Results 21 to 30 of about 473,018 (289)

COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration. [PDF]

FASEB J
This study integrates single‐cell RNA sequencing, Mendelian randomization, and transcriptomics to investigate immune mechanisms in intervertebral disc degeneration. Single‐cell analysis of nucleus pulposus samples identified four major cell types. Mendelian randomization revealed key genes—COL6A1, LAPTM5, and ZFAND2A—associated with degeneration risk ...
Lu ZY, Chen PB, Xu QY, Mardan M, You MJ, Li B, Jiang SD, Jiang LS, Zheng XF.   +8 more
europepmc   +2 more sources

Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration

Cell Cycle, 2023
Intervertebral disc degeneration (IVDD), a widely known contributor to low back pain (LBP), has been proved to be a global health challenging conundrum. Hesperidin (hesperetin-7-O-rutinoside, HRD) is a flavanone glycoside that belongs to the subgroup of ...
Jian Zhu, Ruping Sun, Chen Yan, Kaiqiang Sun, Lu Gao, B. Zheng, Jian-gang Shi   +6 more
semanticscholar   +1 more source

MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. [PDF]

PLoS ONE, 2013
Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many pathological ...
Xin Yu, Zheng Li, Jianxiong Shen, William K K Wu, Jinqian Liang, Xisheng Weng, Guixing Qiu   +6 more
doaj   +1 more source

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Experimental and Molecular Medicine, 2022
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of
Weifeng Zhang, Gaocai Li, Rongjin Luo, J. Lei, Yu Song, Bingjin Wang, Liang Ma, Zhiwei Liao, Wencan Ke, Hui Liu, Wenbin Hua, K. Zhao, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Kun Wang, Cao Yang   +16 more
semanticscholar   +1 more source

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

Bone Research, 2022
Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major social and economic burdens; however, its underlying molecular mechanisms remain poorly defined.
Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, X. Bai, Sheng Liu, Yong-chao Wu, Mingjue Chen, Yuxiao Lai, Huiling Cao, Zengwu Shao, G. Xiao   +11 more
semanticscholar   +1 more source

Inducing Angiogenesis in the Nucleus Pulposus

Cells, 2023
Bone morphogenetic protein (BMP) gene delivery to Lewis rat lumbar intervertebral discs (IVDs) drives bone formation anterior and external to the IVD, suggesting the IVD is inhospitable to osteogenesis. This study was designed to determine if IVD destruction with a proteoglycanase, and/or generating an IVD blood supply by gene delivery of an angiogenic
Sheela R. Damle, Agata K. Krzyzanowska, Maximilian K. Korsun, Kyle W. Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A. Rawlins, Marjolein C. H. van der Meulen, Matthew B. Greenblatt, Chisa Hidaka, Matthew E. Cunningham   +11 more
openaire   +3 more sources

Damping properties of the nucleus pulposus [PDF]

Clinical Biomechanics, 2012
The nucleus pulposus is extremely deformable and it is not uncommon to observe strain amplitudes as large as 12.5% in physiological loading conditions. It has been shown that the nucleus pulposus contributes to the damping properties of the intervertebral disc.
Arne Vogel, Dominique P. Pioletti
openaire   +4 more sources

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

Cell Proliferation, 2021
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral ...
Guangzhi Zhang, Ming-Qiang Liu, Haiwei Chen, Zuolong Wu, Yicheng Gao, Zhanjun Ma, Xuegang He, X. Kang   +7 more
semanticscholar   +1 more source

HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy

Autophagy, 2021
Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD ...
Ruijun He, Zhe Wang, Min Cui, Sheng Liu, Wei Wu, Mo Chen, Yong-chao Wu, Yanji Qu, Hui Lin, Sheng Chen, Baichuan Wang, Zengwu Shao   +11 more
semanticscholar   +1 more source

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation

Frontiers in Pharmacology, 2022
Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu   +17 more
doaj   +1 more source