Therapeutic Interventions in Organophosphate Poisoning: An Umbrella Review of Systematic Reviews. [PDF]
West J Emerg MedChauhan V +4 more
europepmc +1 more source
Hemoadsorption: a new tool in neurotoxic poisoning. [PDF]
Front NephrolHernandez-Vaquero J +3 more
europepmc +1 more source
Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases. [PDF]
BiomoleculesKolić D +6 more
europepmc +1 more source
Validity of different scoring systems in prediction of intensive care unit admission and mortality in acute organophosphate poisoning. [PDF]
Toxicol Res (Camb)Sobeeh FG, Eldayem YBA, Khalifa HK.
europepmc +1 more source
Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds
Toxicology Letters, 2010 Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as reactivation can be anticipated.
Florian Eyer +2 more
exaly +4 more sources
Obidoxime in acute organophosphate poisoning: 1 – clinical effectiveness
Clinical Toxicology, 2009 The effects of obidoxime in the treatment of organophosphate poisoning were assessed by comparing the clinical course with its effects on laboratory parameters relevant to poisoning. In this article we report clinical findings and activity of cholinesterase in plasma and acetylcholinesterase (AChE) in red blood cells.
Florian Eyer +2 more
exaly +4 more sources
Obidoxime in acute organophosphate poisoning: 2 – PK/PD relationships
Clinical Toxicology, 2009 The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity.We measured the activity of cholinesterase in plasma and AChE in red ...
Florian Eyer +2 more
exaly +4 more sources
Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections
Journal of Pharmaceutical and Biomedical Analysis, 1987 It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ...
Karljiković-Rajić, Katarina +2 more
exaly +6 more sources
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats
Toxicology and Applied Pharmacology, 1991 The pharmacokinetics and pharmacodynamics of the oxime obidoxime (Toxogonin, 50 mg/kg iv) were investigated in anesthetized normal rats and in sarin-poisoned (50 micrograms/kg iv) rats. The kinetics were described by a two-compartment open model. The elimination half-life ranged from 35 min in normal rats to 86 min in sarin-poisoned rats.
Alioth-Streichenberg CM +2 more
openaire +4 more sources
Acetylcholine and Cholinesterase in Submandibular Glands of Rats Given Armin and Obidoxime
Journal of Dental Research, 1978 The effects of obidoxime, a pyridinium oxime, on the cholinesterase activity and acetylcholine content of the submandibular glands of rats poisoned with armin, an organophosphorus anticholinesterase agent, were studied. The results indicate that obidoxime-induced reactivation of phosphorylated cholinesterase can suppress completely the increase in the ...
Vasić, Bogoslav V. +2 more
openaire +4 more sources