Results 51 to 60 of about 494,442 (303)

In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration. [PDF]

JOR Spine
Although precise pathophysiological mechanisms remain elusive, perturbations in nutrition that adversely impact the cellular microenvironment of the central nucleus pulposus (NP) are considered key contributors to disc degeneration. In this study, we adapted brain tissue oxygen probes and microdialysis catheters for in situ determination of NP tissue ...
Rajagopal K, Schaer TP, Meadows KD, Boyes M, Hilliard R, O'Donnell JC, Dodge GR, Petrov D, Elliott DM, Mauck RL, Smith LJ, Malhotra NR.   +11 more
europepmc   +2 more sources

Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique. [PDF]

JOR Spine
The current study improves cyber toxicology as a method of evaluating environmental toxicity and molecular biological qualities in addition to clarifying the possible molecular pathways of nicotine‐induced senescence in IVDD. ABSTRACT Aim Through the use of network toxicology, the research sought to determine whether cellular senescence and associated ...
Jiang C, Song C, Chen C, Shen B, Yang L, Zhang C, Liu F, Wu X, Chen F.   +8 more
europepmc   +2 more sources

Cell sources for nucleus pulposus regeneration [PDF]

European Spine Journal, 2013
There is increasing interest in the development of cell therapy as a possible approach for the treatment of degenerative disc disease. To regenerate nucleus pulposus tissue, the cells must produce an appropriate proteoglycan-rich matrix, as this is essential for the functioning of the intervertebral disc. The natural environment within the disc is very
Kregar Velikonja, N, Urban, J, Fröhlich, M, Neidlinger-Wilke, C, Kletsas, D, Potocar, U, Turner, S, Roberts, S   +7 more
openaire   +3 more sources

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells

Aging, 2020
Intervertebral disc degeneration (IDD) is characterized by the decrease of nucleus pulposus cells (NPCs). With the increase of the degree of degeneration, the reactive oxygen species (ROS) in nucleus pulposus tissue increases.
Zhibiao Bai, Wei Liu, Danshuang He, Yiyang Wang, Weiwei Yi, Chan Luo, Jieliang Shen, Zhenming Hu   +7 more
semanticscholar   +1 more source

TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model. [PDF]

JOR Spine
TNFα receptor‐specific signaling is important in rat IVDD in vivo and in vitro. TNFR1 inhibition was more effective with small molecules than with blocking antibodies. Low levels of TNFR2 in rat AF and NP cells, and the lack of efficacy of TNFR2‐activator Atsttrin, suggest that native AF and NP cells have little capacity for TNFR2‐dependent IVD repair.
Jacobsen TD, Yiantsos SO, Gansau J, Meyers J, Laudier D, Iatridis JC.   +5 more
europepmc   +2 more sources

Experimental Conference Summary [PDF]

Nucl.Phys. A698 (2002) 341-359, 2001
Experimental summary talk given at International Conference on Ultrarelativistic Nucleus-Nucleus Collisions (QM2001), Stony Brook, New York, 15-20 Jan 2001.
arxiv   +1 more source

Equine cervical intervertebral disc degeneration is associated with location and MRI features [PDF]

, 2019
Morphology of the equine cervical intervertebral disc is different from that in humans and small companion animals and published imaging data are scarcely available.
Back, Willem, Bergmann, Wilhelmina, Nielen, Mirjam, van den Belt, Antoon-Jan M., Veraa, Stefanie, Vernooij, Hans, Wijnberg, Inge D.   +6 more
core   +1 more source

Single and double inclusive cross-sections for nucleus-nucleus collisions in the peryrbative QCD [PDF]

Eur.Phys.J.C55:377-386,2008, 2008
Single and double inclusive cross-sections in nucleus-nucleus collisions are derived in the perturbative QCD with interacting BFKL pomerons in the quasi-classical approximation.
arxiv   +1 more source

Clinical reasoning in canine spinal disease: what combination of clinical information is useful? [PDF]

, 2015
Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the
ABRAMSON, ARMAŞU, AWANO, BAGLEY, BESALTI, BRISSON, DA COSTA, DA COSTA, DA COSTA, DE DECKER, DE RISIO, DE RISIO, DE RISIO, DELAMAIDE GASPER, DRIVER, GANDINI, HOLDER, JEFFERY, JULL, KRANENBURG, LANE, LEVINE, LU, MAY, MCKEE, MEIJ, PALUS, PARENT, PARK, RUSBRIDGE, RUSBRIDGE, SCHMIDT, TABACHNICK, TIPOLD, TIPOLD, VAN WIE, ZENG   +36 more
core   +2 more sources

Model for compound nucleus formation in various heavy-ion systems [PDF]

arXiv, 2023
The statistical model for the calculation of the compound nucleus formation cross section and the probability of compound nucleus formation in heavy-ion collisions is discussed in detail. The light, heavy, and super-heavy nucleus-nucleus systems are considered in this model in the framework of one approach.
arxiv