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Drug delivery from ocular implants
Expert Opinion on Drug Delivery, 2006Developing an intraocular drug delivery system (DDS) is urgently needed because most vitreoretinal diseases are refractory to conventional pharmacological approaches; eye drops and systemically administered drugs cannot deliver therapeutic drug concentrations into vitreoretinal tissue. Intraocular DDSs address this problem.
Tsutomu, Yasukawa +4 more
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Nanotechnology in ocular drug delivery
Drug Discovery Today, 2008Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomical and
Sanjeeb K, Sahoo +2 more
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Recent advances in ocular drug delivery
Drug Development and Industrial Pharmacy, 2012Amongst the various routes of drug delivery, the field of ocular drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. Recent research has focused on the characteristic advantages and limitations of the various drug delivery systems, and further research will be required before the ideal system can ...
Djamila, Achouri +3 more
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Ocular drug delivery conventional ocular formulations
Advanced Drug Delivery Reviews, 1995Abstract Within the last few decades, in response to the advent of potent and versatile therapeutic agents, the diversity of conventional ophthalmic formulations has gradually evolved, extending well beyond simple solutions, and now includes a variety of types of drug administration.
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Redefining ocular drug delivery
The Ocular Surface, 2022Allisa J. Song +2 more
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Ocular drug delivery in veterinary medicine
Advanced Drug Delivery Reviews, 1997This paper provides a comprehensive overview of the various approaches currently used in the development of ocular drug delivery systems for the treatment of ocular diseases in animals. It is obvious from the literature that most of the products that are currently available are derived from human medicine without consideration given to the differences ...
Baeyens, Vincent +5 more
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Bioerodible Polymers for Ocular Drug Delivery
Critical Reviews in Therapeutic Drug Carrier Systems, 1998Development of ophthalmic drug-delivery systems has always been challenging. The commonly used route for drug delivery to the anterior segment of the eye has been the conjunctival cul-de-sac. Because of drawbacks associated with this route, new approaches have been investigated for delivery of drugs to the eye by means of polymeric delivery systems ...
Deshpande, Arati +2 more
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Designing dendrimers for ocular drug delivery
European Journal of Medicinal Chemistry, 2010New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used
Grégory, Spataro +7 more
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Ophthalmologists and drug delivery scientists face considerable challenges in the realm of ocular drug delivery, primarily attributable to the intricate structural and barrier complexities inherent in the eye. The presence of various barriers, including the multilayered cornea, sclera, conjunctival blood flow, and tear dilution, imposes limitations on ...
Harshilkumar S. Jani +3 more
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Harshilkumar S. Jani +3 more
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