Results 21 to 30 of about 494,442 (303)

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs

Bone Research, 2021
A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) remains challenging.
Y. Gan, Jian He, Jun Zhu, Zhengyang Xu, Zhong Wang, Jing Yan, Ou Hu, Zhijie Bai, Lin Chen, Yangli Xie, M. Jin, Shuo Huang, Bing Liu, P. Liu   +13 more
semanticscholar   +1 more source

Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression

bioRxiv, 2021
Degeneration of the nucleus pulposus (NP) is a major contributor to intervertebral disc degeneration (IVDD) and low back pain. However, the underlying molecular complexity and cellular heterogeneity remain poorly understood.
Ji Tu, Wentian Li, Sidong Yang, Pengyi Yang, Qi Yan, Shenyu Wang, K. Lai, Xupeng Bai, Cenhao Wu, W. Ding, J. Cooper-White, A. Diwan, Cao Yang, Huilin Yang, J. Zou   +14 more
semanticscholar   +1 more source

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy

Stem Cells, 2021
Degeneration of the cartilage endplate (CEP) induces intervertebral disc degeneration (IVDD). Nucleus pulposus cell (NPC) apoptosis is also an important exacerbating factor in IVDD, but the cascade mechanism in IVDD is not clear.
Liwen Luo, Xiuying Jian, Hui Sun, Jinghao Qin, Yanqiu Wang, Ji Zhang, Zi-gang Shen, Di Yang, Chang‐qing Li, P. Zhao, Minghan Liu, Z. Tian, Yue Zhou   +12 more
semanticscholar   +1 more source

Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]

European Cells & Materials, 2021
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj   +1 more source

Acute Herniation of Nondegenerate Nucleus Pulposus [PDF]

Veterinary Clinics of North America: Small Animal Practice, 2018
Acute herniation of nondegenerate nucleus pulposus material is an important and relative common cause of acute spinal cord dysfunction in dogs. Two types of herniation of nondegenerate or hydrated nucleus pulposus have been recognized: acute noncompressive nucleus pulposus extrusion (ANNPE) and acute compressive hydrated nucleus pulposus extrusion ...
Joe Fenn, Steven De Decker
openaire   +3 more sources

Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling

Креативная хирургия и онкология, 2020
Background. With numerous extraction protocols for total RNA and RNA fractions, like microRNA (miRNA) and long non-coding RNA (lncRNA), available for various cell and tissue types, obtaining a high quantitative and qualitative yield from some special ...
I. F. Gareev, O. A. Beylerli, G. Yang, D. Zhang   +3 more
doaj   +1 more source

Kallistatin inhibits apoptosis and extracellular matrix degradation of human nucleus pulposus cells by inducing SIRT1 expression

陆军军医大学学报, 2022
Objective To investigate the effect of human tissue kallikrein-binding protein, kallistatin (KS) on intervertebral disc nucleus pulposus cells and the possible mechanism.
LU Enhu, LI Qingshu, TAN Yun
doaj   +1 more source

Exercise Restriction Does Not Change Outcome in Dogs After Diagnosis of Acute Non‐Compressive Nucleus Pulposus Extrusion, Fibrocartilaginous Embolism, or Hydrated Nucleus Pulposus Extrusion [PDF]

J Vet Intern Med
ABSTRACT Background Acute non‐compressive nucleus pulposus extrusion (ANNPE), fibrocartilaginous embolism (FCE), and hydrated nucleus pulposus extrusion (HNPE) all present with acute to peracute onset of myelopathic signs in dogs, for which treatment usually is medical.
Phillips K, Freeman P.
europepmc   +2 more sources

Hypoxia-induced expression of zinc finger protein A20 inhibits apoptosis and attenuates inflammation in nucleus pulposus cells

陆军军医大学学报, 2023
Objective To explore the effect and mechanism of zinc finger protein A20 in the nucleus pulposus cells of intervertebral disc with hypoxic conditions.
GUO Shuaichi, LIU Hao, HAN Zhenghan, LIU Wenjun, LIU Bo   +4 more
doaj   +1 more source

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]

, 2016
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous
Beltran, E, De Decker, S, Gomes, S A, Kenny, P J, Packer, R M A, Volk, H A   +5 more
core   +4 more sources