Results 181 to 190 of about 6,916 (201)

Association between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome

International Journal of Molecular Sciences, 2019
Insulin-sensitizer treatment with metformin is widely used in polycystic ovary syndrome (PCOS). However, the treatment effectiveness shows individual differences in PCOS patients.
Hui Chang, Yuan-Shuo Hsueh, Huang-Tz Ou   +2 more
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288 OCT1 AS A PROGNOSTIC FACTOR FOR PROSTATE CANCER

Journal of Urology, 2011
INTRODUCTION AND OBJECTIVES: Androgen receptor (AR) plays a role in prostate cancer development and progression. Alteration of AR coregulators expression leads to hypersensitivity of AR, which is supposed to be one of the mechanisms for prostate cancer progression to castrate -resistant state.
Daisuke Obinata, Ken-ichi Takayama, Tomohiko Urano, Taro Murata, Jinpei Kumagai, Tetsuya Fujimura, Kazuhiro Ikeda, Kuniko Horie-Inoue, Satoru Takahashi, Satoshi Inoue   +9 more
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Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2

Nature Structural & Molecular Biology, 2023
A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition. In mammals, organic cation transporter (OCT) subtypes 1 and 2 (OCT1 and OCT2, also known as SLC22A1 and SLC22A2, respectively) are polyspecific transporters responsible for the uptake and clearance of ...
Yang Suo, Nicholas J. Wright, Hugo Guterres, Justin G. Fedor, Kevin John Butay, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee   +7 more
openaire   +2 more sources

Purification and Functional Reconstitution of the Rat Organic Cation Transporter OCT1

Biochemistry, 2005
The rat organic cation transporter rOCT1 with six histidine residues added to the C-terminus was expressed in Sf9 insect cells, and expression of organic cation transport was demonstrated. To purify rOCT1 protein, Sf9 cells were lysed with 1% (w/v) CHAPS [3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate], centrifuged, and subjected to ...
Thorsten, Keller, Marco, Elfeber, Valentin, Gorboulev, Helmut, Reiländer, Hermann, Koepsell   +4 more
openaire   +2 more sources

Localization of organic cation transporters OCT1 and OCT2 in rat kidney

American Journal of Physiology-Renal Physiology, 2000
Renal excretion and reabsorption of organic cations are mediated by electrogenic and electroneutral organic cation transporters, which belong to a recently discovered family of polyspecific transporters. These transporters are electrogenic and exhibit differences in substrate specificity.
U, Karbach, J, Kricke, F, Meyer-Wentrup, V, Gorboulev, C, Volk, D, Loffing-Cueni, B, Kaissling, S, Bachmann, H, Koepsell   +8 more
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OCT1 and imatinib transport in CML: is it clinically relevant?

Leukemia, 2015
Imatinib is a highly effective therapy for chronic phase-chronic myeloid leukaemia (CP-CML) patients; however, responses to frontline imatinib are variable. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in imatinib uptake into CML cells.
D B, Watkins, T P, Hughes, D L, White
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Oct1 and Oca-B Regulate the Myeloid Leukemic Phenotype

Blood, 2016
Abstract Oct1, encoded by the Pou2f1 gene, is a widely expressed transcription factor that is associated with metabolic control, stress response, stem cell phenotypes and malignant transformation. Oct1 associates with a number of cofactors including the activating cofactor OCA-B encoded by Pou2af1.
Jillian Jafek, Arvind Shakya, Pei-Yi Tai, Gerald J Spangrude, Todd W Kelley, Dean Tantin   +5 more
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Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response

Pharmacogenetics and Genomics, 2010
Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene, coding for MATE1, are associated with the degree of glucose ...
Becker, Matthijs, Visser, Loes, van Schaik, Ron, Hofman, Bert, Uitterlinden, André, Stricker, Bruno   +5 more
openaire   +3 more sources

In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1

International Journal of Pharmaceutics, 2014
Clopidogrel (CP) is metabolized by CYPs to the active metabolite, or hydrolyzed by esterase to clopidogrel carboxylate (CPC) in liver, and CPC is partly excreted from urine. Therefore, the objective of the present study was to evaluate the interactions of CP and CPC with organic cation transporter 1 (OCT1) (in liver), and CPC with organic cation ...
Liping, Li, Feifeng, Song, Meijuan, Tu, Kai, Wang, Lei, Zhao, Xiaodan, Wu, Hui, Zhou, Zongling, Xia, Huidi, Jiang   +8 more
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Interaction between zebrafish Oct1 and endo- and xenobiotics

Aquatic toxicology, 2017
Playing as key elements in absorption, distribution, metabolism and excretion (ADME) processes of numerous endo- and xenobiotics, human organic cation transporters (OCTs) have been in focus of the toxicological research for more than a decade. These membrane transporters belong to SLC22A family within the SLC (Solute carrier) protein superfamily and in
Mihaljević, Ivan, Popović, Marta, Žaja, Roko, Maraković, Nikola, Šinko, Goran, Smital, Tvrtko   +5 more
openaire   +3 more sources