Results 51 to 60 of about 12,671,316 (204)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Number representation in the parietal lobes [PDF]
, 2002 This thesis considers the importance of the inferior parietal lobe for calculation and Arabic number comparison. The first experiment demonstrates that repetitive Transcranial Magnetic Stimulation (rTMS) can be used on normal subjects to replicate ...
Göbel, Silke M., Göbel, Silke.
core +1 more source
Frontiers in Psychology, 2018 Spatial representations of number, such as a left-to-right oriented mental number line, are well documented in Western culture. Yet, the functional significance of such a representation remains unclear.
Lauren S. Aulet, Stella F. Lourenco
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Journal of CognitionThe approximate number system (ANS) is thought to mediate symbolic and non-symbolic numerical magnitude comparison. Challenging this view, the dual system model stipulates that non-symbolic comparisons rely on the ANS while symbolic comparisons rely on a
Alexis Garsmeur +2 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Bisecting the mental number line in near and far space [PDF]
, 2010 Much evidence suggests that common posterior parietal mechanisms underlie the orientation of attention in physical space and along the mental number line.
Longo, Matthew R. +3 more
core +1 more source
, 2018 This research examines whether a common magnitude approximation system represents magnitude information and informs magnitude related judgements in adults.
Waring, Rylan
core +1 more source
Fraction Magnitude: Mapping Between Symbolic and Spatial Representations of Proportion
Journal of Numerical Cognition, 2020 Fraction notation conveys both part-whole (3/4 is 3 out of 4) and magnitude (3/4 = 0.75) information, yet evidence suggests that both children and adults find accessing magnitude information from fractions particularly difficult. Recent research suggests
Michelle Ann Hurst +2 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source