Results 91 to 100 of about 1,111,078 (255)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Development of Nugle (Numerical Guide for Learning) Mobile Learning Media to Improve Students’ Number Sense in State Islamic Junior High Schools

open access: yesMaPan: Jurnal Matematika dan Pembelajaran
Mathematics is a fundamental discipline that supports problem-solving in daily life, particularly through number sense, which enables students to understand and reason flexibly with numerical concepts. However, research indicates that Indonesian students’
Wahyuni Fajar Arum   +2 more
doaj   +1 more source

Exploring Number Sense in Students with Dyslexia, Dyscalculia, and Dysgraphia [PDF]

open access: yesHuman Research in Rehabilitation
This study examines number sense in students formally diagnosed with dyslexia, dyscalculia, and dysgraphia - specific learning difficulties that do not impact intelligence but affect reading, writing, and calculation.
Tatjana Kovacevic   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Exploring pre-service teachers’ knowledge of efficient calculation strategies

open access: yesSouth African Journal of Childhood Education
Background: National and international assessments show South Africa’s underperformance in mathematics. As many learners already fall behind in the early grades, where foundational number sense should be established, addressing the challenges of number ...
Marisa Kumm, Mellony H. Graven
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Visual number sense for real-world scenes shared by deep neural networks and humans. [PDF]

open access: yesHeliyon, 2023
Wencheng W   +5 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Role of Lateral Inhibition on Visual Number Sense. [PDF]

open access: yesFront Comput Neurosci, 2022
Zhou Y, Chen H, Wang Y.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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