Results 21 to 30 of about 482,535 (309)

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

Bone Research, 2022
Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major social and economic burdens; however, its underlying molecular mechanisms remain poorly defined.
Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, X. Bai, Sheng Liu, Yong-chao Wu, Mingjue Chen, Yuxiao Lai, Huiling Cao, Zengwu Shao, G. Xiao   +11 more
semanticscholar   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi-Axial Perspective of Mechanical, Immune, and Metabolic Pathways. [PDF]

JOR Spine
The senescence of NPCs is at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back discomfort. ABSTRACT Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain.
Yang Y, Li H, Zuo J, Lei F.
europepmc   +2 more sources

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

Cell Proliferation, 2021
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral ...
Guangzhi Zhang, Ming-Qiang Liu, Haiwei Chen, Zuolong Wu, Yicheng Gao, Zhanjun Ma, Xuegang He, X. Kang   +7 more
semanticscholar   +1 more source

Damping properties of the nucleus pulposus [PDF]

Clinical Biomechanics, 2012
The nucleus pulposus is extremely deformable and it is not uncommon to observe strain amplitudes as large as 12.5% in physiological loading conditions. It has been shown that the nucleus pulposus contributes to the damping properties of the intervertebral disc.
Arne Vogel, Dominique P. Pioletti
openaire   +4 more sources

HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy

Autophagy, 2021
Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD ...
Ruijun He, Zhe Wang, Min Cui, Sheng Liu, Wei Wu, Mo Chen, Yong-chao Wu, Yanji Qu, Hui Lin, Sheng Chen, Baichuan Wang, Zengwu Shao   +11 more
semanticscholar   +1 more source

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation

Frontiers in Pharmacology, 2022
Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu   +17 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Frontiers in Cell and Developmental Biology, 2022
Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD). However, the cellular and molecular mechanisms involved remain elusive.
Zhencong Li, Dongping Ye, Libing Dai, Yude Xu, Hao Wu, Weihua Luo, Yiming Liu, X. Yao, Peigeng Wang, Haixiong Miao, Jiake Xu, Weiguo Liang   +11 more
semanticscholar   +1 more source

Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair

International Journal of Molecular Sciences, 2022
A growing body of evidence in humans and animal models indicates an association between intervertebral disc degeneration (IDD) and increased fibrotic elements in the nucleus pulposus (NP).
Yi Sun, Minmin Lyu, Qiujin Lu, Kenneth Cheung, V. Leung   +4 more
semanticscholar   +1 more source

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]

, 2002
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous
Beltran, E, De Decker, S, Gomes, S A, Kenny, P J, Packer, R M A, Volk, H A   +5 more
core   +4 more sources

Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m6A Modification of MAT2A Pre-mRNA by METTL16

Oxidative Medicine and Cellular Longevity, 2022
The process of intervertebral disc degeneration (IVDD) is complex, and its mechanism is considered multifactorial. Apoptosis of oxidative stressed nucleus pulposus cells (NPCs) should be a fundamental element in the pathogenesis of IVDD.
Peng-Bo Chen, Gui-Xun Shi, Tao Liu, Bo Li, Shengdan Jiang, Xinfeng Zheng, Lei-Sheng Jiang   +6 more
semanticscholar   +1 more source