Results 131 to 140 of about 482,535 (309)

Impact of Habitual Flexion on Bone Formation After Spinal Fusion Surgery: An In Silico Study

JOR SPINE, Volume 8, Issue 3, September 2025.
Lumbar spinal fusion is an effective treatment for spinal conditions, but non‐union remains a challenge due to unfavorable mechanical signals at the fusion site. This study used a computational model to investigate how habitual flexion loading affects bone fusion, finding that hybrid (compression + flexion) loading led to greater bone formation ...
Siddarth Ananth Swaminathan, Nima Taheri, Luis Becker, Matthias Pumberger, Hendrik Schmidt, Sara Checa   +5 more
wiley   +1 more source

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Scientific Reports, 2017
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular ...
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian   +7 more
doaj   +1 more source

Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression

BMC Musculoskeletal Disorders, 2011
Background The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus aging and (ii) as an appropriate ...
Gauthier Olivier, Fellah Borhane H, Lesoeur Julie, Masson Martial, Grimandi Gaël, Pot-Vaucel Marianne, Clouet Johann, Fusellier Marion, Cherel Yan, Maugars Yves, Guicheux Jérôme, Vinatier Claire   +11 more
doaj   +1 more source

Spatial and Diurnal Variations in Sodium Content Within Intervertebral Disc Tissue

JOR SPINE, Volume 8, Issue 3, September 2025.
Cycles of daily movement and nighttime relaxation create cycles in fixed charge density and tissue osmolarity in vivo. Previous measurements of these parameters have been limited by spatial resolution and an inability to measure in situ. This study develops and validates a novel application of laser ablation‐inductively coupled plasma‐mass spectrometry
Jordin T. Marshall, Anthony D. Lutton, Mark W. Grinstaff, John W. Olesik, Benjamin A. Walter   +4 more
wiley   +1 more source

Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane

Theranostics, 2019
Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration. In this study we explored the role of progerin in the pathogenesis of intervertebral disc degeneration (IDD).
Xiaolong Xu, Di Wang, Chao Zheng, Bo Gao, Jingzhou Fan, Pengzhen Cheng, Baohua Liu, Liu Yang, Zhuojing Luo   +8 more
semanticscholar   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]

, 2014
Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A., Breakwell, Lee M, Chiverton, Neil, Cole, Ashley A., Cross, Alison K., Le Maitre, Christine L., Michael, Anthony   +6 more
core   +2 more sources

Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration

JOR Spine
Background Condoliase is an enzyme used as a treatment for lumbar disc herniation (LDH). This enzyme degrades chondroitin sulfate (CS) in the nucleus pulposus of the intervertebral disc (IVD).
Yuka Minamisawa, Taiichi Shirogane, Ippei Watanabe, Akira Dezawa   +3 more
doaj   +1 more source

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells. [PDF]

, 2015
Objectives of this study were to investigate whether AQP1 and AQP5 expression is altered during intervertebral disc degeneration and if hypoxia and HIF-1 regulate their expression in NP cells.
Agre, Berl, Borok, Elliott, Frederiksen, Freemont, Gowin, Hassler, Hoi, Hoyland, Hoyland, Hu, Jiang, Kohen, Li, López-Barneo, Maroudas, Maroudas, Menon, Merrill, Mobasheri, Mort, Nielsen, Nishimura, Rafols, Risbud, Risbud, Risbud, Risbud, Risbud, Risbud, Risbud, Risbud, Risbud, Risbud, Roughley, Rudert, Saito, Schmid, Semenza, Shakibaei, Shapiro, Shapiro, Shapiro IM, Risbud, Shimoda, Tajkhorshid, Vaage, Wang, Wang, Wingham   +49 more
core   +3 more sources

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Cell Death and Disease, 2018
Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death of nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic effects in models of age-related degenerative
Jian Chen, Jun-jun Xie, Mengyun Jin, Yuntao Gu, Congcong Wu, Wei-Jun Guo, Ying-zhao Yan, Zeng-Jie Zhang, Jian-Le Wang, Xiao-Lei Zhang, Yan Lin, Jia-Li Sun, Guangyue Zhu, Xiang Wang, Yao S Wu   +14 more
semanticscholar   +1 more source