Results 31 to 40 of about 473,018 (289)

Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair

International Journal of Molecular Sciences, 2022
A growing body of evidence in humans and animal models indicates an association between intervertebral disc degeneration (IDD) and increased fibrotic elements in the nucleus pulposus (NP).
Yi Sun, Minmin Lyu, Qiujin Lu, Kenneth Cheung, V. Leung   +4 more
semanticscholar   +1 more source

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Frontiers in Cell and Developmental Biology, 2022
Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD). However, the cellular and molecular mechanisms involved remain elusive.
Zhencong Li, Dongping Ye, Libing Dai, Yude Xu, Hao Wu, Weihua Luo, Yiming Liu, X. Yao, Peigeng Wang, Haixiong Miao, Jiake Xu, Weiguo Liang   +11 more
semanticscholar   +1 more source

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs

Bone Research, 2021
A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) remains challenging.
Y. Gan, Jian He, Jun Zhu, Zhengyang Xu, Zhong Wang, Jing Yan, Ou Hu, Zhijie Bai, Lin Chen, Yangli Xie, M. Jin, Shuo Huang, Bing Liu, P. Liu   +13 more
semanticscholar   +1 more source

Acute Herniation of Nondegenerate Nucleus Pulposus [PDF]

Veterinary Clinics of North America: Small Animal Practice, 2018
Acute herniation of nondegenerate nucleus pulposus material is an important and relative common cause of acute spinal cord dysfunction in dogs. Two types of herniation of nondegenerate or hydrated nucleus pulposus have been recognized: acute noncompressive nucleus pulposus extrusion (ANNPE) and acute compressive hydrated nucleus pulposus extrusion ...
Joe Fenn, Steven De Decker
openaire   +3 more sources

Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m6A Modification of MAT2A Pre-mRNA by METTL16

Oxidative Medicine and Cellular Longevity, 2022
The process of intervertebral disc degeneration (IVDD) is complex, and its mechanism is considered multifactorial. Apoptosis of oxidative stressed nucleus pulposus cells (NPCs) should be a fundamental element in the pathogenesis of IVDD.
Peng-Bo Chen, Gui-Xun Shi, Tao Liu, Bo Li, Shengdan Jiang, Xinfeng Zheng, Lei-Sheng Jiang   +6 more
semanticscholar   +1 more source

Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling

Креативная хирургия и онкология, 2020
Background. With numerous extraction protocols for total RNA and RNA fractions, like microRNA (miRNA) and long non-coding RNA (lncRNA), available for various cell and tissue types, obtaining a high quantitative and qualitative yield from some special ...
I. F. Gareev, O. A. Beylerli, G. Yang, D. Zhang   +3 more
doaj   +1 more source

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Journal of Orthopaedic Translation, 2023
Background: It has been demonstrated that vitamin D deficiency is associated with an increased risk of patients developing lumbar disc herniation. However, intervertebral disc degeneration caused by active vitamin D deficiency has not been reported. Thus,
Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao   +5 more
doaj   +1 more source

Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]

European Cells & Materials, 2021
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj   +1 more source

Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression

bioRxiv, 2021
Degeneration of the nucleus pulposus (NP) is a major contributor to intervertebral disc degeneration (IVDD) and low back pain. However, the underlying molecular complexity and cellular heterogeneity remain poorly understood.
Ji Tu, Wentian Li, Sidong Yang, Pengyi Yang, Qi Yan, Shenyu Wang, K. Lai, Xupeng Bai, Cenhao Wu, W. Ding, J. Cooper-White, A. Diwan, Cao Yang, Huilin Yang, J. Zou   +14 more
semanticscholar   +1 more source

Kallistatin inhibits apoptosis and extracellular matrix degradation of human nucleus pulposus cells by inducing SIRT1 expression

陆军军医大学学报, 2022
Objective To investigate the effect of human tissue kallikrein-binding protein, kallistatin (KS) on intervertebral disc nucleus pulposus cells and the possible mechanism.
LU Enhu, LI Qingshu, TAN Yun
doaj   +1 more source