Results 131 to 140 of about 1,015 (193)

Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases. [PDF]

Biomolecules
Kolić D, Šinko G, Jean L, Chioua M, Dias J, Marco-Contelles J, Kovarik Z.   +6 more
europepmc   +1 more source

Validity of different scoring systems in prediction of intensive care unit admission and mortality in acute organophosphate poisoning. [PDF]

Toxicol Res (Camb)
Sobeeh FG, Eldayem YBA, Khalifa HK.
europepmc   +1 more source

Fetuin-A is a predictor of mortality in organophosphate poisoning. [PDF]

Medicine (Baltimore)
Ozbay S, Coskun A, Ozsoy O, Ozsoy O, Kavalci G, Kavalci C.   +5 more
europepmc   +1 more source

Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates. [PDF]

J Xenobiot
Shriwas P, Noonchester AM, Revnew A, Lane TR, Hadad CM, Ekins S, McElroy CA.   +6 more
europepmc   +1 more source

Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy. [PDF]

PLoS One
Turner SR, Timperley CM, Bird M, Green AC, Price ME, Rice H, Chad JE, Tattersall JEH.   +7 more
europepmc   +1 more source

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Obidoxime in acute organophosphate poisoning: 1 – clinical effectiveness

Clinical Toxicology, 2009
The effects of obidoxime in the treatment of organophosphate poisoning were assessed by comparing the clinical course with its effects on laboratory parameters relevant to poisoning. In this article we report clinical findings and activity of cholinesterase in plasma and acetylcholinesterase (AChE) in red blood cells.
Florian Eyer, Franz Worek, Horst Thiermann   +2 more
exaly   +3 more sources

Obidoxime in acute organophosphate poisoning: 2 – PK/PD relationships

Clinical Toxicology, 2009
The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity.We measured the activity of cholinesterase in plasma and AChE in red ...
Horst Thiermann, Franz Worek, Florian Eyer   +2 more
exaly   +3 more sources

Interaction of obidoxime with sarin in aqueous solution

Archives of Toxicology, 1992
The interaction of obidoxime (Toxogonin) with sarin was shown by different analytical methods. The UV spectrum of obidoxime at pH 7.4 yields two absorption maxima, lambda 1 = 284 nm and lambda 2 = 353 nm. The peak at lambda 2 = 353 nm is representative for the amount of zwitter-ionic obidoxime, i.e. the active form of obidoxime.
P G, Waser, C M, Alioth-Streichenberg, W H, Hopff, R, Portmann, W, Hofmann, A, Niederhauser   +5 more
openaire   +2 more sources

Administration of obidoxime tablets to man

Archives of Toxicology, 1976
Twenty-four male volunteers were given obidoxime tablets in quantities ranging from 1.84-3.58 g in a single dose, or 7.36 g divided into 4 equal doses. With the lowest dose, average peak plasma level of the drug was 1.9 mug/ml and after the highest single dose it was 5.6 mug/ml, both attained 1.5 h after administration.
G A, Simon, M S, Tirosh, H, Edery
openaire   +2 more sources

Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats

Toxicology and Applied Pharmacology, 1991
The pharmacokinetics and pharmacodynamics of the oxime obidoxime (Toxogonin, 50 mg/kg iv) were investigated in anesthetized normal rats and in sarin-poisoned (50 micrograms/kg iv) rats. The kinetics were described by a two-compartment open model. The elimination half-life ranged from 35 min in normal rats to 86 min in sarin-poisoned rats.
C M, Alioth-Streichenberg, D M, Bodmer, P G, Waser   +2 more
openaire   +2 more sources