Results 31 to 40 of about 1,065 (167)
Frontiers in Toxicology, 2023 In past times, the analysis of endocrine disrupting properties of chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well as on aspects of steroidogenesis and the modulation of thyroid signaling.
Albert Braeuning +18 more
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Transgenerational effects of obesogens
Basic & Clinical Pharmacology & Toxicology, 2019 AbstractObesity and associated disorders are now a global pandemic. The prevailing clinical model for obesity is overconsumption of calorie‐dense food and diminished physical activity (the calories in—calories out model). However, this explanation does not account for numerous recent research findings demonstrating that a variety of environmental ...
Lee, Michelle Kira, Blumberg, Bruce
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Pesticides and Male Fertility: A Dangerous Crosstalk
Metabolites, 2021 In recent decades, an increasing incidence of male infertility has been reported. Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these
Sílvia Moreira +5 more
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Obesogenic environment and childhood obesity [PDF]
Obesity Reviews, 2020 SummaryThe increasing prevalence of obesity in youth has contributed to the growing global burden of chronic diseases (e.g. diabetes, cardiovascular diseases and cancers), which has been largely accounted for by obesogenic behaviours and environments.
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Minireview: PPARγ as the target of obesogens [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 The peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis and is medically important for its connections to obesity and the treatment of type II diabetes. Activation of this receptor by certain natural or xenobiotic compounds has been shown to stimulate adipogenesis in vitro and in vivo.
Amanda, Janesick, Bruce, Blumberg
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Current Research Approaches and Challenges in the Obesogen Field
Frontiers in Endocrinology, 2019 Obesity is a worldwide pandemic that also contributes to the increased incidence of other diseases such as type 2 diabetes. Increased obesity is generally ascribed to positive energy balance.
Raquel Chamorro-Garcia +3 more
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Toxics, 2022 Persistent organic pollutants (POPs) are considered as potential obesogens that may affect adipose tissue development and functioning, thus promoting obesity. However, various POPs may have different mechanisms of action.
Jan Aaseth +7 more
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Globalization and modernization: an obesogenic combination [PDF]
Obesity Reviews, 2011 SummaryAnimal research has well established that a link exists between variations in corticosteroids and the proneness to excess body fat accumulation. Accordingly, it is known that adrenalectomy is an efficient approach to counteract weight gain in most animal models of obesity.
L, Huneault, M-È, Mathieu, A, Tremblay
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Secular Trend in Age at Menarche and Associated Determinants in the Valencian Population (Spain)
American Journal of Human Biology, Volume 38, Issue 9, September 2026.The graphical abstract illustrates changes in age at menarche in the Valencian population (Spain) over nearly eight decades and its association with anthropometric and sociodemographic factors. ABSTRACT Objective To assess secular trend in age at menarche spanning nearly eight decades and to explore variations in these patterns according to selected ...
Andrea Beneito +11 more
wiley +1 more source
Environmental Obesogens: Mechanisms and Controversies [PDF]
Annual Review of Pharmacology and Toxicology, 2019 Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure.
Heindel, Jerrold J, Blumberg, Bruce
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