Results 21 to 30 of about 18,806 (262)

MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. [PDF]

PLoS ONE, 2013
The precise role of apoptosis in the pathogenesis of intervertebral disc degeneration (IDD) remains to be elucidated. We analyzed degenerative nucleus pulposus (NP) cells and found that the expression of miR-27a was increased.
Gang Liu, Peng Cao, Huajiang Chen, Wen Yuan, Jianxi Wang, Xianye Tang   +5 more
doaj   +1 more source

Effect of hydrogel stiffness on nucleus pulposus cell phenotypes in vitro and its repairment of intervertebral disc in vivo

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effect of hydrogel stiffness on nucleus pulposus cell phenotype and its function in repairing intervertebral disc degeneration in rats.Methods·Methacrylate gelatin (GelMA) hydrogels with different concentrations were ...
CHEN Zehao, LÜ Zhendong, ZHANG Zhen, CUI Wenguo, ZHANG Yuhui   +4 more
doaj   +1 more source

LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis

European Journal of Medical Research, 2021
Background This study aimed to assess the role and mechanism of lncRNA NEAT1 in intervertebral disc degeneration (IVD). Methods LncRNA profile (GSE56081) between IVD and healthy control was downloaded from the Gene Expression Omnibus (GEO) database and ...
Cheng Li, Xinjian Ma, Chenfei Ni, Jingyan Xu, Yinfei Xie, Junwei Kan, Xiaoli Wei   +6 more
doaj   +1 more source

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence

Frontiers in Cell and Developmental Biology, 2022
Enhancer RNAs (eRNAs) are noncoding RNAs that synthesized at active enhancers. eRNAs have important regulatory characteristics and appear to be significant for maintenance of cell identity and information processing.
Yulin Huang, Jiaming Yang, Xizhe Liu, Xiaoshuai Wang, Kai Zhu, Zemin Ling, Baozhu Zeng, Ningning Chen, Shaoyu Liu, Fuxin Wei   +9 more
doaj   +1 more source

Scutellarin reduces apoptosis of nucleus pulposus cells in intervertebral disc degeneration of rat models [PDF]

Jichu yixue yu linchuang
Objective To investigate the effects of scutellarin (SCU) on apoptosis of nucleus pulposus cells and the Janus kinas 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in intervertebral disc degeneration (IVDD) model rats.
LI Na, ZHANG Peng, ZHANG Nan, LIN Wei, LIU Defeng, ZHENG Jihui
doaj   +1 more source

MR Imaging of Migrated Nucleus Pulposus after Collagenase Injection of Lumbar Disc Herniation: A Case Report

Journal of the Belgian Society of Radiology, 2022
Magnetic resonance images (MRI) of migrated nucleus pulposus after collagenase treatment of lumbar disc herniation are rarely published. Here, we describe a 65-year-old woman with L5-S1 intervertebral disc herniation on the rear left.
Bai Jin Tao Sun, Bing Li, Xu Feng, Han Feng Yang   +3 more
doaj   +1 more source

TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling

Cellular Physiology and Biochemistry, 2015
Background/Aims: Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG).
Bo Hu, Changgui Shi, Ye Tian, Ying Zhang, Chen Xu, Huajiang Chen, Peng Cao, Wen Yuan   +7 more
doaj   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Biomechanical Effects of Different Sitting Postures and Physiologic Movements on the Lumbar Spine: A Finite Element Study

Bioengineering, 2023
This study used the finite element method(FEM) to investigate how pressure on the lumbar spine changes during dynamic movements in different postures: standing, erect sitting on a chair, slumped sitting on a chair, and sitting on the floor.
Mingoo Cho, Jun-Sang Han, Sungwook Kang, Chang-Hwan Ahn, Dong-Hee Kim, Chul-Hyun Kim, Kyoung-Tae Kim, Ae-Ryoung Kim, Jong-Moon Hwang   +8 more
doaj   +1 more source

Cervical and Lumbar Herniated Nucleus Pulposus Resorption after Acupotomy with Integrative Korean Medicine Treatment: A Case Series of Two Patients [PDF]

Journal of Acupuncture Research, 2019
The aim of this study was to report on the resorption of herniated nucleus pulposus following acupotomy treatment. Two patients were treated with acupotomy which included integrative Korean Medicine treatment, for either cervical, or lumbar herniated ...
Ye Ji Lee, Jae Ik Kim, Hyo Bin Kim, Ju Hyun Jeon, Eunseok Kim, Young Il Kim   +5 more
doaj   +1 more source