Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity
Biomedicines, 2021 The incidence of obesity has dramatically increased over the last decades. Recently, there has been a growing interest in the possible association between the pandemics of obesity and some endocrine-disrupting chemicals (EDCs), termed “obesogens”.
Immacolata Cristina Nettore +4 more
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In utero DDT and DDE exposure and obesity status of 7-year-old Mexican-American children in the CHAMACOS cohort. [PDF]
, 2013 BackgroundIn utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life.ObjectivesThe Center for the Health ...
Aguilar Schall, Raul +5 more
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Biomedicines, 2021 The functions of anorexigenic neurons secreting proopiomelanocortin (POMC)/alpha-melanocyte-stimulating hormone (α-MSH) of the melanocortin system in the hypothalamus in vertebrates are energy homeostasis, food intake, and body weight regulation. However,
Yang-Wen Hsieh +5 more
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Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups [PDF]
, 2018 Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife.
Bennett, Kimberley A. +5 more
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Endocrine Aspects of Environmental "Obesogen" Pollutants [PDF]
, 2016 Growing evidence suggests the causal link between the endocrine-disrupting chemicals (EDCs) and the global obesity epidemics, in the context in the so-called "obesogenic environment".
Barrea, Luigi +6 more
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Associations of PON1 and genetic ancestry with obesity in early childhood. [PDF]
, 2013 Obesity in children has become an epidemic in the U.S. and is particularly prominent in minority populations such as Mexican-Americans. In addition to physical activity and diet, genetics also plays a role in obesity etiology. A few studies in adults and
Beckman, Kenneth +4 more
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Endocrine Disrupting Chemicals: An Occult Mediator of Metabolic Disease
Frontiers in Endocrinology, 2019 Endocrine disrupting chemicals (EDCs), a heterogeneous group of exogenous chemicals that can interfere with any aspect of endogenous hormones, represent an emerging global threat for human metabolism.
Olga Papalou +3 more
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Toxics, 2022 Persistent organic pollutants (POPs) are considered as potential obesogens that may affect adipose tissue development and functioning, thus promoting obesity. However, various POPs may have different mechanisms of action.
Jan Aaseth +7 more
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Zebrafish as a model to study the role of Peroxisome Proliferating-Activated Receptors in adipogenesis and obesity [PDF]
, 2015 The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis.
Den Broeder, MJ +3 more
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Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47 [PDF]
, 2014 Recent studies suggest that exposure to endocrine-disrupting compounds (EDCs) may play a role in the development of obesity. EDCs such as the flame retardant 2,2′,4,4′-tetrabrominated diphenyl ether (BDE-47) have been shown to enhance adipocyte ...
Blumberg, B +6 more
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