Results 31 to 40 of about 566,734 (334)
Dynamic risk control by human nucleus accumbens [PDF]
, 2015 Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed
Avecillas, J +9 more
core +1 more source
Reward behavior is regulated by the strength of hippocampus-nucleus accumbens synapses
Nature, 2018 Reward drives motivated behaviours and is essential for survival, and therefore there is strong evolutionary pressure to retain contextual information about rewarding stimuli. This drive may be abnormally strong, such as in addiction, or weak, such as in
T. LeGates +6 more
semanticscholar +1 more source
Dopamine restores reward prediction errors in old age. [PDF]
, 2013 Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value ...
Chowdhury, R +6 more
core +1 more source
The Nucleus Accumbens and Pavlovian Reward Learning [PDF]
The Neuroscientist, 2007 The ability to form associations between predictive environmental events and rewarding outcomes is a fundamental aspect of learned behavior. This apparently simple ability likely requires complex neural processing evolved to identify, seek, and use natural rewards and redirect these activities based on updated sensory information.
Jeremy J. Day, Regina M. Carelli
openaire +3 more sources
A multimodal neuroimaging classifier for alcohol dependence [PDF]
, 2020 With progress in magnetic resonance imaging technology and a broader dissemination of state-of-the-art imaging facilities, the acquisition of multiple neuroimaging modalities is becoming increasingly feasible.
Garbusow, Maria +13 more
core +2 more sources
Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats [PDF]
, 2016 Stress-induced reinstatement of cocaine seeking requires corticotropin releasing factor (CRF) actions in the ventral tegmental area (VTA). However the mechanisms through which CRF regulates VTA function to promote cocaine use are not fully understood ...
Baker, David A. +5 more
core +2 more sources
mGluR5 stimulates gliotransmission in the nucleus accumbens [PDF]
Proceedings of the National Academy of Sciences, 2007 Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc). Although mGluR5 has the potential to regulate neurons directly, recent studies have shown the importance of mGluR5 in
D'Ascenzo, Marcello +7 more
openaire +4 more sources
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
core +2 more sources
Nature Communications, 2018 Adolescence is a developmental period in which the mesolimbic dopaminergic “reward” circuitry of the brain, including the nucleus accumbens (NAc), undergoes significant plasticity. Dopamine D1 receptors (D1rs) in the NAc are critical for social behavior,
Ashley M. Kopec +4 more
semanticscholar +1 more source
Control of nucleus accumbens activity with neurofeedback [PDF]
NeuroImage, 2014 The nucleus accumbens (NAcc) plays critical roles in healthy motivation and learning, as well as in psychiatric disorders (including schizophrenia and attention deficit hyperactivity disorder). Thus, techniques that confer control of NAcc activity might inspire new therapeutic interventions. By providing second-to-second temporal resolution of activity
Stephanie M. Greer +3 more
openaire +3 more sources