Results 1 to 10 of about 326,657 (100)

Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride [PDF]

Nanomedicine Journal, 2015
Objective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in ...
Sahar Mohamaddoust Aliabadi, Farnaz Sadat Mirzazadeh Tekie, Omid Rajabi, Mohammad Reza Abbaspour, Elham Khodaverdi   +4 more
doaj   +1 more source

Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma

Molecules, 2022
Human malignant melanoma exhibits imbalances in redox status, leading to activation of many redox-sensitive signaling pathways. APE/Ref-1 is a multifunctional protein that serves as a redox chaperone that regulates many nuclear transcription factors and ...
Razan Alhazmi, Shirley Tong, Shaban Darwish, Elina Khanjani, Bharti Khungar, Swati Chawla, Zhonghui Zheng, Richard Chamberlin, Keykavous Parang, Sun Yang   +9 more
doaj   +1 more source

The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both contribute to cirrhosis.
Lin-Yan Wan, Hu Peng, Yi-Ran Ni, Xue-Ping Jiang, Jiao-Jiao Wang, Yan-Qiong Zhang, Lan Ma, Rui Li, Lin Han, Yong Tan, Jun-Ming Li, Wen-Li Cai, Wen-Fang Yuan, Jia-Jie Liang, Lu Huang, Xu Wu, Quan Zhou, Qi-Ni Cheng, Xue Yang, Meng-Yuan Liu, Wen-Bing Ai, Chang-Bai Liu, Hongbing Zhang, Jiang-Feng Wu   +23 more
doaj   +1 more source

Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents

Pharmaceuticals, 2023
The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins.
Jonathan Moreno, Khalid Zoghebi, David Salehi, Lois Kim, Sorour Khayyatnejad Shoushtari, Rakesh K. Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

Advanced NanoBiomed Research, 2022
Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell.
Maria Poley, Gal Chen, Noga Sharf-Pauker, Aviram Avital, Maya Kaduri, Mor Sela, Patricia Mora Raimundo, Lilach Koren, Sivan Arber, Egor Egorov, Janna Shainsky, Jeny Shklover, Avi Schroeder   +12 more
doaj   +1 more source

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents

Cells, 2022
A series of cyclic peptides, [(DipR)(WR)4], [(DipR)2(WR)3], [(DipR)3(WR)2], [(DipR)4(WR)], and [DipR]5, and their linear counterparts containing arginine (R) as positively charged residues and tryptophan (W) or diphenylalanine (Dip) as hydrophobic ...
David Salehi, Saghar Mozaffari, Khalid Zoghebi, Sandeep Lohan, Dindyal Mandal, Rakesh K. Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery

Pharmaceutics, 2022
Recent approvals of siRNA-based products motivated the scientific community to explore siRNA as a treatment option for several intractable ailments, especially cancer.
Muhammad Imran Sajid, Dindyal Mandal, Naglaa Salem El-Sayed, Sandeep Lohan, Jonathan Moreno, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines

Pharmaceutics, 2023
RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging.
Dindyal Mandal, Sandeep Lohan, Muhammad Imran Sajid, Abdulelah Alhazza, Rakesh Kumar Tiwari, Keykavous Parang, Hamidreza Montazeri Aliabadi   +6 more
doaj   +1 more source

[(WR)₈WKβA]-Doxorubicin Conjugate: A Delivery System to Overcome Multi-Drug Resistance against Doxorubicin

Cells, 2022
Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired resistance are major drawbacks, limiting its clinical application.
Khalid Zoghebi, Hamidreza Montazeri Aliabadi, Rakesh Kumar Tiwari, Keykavous Parang   +3 more
doaj   +1 more source

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds

Molecules, 2023
The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore ...
Shilpi Gupta, Shang Eun Park, Saghar Mozaffari, Bishoy El-Aarag, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source