hartley, Elizabeth Head, Laura Ibanez, Sharon J. Krisnsky‐McHale, Christian la Fougere, Florence Lai, Charles M. Laymon, Joseph H. Lee, Jae‐Hong Lee, Johannes Levin, Jorge Llibre‐Guerra, David F. Aguillon, Ira T. Lott, Mark Mapstone, Eric McDade, John Morris, Sid E. O'Bryant, Julie C. Price, Michael S. Rafii, Jee Hoon Roh, H. Diana Rosas, Nicole Schupf, Charlene Supnet‐Bell, Chengjie Xiong, Shahid Zaman, Tammie L. S. Benzinger, Brian A. Gordon, Beau M. Ances, the Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network   +43 more
wiley   +1 more source

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source