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Journal of Separation Science, 2021
AbstractA rapid, robust, simple, selective, and sensitive liquid chromatography‐tandem mass spectrometry method was developed for the simultaneous estimation of obeticholic acid and its two pharmacologically active metabolites, glyco‐obeticholic acid, and tauro‐obeticholic acid in human plasma.
Naresh Kumar Katari +2 more
exaly +3 more sources
AbstractA rapid, robust, simple, selective, and sensitive liquid chromatography‐tandem mass spectrometry method was developed for the simultaneous estimation of obeticholic acid and its two pharmacologically active metabolites, glyco‐obeticholic acid, and tauro‐obeticholic acid in human plasma.
Naresh Kumar Katari +2 more
exaly +3 more sources
Obeticholic acid for the treatment of nonalcoholic steatohepatitis
Expert Review of Gastroenterology and Hepatology, 2020NAFLD has grown to become the most prevalent liver disease in the world, with a quarter of the general population estimated to have the disease. NASH, characterized as NAFLD with inflammation, is associated with worsening fibrosis along with increased incidence of HCC.
Kris V Kowdley
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A facile synthesis of ursodeoxycholic acid and obeticholic acid from cholic acid
Steroids, 2018A novel synthetic route of producing ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) was developed through multiple reactions from cheap and readily-available cholic acid. The reaction conditions of the key elimination reaction of mesylate ester group were also investigated and optimized, including solvent, base and reaction temperature.
Wen-Wei Qiu
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Obeticholic acid for the treatment of primary biliary cholangitis
Expert Opinion on Pharmacotherapy, 2016Primary biliary cholangitis (PBC) is an autoimmune disease of the liver characterized by destruction and inflammation of the intrahepatic bile ducts. The disease affects mainly women. The disease is often discovered through abnormal alkaline phosphatase (ALP) activity, and is confirmed when anti-mitochondrial antibodies (AMA) are present.
Ahmad H Ali, Keith D Lindor
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Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus)
Environmental Science and Pollution Research, 2019Analysis of brown bullhead (Ameiurus nebulosus) bile by ultra performance liquid chromatography high-resolution mass spectrometry (UPLC/HRMS) revealed a series of bile acids similar to those found in humans. Accordingly, we chose this fish as a model organism to examine the metabolism of obeticholic acid, a bile acid used to treat a number of human ...
Samuel Mach, Zdenek Šimek
exaly +3 more sources
Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers
Diabetes, Obesity and Metabolism, 2016The bile acid analogue obeticholic acid ( OCA ) is a selective farnesoid X receptor ( FXR ) agonist in development for treatment of several chronic liver diseases.
R, Pencek +5 more
exaly +3 more sources