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Interaction of obidoxime with sarin in aqueous solution
Archives of Toxicology, 1992The interaction of obidoxime (Toxogonin) with sarin was shown by different analytical methods. The UV spectrum of obidoxime at pH 7.4 yields two absorption maxima, lambda 1 = 284 nm and lambda 2 = 353 nm. The peak at lambda 2 = 353 nm is representative for the amount of zwitter-ionic obidoxime, i.e. the active form of obidoxime.
P G Waser
exaly +3 more sources
Pharmacokinetics of Obidoxime in Organophosphate Poisoning Associated with Renal Failure
Journal of Toxicology: Clinical Toxicology, 1993Obidoxime is an oxime used in several countries as an antidote in organophosphate intoxication. Its pharmacokinetics were studied in a 20 year-old female with severe and complicated methamidophos intoxication. Obidoxime elimination half life was 6.9 h, volume of distribution 0.845 L/kg, total body clearance 85.4 mL/min, and renal clearance 69 mL/min ...
Y, Bentur +4 more
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Biochemical Pharmacology, 1971
Abstract The reactivator obidoxime given twice i.p. at a dose of 12.5 mg/kg shortly before and after DFP (1.5 mg/kg s.c.), or given only once at a dose of 25 mg/kg shortly after DFP, prevented the rise of rat brain acetylcholine (ACh) observed 90 min after the anticholinesterase (antiChE) agent.
O, Mayer, H, Michalek
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Abstract The reactivator obidoxime given twice i.p. at a dose of 12.5 mg/kg shortly before and after DFP (1.5 mg/kg s.c.), or given only once at a dose of 25 mg/kg shortly after DFP, prevented the rise of rat brain acetylcholine (ACh) observed 90 min after the anticholinesterase (antiChE) agent.
O, Mayer, H, Michalek
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Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions
Pflugers Archiv European Journal of Physiology, 1984The effect of the oxime reactivator obidoxime chloride (obidoxime) on single frog neuromuscular junctions has been studied in order to clarify its action on the acetylcholine receptor (AChR) and on the acetylcholine esterase (AChE), both before and after blocking its enzymatic activity with the organophosphorus compound sarin. Experiments iontophoretic
C G Caratsch, P G Waser
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Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats
Toxicology, 1995The action of HI-6 (1-[[[(4-aminocarbonyl)pyridiniol]methoxy]methyl]-2-[ (hydroxyimino)methyl] pyridinium dichloride monohydrate) and obidoxime on soman-induced anticholinesterase and stressogenic effects was studied in rats. HI-6 significantly affected acetylcholinesterase inhibition in erythrocytes, brain and diaphragm and practically eliminated the ...
Jiří Kassa
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, 2007 Increase in sensitivity to obidoxime induced by fluostigmine in the rat
Toxicology and Applied Pharmacology, 1978Abstract The acute toxicity of obidoxime and its effects on neuromuscular transmission were studied in rats previously treated with atropine and fluostigmine. A single injection of atropine and fluostigmine (2 mg/kg sc) was given and then obidoxime was administered after 3, 24, 48, or 72 hr.
J, Faff, W, Bak
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Administration of obidoxime tablets to man
Archives of Toxicology, 1976Twenty-four male volunteers were given obidoxime tablets in quantities ranging from 1.84-3.58 g in a single dose, or 7.36 g divided into 4 equal doses. With the lowest dose, average peak plasma level of the drug was 1.9 mug/ml and after the highest single dose it was 5.6 mug/ml, both attained 1.5 h after administration.
G A, Simon, M S, Tirosh, H, Edery
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Pharmacokinetics and efficacies of obidoxime and atropine in paraoxon poisoning
Archives of Toxicology, 1988The efficacies (ED50) of obidoxime and atropine against paraoxon poisoning in mice were determined by administering the antidotes 5, 20, 40 and 60 min before administration of the organophosphate. With increasing time intervals t between the administration of the antidote and paraoxon, the dose of antidote (ED50), that reduced the lethality of 2 LD50 ...
K, Schoene +3 more
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Spectrometric and Voltammetric Characterization of Obidoxime in Aqueous Solutions
Analytical Letters, 2018Obidoxime is a pharmacologically active compound used as an acetylcholinesterase reactivator. The scope of this study was to establish correlations between its acid–base and redox equilibria and it...
Iulia Gabriela David +3 more
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