Results 81 to 90 of about 147,099 (176)

Harnessing miR-145 in NSCLC: mechanistic roles, diagnostic-prognostic utility, and therapeutic potential

Cancer Cell International
Non-small cell lung cancer (NSCLC) is responsible for most lung cancer diagnoses and causes elevated worldwide mortality rates, mostly due to late detection and the development of resistance against medicines.
Safa Tahmasebi, Davar Amani, Ian M. Adcock, Esmaeil Mortaz   +3 more
doaj   +1 more source

Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley   +1 more source

A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma

Cell Communication and Signaling
Background Increasing evidence has indicated that long non-coding RNAs (lncRNAs) have been proven to regulate esophageal cancer progression. The lncRNA protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) has been shown to promote cancer ...
Tao Huang, Qi You, Dengjun Huang, Yan Zhang, Zhijie He, Xuguang Shen, Fei Li, Qiang Shen, Ifeanyi Christian Onyebuchi, Chengwei Wu, Feng Liu, Shaojin Zhu   +11 more
doaj   +1 more source

Biocompatible Gold Nanoparticles Ameliorate Retinoic Acid-Induced Cell Death and Induce Differentiation in F9 Teratocarcinoma Stem Cells

Nanomaterials, 2018
The unique properties of gold nanoparticles (AuNPs) have attracted much interest for a range of applications, including biomedical applications in the cosmetic industry. The current study assessed the anti-oxidative effect of AuNPs against retinoic acid (
Sangiliyandi Gurunathan, Jin-Hoi Kim
doaj   +1 more source

Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis

The Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY In plants, nucleotide de novo synthesis is required throughout development to provide building blocks for the synthesis of DNA, RNA and nucleotide‐derived cofactors. Inosine Monophosphate Dehydrogenases (IMPDH) are key enzymes in de novo guanylate synthesis.
Eva Dörfer, Zahra Sadeghi, Vincent Frick, Katharina Ebel, Adrian Heide, Tom Niehoff, Susanne Zehner, Lisa Fischer, Claus‐Peter Witte, Marco Herde, Torsten Möhlmann   +10 more
wiley   +1 more source

CircMETTL6 Suppresses Ovarian Cancer Cell Growth and Metastasis Through Inhibition of GDF15 Transcription by Disrupting the NONO‐POLR2A Complex

Advanced Science
Circular RNAs (circRNAs) are a distinctive class of non‐coding RNAs with covalent closed‐loop structure, lacking 5′ caps and 3′ poly(A) tails. These molecules are prevalent in eukaryotes and play key roles in cancer.
Mengqian Yu, Mengting Wu, Tao Shen, Qiongzi Qiu, Aoran Luo, Jia Li, Xufan Li, Xiaodong Cheng, Bingjian Lu, Weiguo Lu, Pengyuan Liu, Yan Lu   +11 more
doaj   +1 more source

In vitro Characteristics of Heterogeneous Equine Hoof Progenitor Cell Isolates

Frontiers in Bioengineering and Biotechnology, 2019
Damage to an ectodermal-mesodermal interface like that in the equine hoof and human finger nail bed can permanently alter tissue structure and associated function.
Qingqiu Yang, Vanessa Marigo Rocha Pinto, Wei Duan, Erica E. Paxton, Jenna H. Dessauer, William Ryan, Mandi J. Lopez   +6 more
doaj   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

Journal of Experimental & Clinical Cancer Research, 2019
Background The inflammatory cytokine interleukin-6 (IL-6) is critical for the expression of octamer-binding transcription factor 4 (OCT4), which is highly associated with early tumor recurrence and poor prognosis of hepatocellular carcinomas (HCC).
Ssu-Chuan Lai, Yu-Ting Su, Ching-Chi Chi, Yung-Che Kuo, Kam-Fai Lee, Yu-Chih Wu, Pei-Chi Lan, Muh-Hwa Yang, Te-Sheng Chang, Yen-Hua Huang   +9 more
doaj   +1 more source

Blockade of Src signaling prevented stemness gene expression and proliferation of patient-derived gastric cancer stem cells

Tzu Chi Medical Journal
Objectives: Gastric cancer (GC) is one of the most malignant tumors. Mounting studies highlighted gastric cancer stem cells (GCSCs) were responsible for the failure of treatment due to recurrence and drug resistance of advanced GC.
Chi-Tan Hu, Chen-Fang Lin, Hsiu-Ming Shih, Ren-In You, Wen-Sheng Wu, Yen-Cheng Chen   +5 more
doaj   +1 more source