Results 61 to 70 of about 525,575 (332)

Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats

Fiyz̤, 2019
Background: Cost-benefit decision-making is a one of the decision-making models in which the animal achieves a final benefit (reward) by evaluating the cost (effort or delay).
Saeedeh Nasrollahi, Sara Karimi, Alireza Abed , Gholamali Hamidi   +3 more
doaj  

Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core

International Journal of Neuropsychopharmacology, 2017
Background Drug cues recruit prelimbic cortex neurons that project to ipsilateral nucleus accumbens core. However, it is not known if the same is true for prelimbic cortex projections that decussate to innervate contralateral nucleus accumbens core ...
M. James, Ellen M McGlinchey, Asrita Vattikonda, S. Mahler, G. Aston-Jones   +4 more
semanticscholar   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity

Molecular Metabolism, 2019
Objective: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state ...
Melissa J. Chee, Alex J. Hebert, Nadege Briançon, Stephen E. Flaherty, III, Pavlos Pissios, Eleftheria Maratos-Flier   +5 more
doaj   +1 more source

Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia

IBRO Neuroscience Reports, 2023
Schizophrenia is a psychiatric disorder with a global prevalence of approximately 0.45%. It is considered a mental illness, with negative symptoms, positive symptoms, and cognitive dysfunction.
Gideon Opeyemi Ayilara, Bamidele Victor Owoyele   +1 more
doaj   +1 more source

Estrogen Receptor β in the Nucleus Accumbens Regulates the Rewarding Properties of Cocaine in Female Mice

International Journal of Neuropsychopharmacology, 2017
Background Females are more vulnerable to developing cocaine addiction compared with males, a phenomenon that may be regulated by the steroid hormone 17β-estradiol.
R. Satta, B. Certa, D. He, A. Lasek
semanticscholar   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Cocaine self-administration augments kappa opioid receptor system-mediated inhibition of dopamine activity in the mesolimbic dopamine system

IBRO Neuroscience Reports, 2023
Prior studies examining the effects of cocaine on the dynorphin/kappa opioid receptor (Dyn/KOR) system primarily focus on non-contingent cocaine exposure, but the effects of self-administration, which more closely reflects human drug-taking behaviors ...
Paige M. Estave, Haiguo Sun, Emily G. Peck, Katherine M. Holleran, Rong Chen, Sara R. Jones   +5 more
doaj   +1 more source

Decreased Nucleus Accumbens Expression of Psychiatric Disorder Risk Gene Cacna1c Promotes Susceptibility to Social Stress

International Journal of Neuropsychopharmacology, 2017
Background: Polymorphisms in the CACNA1C gene are associated with human mood disorders. The rodent social defeat model of stress/mood-disorder susceptibility results in maladaptive consequences mediated by altered function of mesolimbic circuits. Methods:
C. Terrillion, T. C. Francis, A. Puche, M. Lobo, T. Gould   +4 more
semanticscholar   +1 more source

Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology

Annals of Neurology, EarlyView.
The neurologist cares for patients with complex chronic conditions that compromise their wellbeing. Many such disorders are poorly understood. Whereas for some, effective symptomatic treatments exist, for most we lack an understanding of the molecular and cellular bases for disease pathogenesis needed for discovering disease‐modifying treatments ...
Fadel Zeidan, Joseph D. Stern, William C. Mobley   +2 more
wiley   +1 more source