Results 131 to 140 of about 520,936 (312)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Analysis of Nitrogen Loading Reductions for Wastewater Treatment Facilities and Non-Point Sources in the Great Bay Estuary Watershed [PDF]

open access: yes, 2010
In 2009, the New Hampshire Department of Environmental Services (DES) published a proposal for numeric nutrient criteria for the Great Bay Estuary. The report found that total nitrogen concentrations in most of the estuary needed to be less than 0.3 mg N/
Burack, Thomas S.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Optimization of Chemical Defined Medium for Lactobacillus brevis Based on Artificial Intelligence

open access: yesEngineering in Life Sciences
Lactobacillus brevis (L. brevis) is a bacterium known for its lactic acid production and probiotic properties. However, the limited research on industrial fermentation of L. brevis and its low productivity pose challenges.
Chang Yu   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Nutrient requirements and evaluation of equations to predict chemical body composition of dairy crossbred steers. [PDF]

open access: yesAnim Biosci, 2021
Silva FAS   +6 more
europepmc   +1 more source

How Baywide Nutrient Trading Could Benefit Pennsylvania Farms [PDF]

open access: yes, 2010
Outlines how legislation to make the Chesapeake Bay watershed healthier, including a program allowing farms that reduce runoff of nutrients to below target to sell "credits," would benefit Pennsylvania farms through cost-sharing funds and new ...
Cy Jones   +4 more
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Impacts of Maternal Nutrition on Sow Performance and Potential Positive Effects on Piglet Performance

open access: yesAnimals
The objectives of this review are to identify the nutritional challenges faced by modern sows and present potential solutions to mitigate excessive maternal tissue loss and reproductive failure as it relates to recent genetic improvements.
Alexa Gormley   +4 more
doaj   +1 more source

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