Results 51 to 60 of about 220,349 (300)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Food supply, nutrition and trade policy: reversal of an import ban on turkey tails

Bulletin of the World Health Organization, 2017
Turkey tails are a cheap, fatty meat, imported into many developing countries. The Government of Samoa implemented an import ban on turkey tails in 2007 as part of its efforts to reduce noncommunicable diseases in the country. (1) The population of Samoa has some of the highest rates of noncommunicable diseases in the world: in 2013, diabetes ...
Thow, Anne Marie, Reeve, Erica, Naseri, Take, Martyn, Tim, Bollars, Caroline   +4 more
openaire   +4 more sources

Changing pattern of malaria in Bissau, Guinea Bissau.

, 2008
OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country.
Aaby, Peter, Greenwood, Brian, Kofoed, Poul-Erik, Rodrigues, Amabelia, Schellenberg, Joanna Armstrong   +4 more
core   +1 more source

Quality and Safety Aspects of Infant Nutrition [PDF]

, 2012
Quality and safety aspects of infant nutrition are of key importance for child health, but oftentimes they do not get much attention by health care professionals whose interest tends to focus on functional benefits of early nutrition.
Agostoni C, Agostoni C, Agostoni C, Aris B, Berthold Koletzko, Bier DM, Birlouez-Aragon I, Bonerba E, Cahill SM, Chang H, Dabeka R, Davanzo R, Day JB, Dewey KG, Domellof M, El-Tras WF, Erkekoglu P, Fattal-Valevski A, Fattal-Valevski A, Fattal-Valevski A, Fewtrell MS, Fewtrell MS, Flores JP, Friedman M, Gossner CM, Guzel A, Hamrin P, Hernell O, Hilbig A, Hirvonen T, Jongenburger I, Kaleita TA, Khlangwiset P, Kim SA, Koletzko B, Koletzko B, Koletzko B, Kornreich L, Kvist LJ, Lanska DJ, Lönnerdal B, Malloy MH, Margaret Ashwell, Miled RB, Mitkus RJ, Newberry RE, Norberg S, Oluwafemi F, Panfeng S, Pavesi Arisseto A, Raanan Shamir, Raecker T, Rebhan B, Reij MW, Ruiz E, Santillana MI, Schoder D, Shamir R, Silver LB, Simoneau C, Simoneau C, Snijder CA, Snijder CA, Szajewska H, Szajewska H, Turck D, Weistaub G, Welch RW, Whyatt RM, Willoughby A, Yen TH, Zlotkin S   +71 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Food safety and nutrition for low-income urbanites: exploring a social justice dilemma in consumption policy

Regional Environmental Change, 2019
Equitable access to healthy food is a critical challenge in urban Asia. Food safety governance promotes modern supermarkets over more traditional markets, but supermarkets are associated with unequal access to food.
Sigrid C. O. Wertheim-Heck, J. Raneri, P. Oosterveer   +2 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Nutrition and the Food Supply: Controversies and Prospects

The American Biology Teacher, 1976
THERE SEEM TO BE two opposing views on the question of supplying people with food. The first cites the example of Bangladesh and other countries where starvation seems inevitable, and states that it is useless or even counterproductive to prevent people in such countries from starving.
openaire   +1 more source