Results 51 to 60 of about 473,018 (289)

MR Imaging of Migrated Nucleus Pulposus after Collagenase Injection of Lumbar Disc Herniation: A Case Report

Journal of the Belgian Society of Radiology, 2022
Magnetic resonance images (MRI) of migrated nucleus pulposus after collagenase treatment of lumbar disc herniation are rarely published. Here, we describe a 65-year-old woman with L5-S1 intervertebral disc herniation on the rear left.
Bai Jin Tao Sun, Bing Li, Xu Feng, Han Feng Yang   +3 more
doaj   +1 more source

Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

Journal of Cellular Physiology, 2020
Ferroptosis is a necrotic form of regulated cell death that was associated with lipid peroxidation and free iron‐mediated Fenton reactions. It has been reported that iron deficiency had been implicated in the pathogenesis of intervertebral disc ...
Run-Ze Yang, Wen-Ning Xu, Huo-Liang Zheng, Xinfeng Zheng, Bo Li, Lei-Sheng Jiang, Shengdan Jiang   +6 more
semanticscholar   +1 more source

Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration

Cell Proliferation, 2020
Lactate accumulation is an important factor in the intervertebral disc degeneration (IVDD). Currently, the effect and underlying mechanism of action of lactate on nucleus pulposus (NP) cell inflammation during IVDD are unclear.
K. Zhao, Ran An, Q. Xiang, Gaocai Li, Kun Wang, Yu Song, Zhiwei Liao, Shuai Li, Wenbin Hua, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Abhirup Das, Cao Yang   +13 more
semanticscholar   +1 more source

Genipin Cross-Linked Decellularized Nucleus Pulposus Hydrogel-Like Cell Delivery System Induces Differentiation of ADSCs and Retards Intervertebral Disc Degeneration

Frontiers in Bioengineering and Biotechnology, 2021
Intervertebral disc degeneration (IDD) is the pathological basis of disc degenerative diseases (DDD). Reduction in the number of cells and degeneration of the extracellular matrix (ECM) in the nucleus pulposus (NP) are characteristics of IDD.
Lei Yu, Yi Liu, Jianxin Wu, Shuang Wang, Jiangming Yu, Weiheng Wang, X. Ye   +6 more
semanticscholar   +1 more source

Cell sources for nucleus pulposus regeneration [PDF]

European Spine Journal, 2013
There is increasing interest in the development of cell therapy as a possible approach for the treatment of degenerative disc disease. To regenerate nucleus pulposus tissue, the cells must produce an appropriate proteoglycan-rich matrix, as this is essential for the functioning of the intervertebral disc. The natural environment within the disc is very
Kregar Velikonja, N, Urban, J, Fröhlich, M, Neidlinger-Wilke, C, Kletsas, D, Potocar, U, Turner, S, Roberts, S   +7 more
openaire   +3 more sources

TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling

Cellular Physiology and Biochemistry, 2015
Background/Aims: Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG).
Bo Hu, Changgui Shi, Ye Tian, Ying Zhang, Chen Xu, Huajiang Chen, Peng Cao, Wen Yuan   +7 more
doaj   +1 more source

Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF‐1α–BNIP3 Axis

Journal of Bone and Mineral Research, 2020
Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the intervertebral disc and are predominantly glycolytic due to robust HIF‐1 activity.
Vedavathi Madhu, Paige K Boneski, Elizabeth S. Silagi, Yunping Qiu, I. Kurland, A. Guntur, I. Shapiro, M. Risbud   +7 more
semanticscholar   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells

Aging, 2020
Intervertebral disc degeneration (IDD) is characterized by the decrease of nucleus pulposus cells (NPCs). With the increase of the degree of degeneration, the reactive oxygen species (ROS) in nucleus pulposus tissue increases.
Zhibiao Bai, Wei Liu, Danshuang He, Yiyang Wang, Weiwei Yi, Chan Luo, Jieliang Shen, Zhenming Hu   +7 more
semanticscholar   +1 more source

Biomechanical Effects of Different Sitting Postures and Physiologic Movements on the Lumbar Spine: A Finite Element Study

Bioengineering, 2023
This study used the finite element method(FEM) to investigate how pressure on the lumbar spine changes during dynamic movements in different postures: standing, erect sitting on a chair, slumped sitting on a chair, and sitting on the floor.
Mingoo Cho, Jun-Sang Han, Sungwook Kang, Chang-Hwan Ahn, Dong-Hee Kim, Chul-Hyun Kim, Kyoung-Tae Kim, Ae-Ryoung Kim, Jong-Moon Hwang   +8 more
doaj   +1 more source