Results 61 to 70 of about 2,244 (165)

From rare familial mutations to multifactorial disease: aldo-keto reductase 1C enzymes as a central biological pathway in lipedema

Veins and Lymphatics
The discovery of pathogenic variants in AKR1C1 and AKR1C2 in ultra-rare familial lipedema highlights steroid hormone metabolism as a core mechanism affecting about 11% of women during reproductive age.
Daniil Vainberg, Jurgen Kaftalli, Luca Ferrari, Kristjana Dhuli, Beatrice Della Frera, Dominika Veselenyiova, Ahmad Jainul Abidin, Serena Michelni, Silvia Michelni, Sandro Michelni, Matteo Bertelli   +10 more
doaj   +1 more source

Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning

Obesity Reviews, Volume 25, Issue 10, October 2024.
Summary Our understanding of the pathophysiology of obesity remains at best incomplete despite a century of research. During this time, two alternative perspectives have helped shape thinking about the etiology of the disorder. The currently prevailing view holds that excessive fat accumulation results because energy intake exceeds energy expenditure ...
Mark I. Friedman, Thorkild I. A. Sørensen, Gary Taubes, Jens Lund, David S. Ludwig   +4 more
wiley   +1 more source

Environmental exposures: an underrecognized contribution to noncommunicable diseases [PDF]

, 2013
Previous attempts to determine the degree to which exposure to environmental factors contribute to noncommunicable diseases (NCDs) have been very conservative and have significantly underestimated the actual contribution of the environment for at least ...
Brune, Marie Noel, Carpenter, David O., Norman, Rosana E., Scott, James, Sly, Peter D.   +4 more
core   +3 more sources

Metabolic disrupting chemicals in the intestine: the need for biologically relevant models

FEBS Open Bio, Volume 14, Issue 9, Page 1397-1419, September 2024.
In this review, we aimed to study how the intestine may be disrupted by metabolic endocrine disruptors (MDCs) both in its own metabolism and in its relationships with other organs. Zebrafish shares numerous similarities with human gastrointestinal tract, representing an opportunity to study the complex interactions of MDCs at the intestinal level and ...
Chedi Erradhouani, Sylvie Bortoli, Selim Aït‐Aïssa, Xavier Coumoul, François Brion   +4 more
wiley   +1 more source

Growing Up Toxic: Chemical Exposures and Increases in Developmental Disease [PDF]

, 2011
Explains how exposure to toxic chemicals can harm health and impair development, causing premature birth, learning disabilities, behavioral disorders, asthma and allergies, and/or other problems.
Elizabeth Hitchcock, Travis Madsen
core  

Gender and racial/ethnic differences in the associations of urinary phthalate metabolites with markers of diabetes risk: national health and nutrition examination survey 2001–2008 [PDF]

, 2014
Background: Phthalates are ubiquitous endocrine disrupting chemicals associated with diabetes. Although women and minorities are more likely to be exposed to phthalates, no prior studies have examined phthalate exposure and markers of diabetes risk ...
Huang, Tianyi, Isganaitis, Elvira, James-Todd, Tamarra, Saxena, Aditi R   +3 more
core   +1 more source

Associations between paediatric obesity, chemical mixtures and environmental factors, in a national cross‐sectional study of Canadian children

Pediatric Obesity, Volume 19, Issue 8, August 2024.
Summary Background Whilst single chemical exposures are suspected to be obesogenic, the combined role of chemical mixtures in paediatric obesity is not well understood. Objectives We aimed to evaluate the potential associations between chemical mixtures and obesity in a population‐based sample of Canadian children.
Rose Dugandzic, Natalia Konstantelos, Yamei Yu, Eric Lavigne, Sebastian Srugo, Justin J. Lang, Kristian Larsen, Tyler Pollock, Paul Villeneuve, Errol M. Thomson, Miranda MacPherson, Robert Dales, Sabit Cakmak   +12 more
wiley   +1 more source

The interplay of post-translational modification and gene therapy [PDF]

, 2016
Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on ...
Azuh, Dominic E., Chinedu, S. N., Iweala, E. E. J., Ogunlana, Olubanke Olujoke, Osamor, V. C.   +4 more
core   +2 more sources

Effect of bariatric surgery in the body burden of persistent and non-persistent pollutants: longitudinal study in a cohort of morbidly obese patients

Frontiers in Endocrinology
IntroductionObesity is a pathological state that involves the dysregulation of different metabolic pathways and adipose tissue cells, constituting a risk factor for the development of other diseases. Bariatric surgery is the most effective treatment. The
B. Vanessa Díaz-González, B. Vanessa Díaz-González, Álvaro Ramos-Luzardo, Luis Alberto Henríquez-Hernández, Luis Alberto Henríquez-Hernández, Luis Alberto Henríquez-Hernández, Lluis Serra-Majem, Lluis Serra-Majem, Lluis Serra-Majem, Inmaculada Bautista-Castaño, Inmaculada Bautista-Castaño, Andrea Acosta-Dacal, Andrea Acosta-Dacal, Octavio P. Luzardo, Octavio P. Luzardo, Octavio P. Luzardo, Elisabeth Hernández-García, Judith Cornejo-Torre, Juan Ramón Hernández-Hernández, Juan Ramón Hernández-Hernández, Pilar Fernández-Valerón   +20 more
doaj   +1 more source

Obesogens: molecular signaling pathways in fish

Frontiers in Marine Science, 2015
* santos@ciimar.up.pt; filipe.castro@ciimar.up.pt In mammals, improper control of lipid metabolism may result in serious health problems such as obesity, increased risk of coronary disease, diabetes and related problems.
Miguel Machado Santos, Mónica Marques, Luis Filipe, C Castro   +2 more
doaj   +1 more source