Results 41 to 50 of about 23,701 (235)
Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Coumarins were discovered to act as inhibitors of α-carbonic anhydrases (CAs, EC 4.2.1.1) after undergoing hydrolysis mediated by the esterase activity of the enzyme to the corresponding 2-hydroxycinnamic acids.
Simone Giovannuzzi +4 more
doaj +1 more source
Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms of overcoming the limitations of facile chemical synthesis, increased ...
Andrea Angeli, Claudiu T. Supuran
doaj +1 more source
Solid lipid nanoparticles as oral delivery systems of phenolic compounds: overcoming pharmacokinetic limitations for nutraceutical applications [PDF]
, 2017 Drug delivery systems, accompanied by nanoparticle technology, have recently emerged as prominent solutions to improve the pharmacokinetic properties, namely bioavailability, of therapeutic and nutraceutical agents.
Campos, Débora +6 more
core +1 more source
NMR in Nutraceutical and Functional Foods [PDF]
, 2014 NMR in Nutraceutical and Functional ...
RANDAZZO, ANTONIO
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In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Discover FoodPlantain has been used in folklore for the management of diabetes and hypertension. The locals either make whole unripe plantain fruits into wet slurry or powdered form.
Odunayo Michael Agunloye +3 more
doaj +1 more source
NutraceuticalsThere was an error in the original publication [...]
Allyson Davis +2 more
doaj +1 more source
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII).
Aleksandrs Pustenko +6 more
doaj +1 more source
CMFRI develops anti-obesity nutraceutical from seaweeds The Hindu Business Line dated 16th February 2017 [PDF]
, 2017 Central Marine Fisheries Research Institute has developed an anti-obesity nutraceutical from seaweeds. The product named Cadalmin Antihypercholesterolemic extract (Cadalmin ACe) is a natural remedy for obesity and dyslipidemia. CMFRI scientists prepared
CMFRI, Library
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Advanced Science, EarlyView.ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen +18 more
wiley +1 more source