Preparation and evaluation of electrospun nanofibers containing pectin and time-dependent polymers aimed for colonic drug delivery of celecoxib [PDF]
Nanomedicine Journal, 2016 Objective(s):The aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib.
A. Akhgari, M. Hossein Rotubati
doaj +1 more source
Preparation and in-vitro evaluation of fluorometholone cubosomes for ocular delivery [PDF]
Nanomedicine Journal, 2023 Objective(s): In this study, ocular drug delivery systems with a dispersed lipid liquid crystal (cubosomes) containing fluorometholone were used for sustained release and increased permeability to the eye.Materials and Methods: To obtain the best ...
Bizhan Malaekeh-Nikouei +4 more
doaj +1 more source
Size-Tunable Strategies for a Tumor Targeted Drug Delivery System
ACS Central Science, 2020 Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor effects are not always satisfactory due to the limited penetration and retention.
Wen-Qi Yu +3 more
semanticscholar +1 more source
Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates
Scientific Reports, 2017 Tumor-targeted carriers provide efficient delivery of chemotherapeutic agents to tumor tissue. CGKRK is one of the well-known tumor targeting peptides with significant specificity for angiogenic blood vessels and tumor cells. Here, we designed fatty acyl
Meenakshi Sharma +5 more
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Pharmaceuticals, 2023 Fungal infections remain a significant concern for human health. The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial ...
Naiera M. Helmy, Keykavous Parang
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Synthetic cells with self-activating optogenetic proteins communicate with natural cells
Nature Communications, 2022 Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.
Omer Adir +15 more
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Preparation and Characterization of Undecylenoyl Phenylalanine Loaded-Nanostructure Lipid Carriers (NLCs) as a New α-MSH Antagonist and Antityrosinase Agent [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: The aim of this study was to characterize the undecylenoyl phenylalanine (Sepiwhite (SEPI))-loaded nanostructured lipid carriers (NLCs) as a new antimelanogenesis compound.
Mohadeseh Sadat Vaziri +5 more
doaj +1 more source
Molecules, 2020 Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and interferes with the action of RNA-dependent RNA polymerase of SARS-COV-
Keykavous Parang +3 more
doaj +1 more source
Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative colitis. However, the majority of orally administered 4-ASA is
Fatemeh Sadeghi +5 more
doaj +1 more source
Review targeted drug delivery systems for norcantharidin in cancer therapy
Journal of Nanobiotechnology, 2022 Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main anticancer active ingredient isolated from traditional Chinese medicine Mylabris.
Bingtao Zhai +8 more
semanticscholar +1 more source