Results 131 to 140 of about 494,442 (303)
In vitro measurement of nucleus pulposus swelling pressure: A new technique for studies of spinal adaptation to gravity [PDF]
Swelling of the intervertebral disc nucleus pulposus is altered by posture and gravity. We have designed and tested a new osmometer for in vitro determination of nucleus pulposus swelling pressure.
Ballard, R. +7 more
core +1 more source
Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus
Advancement of science, 2019 Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels.
Wei Chen +8 more
semanticscholar +1 more source
The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma
The Journal of Pathology, Volume 266, Issue 3, Page 247-257, July 2025.Abstract The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were associated with chordomas and with the variant rs2305089 A‐allele with enrichment of the AA ...
Inga Usher +8 more
wiley +1 more source
Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms
Journal of Pineal Research, Volume 77, Issue 4, July 2025.ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2018 Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun +3 more
doaj
Cellular Physiology and Biochemistry, 2016 Background: Spinal degenerative diseases are a major health problem and social burden worldwide. Intervertebral disc degeneration (IDD) is the pathological basis of spinal degenerative diseases and is characterized by loss of nucleus pulposus cells due ...
Jin Feng Ma +4 more
doaj +1 more source
The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review. [PDF]
, 2014 Intervertebral disc (IVD) disorders are a major contributor to disability and societal health care costs. Nucleus pulposus (NP) cells of the IVD exhibit changes in both phenotype and morphology with aging-related IVD degeneration that may impact the ...
Chen, J +4 more
core +1 more source
Kaohsiung Journal of Medical Sciences, 2019 The present study determines whether the in vivo injection of TGFβ1 and CTGF mediated by AAV2 to transfect nucleus pulposus cells in degenerative lumbar discs can reverse the biological effects of rhesus lumbar disc degeneration.
Hua‐Cong Wang +6 more
doaj +1 more source
'Cell or Not to Cell' that is the question : for intervertebral disc regeneration? [PDF]
, 2017 Low back pain, strongly associated with intervertebral disc degeneration, is one of the most prevalent health problems in the western world today.
Le Maitre, Christine +2 more
core +1 more source
Theranostics, 2019 Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration. In this study we explored the role of progerin in the pathogenesis of intervertebral disc degeneration (IDD).
Xiaolong Xu +8 more
semanticscholar +1 more source