Results 141 to 150 of about 706 (177)
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Efficacy of Pralidoxime Iodide and Obidoxime Dichloride as Antidotes in Diazinon-Poisoned Goslings
Avian Diseases, 1976The antidotal efficacy of pralidoxime iodide and obidoxime dichloride was investigated in goslings poisoned by a supralethal dose of the organophosphorus insecticide diazinon. Various doses of both drugs were administered by intramuscular injection when the poisoned birds were unable to walk. Pralidoxime at 100 mg/kg brought about a complete and speedy
A, Shlosberg +4 more
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Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime
Biochemical Pharmacology, 1986Acetylcholinesterase was purified from human caudate nucleus and skeletal muscle. The enzyme preparations were used to study aging and reactivation by HI-6 and obidoxime after inhibition by soman and its isomers. HI-6 was found to be the most potent reactivator.
G, Puu, E, Artursson, G, Bucht
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Muscle & Nerve, 1995
AbstractSix patients with organophosphorus compound intoxications developed an intermediate syndrome (weakness and fasciculations) and obidoxime was given on eight occasions. The efficacy of the acetylcholinesterase (AChE) reactivator was monitored electrophysiologically by neuromuscular transmission studies using single and repetitive nerve ...
R, Besser, L S, Weilemann, L, Gutmann
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AbstractSix patients with organophosphorus compound intoxications developed an intermediate syndrome (weakness and fasciculations) and obidoxime was given on eight occasions. The efficacy of the acetylcholinesterase (AChE) reactivator was monitored electrophysiologically by neuromuscular transmission studies using single and repetitive nerve ...
R, Besser, L S, Weilemann, L, Gutmann
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Effect of Phosphamidon and Obidoxime on the QT‐RR Relationship of Isolated Rat Heart
Pharmacology & Toxicology, 1992Abstract: We studied the effects of phosphamidon (an organophosphate compound), obidoxime (a cholinesterase reactivator), and their combination, phosphamidon/obidoxime (PD/OB) on cardiac cycle length (RR), QT interval, and on QT‐RR relationship of isolated rat heart.
S A, Ben-Haim +4 more
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Journal of Pharmaceutical and Biomedical Analysis, 2009
A rapid selective and accurate quantitative (1)H NMR method was developed for the simultaneous analysis of obidoxime chloride and atropine sulfate, the active components in parenteral injection devices (PID) used for the emergency treatment of poisoning by toxic organophosphates.
Radha, Sharma +5 more
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A rapid selective and accurate quantitative (1)H NMR method was developed for the simultaneous analysis of obidoxime chloride and atropine sulfate, the active components in parenteral injection devices (PID) used for the emergency treatment of poisoning by toxic organophosphates.
Radha, Sharma +5 more
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Pharmacokinetics of [14C]-Sarin and Its Changes by Obidoxime and Pralidoxime
1986Sarin was invented by Schrader in 1937 (6). It was one of the first examples of an organophosphate; it was later stockpiled with other similar compounds (soman, tabun and VX) as nerve gases for warfare. Of all the other 2000 organophosphorus compounds synthesized as insecticides, only several have been used to a major extent in agriculture.
P. G. Waser +3 more
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Beneficial late administration of obidoxime in malathion poisoning.
Veterinary and human toxicology, 2003Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery. Data on efficacy of late administration of oximes, particularly obidoxime, is limited. A 42-y old woman swallowed 60 ml of 50% malathion in a suicide attempt. Characteristic muscarinic, nicotinic and central manifestations
Yedidia, Bentur +2 more
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Toxicology Mechanisms and Methods, 2010
Obidoxime, a well-known bis-pyridinium reactivator, is often the preferred antidote of organophosphorus poisoning caused by pesticides and tabun. It is also considered to be an allosteric modulator of muscarinic receptors, preferably M2 sub-type.
Ondrej, Soukup +5 more
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Obidoxime, a well-known bis-pyridinium reactivator, is often the preferred antidote of organophosphorus poisoning caused by pesticides and tabun. It is also considered to be an allosteric modulator of muscarinic receptors, preferably M2 sub-type.
Ondrej, Soukup +5 more
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Obidoxime Augments the Positive Inotropic Effect of Phosphamidon on the Isolated Working Rat Heart
Pharmacology & Toxicology, 1992Abstract: The present study was designed to determine modulation of the direct inotropic effect of an anticholinesterase organophosphorus compound, phosphamidon, by the reactivator obidoxime. We investigated the effects of phosphamidon (n = 9), obidoxime (n = 5), and their combination (n = 5) on the mechanical and energetic indices of left ventricular
S A, Ben-Haim +4 more
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Toxicology, 2016
Despite extensive research for decades no effective broad-spectrum oxime for the treatment of poisoning by a broad range of nerve agents is available. Previous in vitro and in vivo data indicate that the combination of in service oximes could be beneficial.
Franz, Worek +3 more
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Despite extensive research for decades no effective broad-spectrum oxime for the treatment of poisoning by a broad range of nerve agents is available. Previous in vitro and in vivo data indicate that the combination of in service oximes could be beneficial.
Franz, Worek +3 more
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