Dermatology Online Journal, 2008 A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use. A limited number of similar reports exist in the US literature and are the basis for an FDA call to review hydroquinone-based products.
Merola, Joseph F +3 more
openaire +4 more sources
Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment. [PDF]
, 2016 BACKGROUND: Alkaptonuria (AKU) is a serious genetic disease characterised by premature spondyloarthropathy. Homogentisate-lowering therapy is being investigated for AKU.
Andrea Zatkova +51 more
core +1 more source
Ochronosis as an unusual cause of valvular defect: a case report
Journal of Medical Case Reports, 2009 Introduction Alkaptonuria (also known as ochronosis) is a genetic disorder characterised by the accumulation of homogentisic acid deposits in connective tissue. In rare cases, ochronosis can cause valvular heart disease.
Steverding Dietmar, Wilke Andreas
doaj +1 more source
What does the arthropathy of alkaptonuria teach us about disease mechanisms in osteoarthritis and ageing of joints? Lessons from a rare disease [PDF]
, 2016 AKU Society, the Rosetrees Foundation, the Childwick Trust, the Big Lottery and ...
Alan Boyde +4 more
core +1 more source
Journal of the American Academy of Dermatology, 2000 Ochronosis is an uncommon condition characterized by yellow-brown pigment deposits in the dermis. It occurs in exogenous and endogenous forms. We report a case of exogenous ochronosis in a Hispanic woman and discuss the different forms of this condition. We treated the lesions with Q-switched ruby laser.
K E, Kramer +3 more
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Exogenous ochronosis superimposed on chronic kidney disease: A case report and review of literature
Sahel Medical Journal, 2018 Ochronosis is a rare disease characterized by speckled and diffuse pigmentation symmetrically over the face, neck, and photo-exposed areas. It can present in exogenous or endogenous form.
Ishrat Hussain Dar +4 more
doaj +1 more source
Ochronotic Chondropathy: A Case Report
Biomedicines, 2023 Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman +4 more
doaj +1 more source
Endogenous ochronosis with keratoelastoidosis marginalis
Indian Journal of Dermatopathology and Diagnostic Dermatology, 2019 Endogenous ochronosis is a manifestation of alkaptonuria, a rare metabolic disease due to homogentisic acid oxidase deficiency. Darkened urine and arthropathy are the other two components that complete the triad of alkaptonuria. Pigmentation of skin, the
R Mythreyi +4 more
doaj +1 more source
Knowledge, Perceptions, and Practices of Skin-Lightening Products Among Female Medical Students: A Cross-Sectional Study. [PDF]
J Cosmet DermatolABSTRACT Objective The use of skin‐lightening products (SLPs) is a widespread phenomenon influenced by cultural, social, and aesthetic perceptions. However, the awareness of their potential dermatological and systemic risks remains inadequate, particularly among young women, including medical students.
Qeyam H +3 more
europepmc +2 more sources
Phytochemical Composition of Selaginella spp. from Java Island Indonesia [PDF]
, 2012 For a long time, people in West Java, Indonesia have used Selaginella as a traditional cure for several ailments including fever, minor wounds, broken bones, women’s health disorders or postnatal bleeding.
Chikmawati, Tatik +2 more
core +3 more sources