Results 21 to 30 of about 25,891 (205)

Meta-analysis on the effects of octreotide on tumor mass in acromegaly. [PDF]

PLoS ONE, 2012
BACKGROUND: The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower growth hormone (GH) levels in patients with acromegaly and may also induce pituitary tumor shrinkage.
Andrea Giustina, Gherardo Mazziotti, Valter Torri, Maurizio Spinello, Irene Floriani, Shlomo Melmed   +5 more
doaj   +1 more source

Efficacy and safety of octreotide treatment for diazoxide‐unresponsive congenital hyperinsulinism in China

Pediatric Investigation, 2020
Importance Octreotide is an off‐label medicine for congenital hyperinsulinism (CHI), but is currently widely used for treatment of patients with CHI. Thus far, variable efficacy and adverse effects have been reported for octreotide. Objective The present
Bingyan Cao, Wu Di, Chang Su, Jiajia Chen, Xuejun Liang, Min Liu, Wenjing Li, Xiaoqiao Li, Chunxiu Gong   +8 more
doaj   +1 more source

Somatostatin Octapeptide Inhibits Cell Invasion and Metastasis in Hepatocellular Carcinoma Through PEBP1

Cellular Physiology and Biochemistry, 2018
Background/Aims: Hepatocellular carcinoma (HCC) is a major threat to human health. The condition carries a high risk of death; 45% of new cases occur in China.
Chuan-Zhong Huang, Ai-Min Huang, Jing-Feng Liu, Bin Wang, Ke-Can Lin, Yun-Bin Ye   +5 more
doaj   +1 more source

Octreotide acetate enhanced radio sensitivity and induced apoptosis in MCF7 breast cancer cell line

Journal of Radiation Research and Applied Sciences, 2022
Introduction: Breast cancer is the most common type of cancer among women. Radiotherapy is one of the treatment options for breast cancer; it plays a significant role in tumour control after surgery. However, radio resistance developed by tumour cells is
Alkhansa Salih Mahmoud, Md Zuki Abu Bakar, Hazilawati Hamzah, Tengku Ahbrizal Tengkue Ahmad, Mohd Hezmee Mohd Noor   +4 more
doaj   +1 more source

Octreotide Use in a Patient with MEN-1 Syndrome and Multifocal Pancreatic Neuroendocrine Tumors: A Case Report and Review of the Literature

Case Reports in Gastrointestinal Medicine, 2019
We report a patient with multiple endocrine neoplasia type 1 with pancreatic polypeptide (PP) secreting subcentimeter pancreatic neuroendocrine tumors (pNETs) treated with octreotide and review the current literature that pertains to the management of ...
Matthew H. Kemm, Cory D. Manly, Thanh D. Hoang, Vinh Q. Mai, Mohamed K. M. Shakir   +4 more
doaj   +1 more source

Octreotide-induced thrombocytopenia: a case report

Journal of Medical Case Reports, 2011
Introduction Thrombocytopenia is an extremely rare complication of octreotide therapy and can be life threatening in the setting of esophageal variceal bleeding.
Rizvi Nahid, Rashidi Armin
doaj   +1 more source

Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: A pilot study

Laryngoscope Investigative Otolaryngology, 2023
Background Pharyngocutaneous fistula (PCF) and salivary leaks are well known complications of head and neck surgery. The medical management of PCF has included the use of octreotide without a well‐defined understanding of its therapeutic mechanism.
Jonathan Cohen, William Reed, Matthew W. Foster, Russel R. Kahmke, Daniel J. Rocke, Liana Puscas, Trinitia Y. Cannon, Walter T. Lee   +7 more
doaj   +1 more source

Development of a method for preparing octreotide derivative for diagnosis of neuroendocrine tumors

Бюллетень сибирской медицины, 2019
Currently the development of technologies for labeling somatostatin with technetium-99m for diagnosing radionuclide neuroendocrine tumors is under way. Somatostatin analogues are binded with technetium99m only by the preliminary addition of a chelating ...
M. S. Larkina, E. V. Podrezova, O. D. Bragina, E. A. Tagirova, V. I. Chernov, M. S. Yusubov, E. A. Nesterov, V. S. Skuridin, S. V. Krivoshchekov, E. A. Yanovskaya, R. V. Gurto, M. V. Belousov   +11 more
doaj   +1 more source

Automated GMP compliant production of [18F]AlF-NOTA-octreotide

EJNMMI Radiopharmacy and Chemistry, 2020
Background Gallium-68 labeled synthetic somatostatin analogs for PET/CT imaging are the current gold standard for somatostatin receptor imaging in neuroendocrine tumor patients.
Térence Tshibangu, Christopher Cawthorne, Kim Serdons, Elin Pauwels, Willy Gsell, Guy Bormans, Christophe M. Deroose, Frederik Cleeren   +7 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source