Results 141 to 150 of about 1,214 (179)
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Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds
Toxicology Letters, 2010Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as reactivation can be anticipated.
H, Thiermann +6 more
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Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats
Toxicology and Applied Pharmacology, 1991The pharmacokinetics and pharmacodynamics of the oxime obidoxime (Toxogonin, 50 mg/kg iv) were investigated in anesthetized normal rats and in sarin-poisoned (50 micrograms/kg iv) rats. The kinetics were described by a two-compartment open model. The elimination half-life ranged from 35 min in normal rats to 86 min in sarin-poisoned rats.
C M, Alioth-Streichenberg +2 more
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Obidoxime in acute organophosphate poisoning: 2 – PK/PD relationships
Clinical Toxicology, 2009The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity.We measured the activity of cholinesterase in plasma and AChE in red ...
Horst, Thiermann +5 more
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Pharmacokinetics of Obidoxime in Organophosphate Poisoning Associated with Renal Failure
Journal of Toxicology: Clinical Toxicology, 1993Obidoxime is an oxime used in several countries as an antidote in organophosphate intoxication. Its pharmacokinetics were studied in a 20 year-old female with severe and complicated methamidophos intoxication. Obidoxime elimination half life was 6.9 h, volume of distribution 0.845 L/kg, total body clearance 85.4 mL/min, and renal clearance 69 mL/min ...
Y, Bentur +4 more
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Spectrometric and Voltammetric Characterization of Obidoxime in Aqueous Solutions
Analytical Letters, 2018Obidoxime is a pharmacologically active compound used as an acetylcholinesterase reactivator. The scope of this study was to establish correlations between its acid–base and redox equilibria and it...
Iulia Gabriela David +3 more
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Pharmacokinetics and efficacies of obidoxime and atropine in paraoxon poisoning
Archives of Toxicology, 1988The efficacies (ED50) of obidoxime and atropine against paraoxon poisoning in mice were determined by administering the antidotes 5, 20, 40 and 60 min before administration of the organophosphate. With increasing time intervals t between the administration of the antidote and paraoxon, the dose of antidote (ED50), that reduced the lethality of 2 LD50 ...
K, Schoene +3 more
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Increase in sensitivity to obidoxime induced by fluostigmine in the rat
Toxicology and Applied Pharmacology, 1978Abstract The acute toxicity of obidoxime and its effects on neuromuscular transmission were studied in rats previously treated with atropine and fluostigmine. A single injection of atropine and fluostigmine (2 mg/kg sc) was given and then obidoxime was administered after 3, 24, 48, or 72 hr.
J, Faff, W, Bak
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Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime
Biochemical Pharmacology, 1986Acetylcholinesterase was purified from human caudate nucleus and skeletal muscle. The enzyme preparations were used to study aging and reactivation by HI-6 and obidoxime after inhibition by soman and its isomers. HI-6 was found to be the most potent reactivator.
G, Puu, E, Artursson, G, Bucht
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Muscle & Nerve, 1995
AbstractSix patients with organophosphorus compound intoxications developed an intermediate syndrome (weakness and fasciculations) and obidoxime was given on eight occasions. The efficacy of the acetylcholinesterase (AChE) reactivator was monitored electrophysiologically by neuromuscular transmission studies using single and repetitive nerve ...
R, Besser, L S, Weilemann, L, Gutmann
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AbstractSix patients with organophosphorus compound intoxications developed an intermediate syndrome (weakness and fasciculations) and obidoxime was given on eight occasions. The efficacy of the acetylcholinesterase (AChE) reactivator was monitored electrophysiologically by neuromuscular transmission studies using single and repetitive nerve ...
R, Besser, L S, Weilemann, L, Gutmann
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Acetylcholine and Cholinesterase in Submandibular Glands of Rats Given Armin and Obidoxime
Journal of Dental Research, 1978The effects of obidoxime, a pyridinium oxime, on the cholinesterase activity and acetylcholine content of the submandibular glands of rats poisoned with armin, an organophosphorus anticholinesterase agent, were studied. The results indicate that obidoxime-induced reactivation of phosphorylated cholinesterase can suppress completely the increase in the ...
Vasić, Bogoslav V. +2 more
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