Results 41 to 50 of about 4,076,090 (289)

Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative colitis. However, the majority of orally administered 4-ASA is
Fatemeh Sadeghi, Atie Eidizade, Farinaz Saremnejad, Farzin Hadizadeh, Elham Khodaverdi, Abbas Akhgari   +5 more
doaj   +1 more source

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery.

, 2020
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana, Memvanga, Patrick, Aristote B. Buya, Véronique Préat, Buya, Aristote Banzenga, Ana Beloqui, Préat, Véronique, Patrick B. Memvanga   +7 more
core   +1 more source

Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Rosa × damascena Herrm. belonging to the Rosaceae family has demonstrated anti-inflammatory and anti-oxidant effects previously. Excessive production of free radicals and activation of tyrosinase enzyme caused by UV induces excessive ...
Elham Hadipour, Mona Rezazadeh Kafash, Seyed Ahmad Emami, Javad Asili, Zahra Boghrati, Zahra Tayarani-Najaran   +5 more
doaj   +1 more source

Aptamers as Smart Ligands for Targeted Drug Delivery in Cancer Therapy

, 2022
Undesirable side effects and multidrug tolerance are the main holdbacks to the treatment of cancer in conventional chemotherapy. Fortunately, targeted drug delivery can improve the enrichment of drugs at the target site and reduce toxicity to normal ...
Wang, Rongjie, Jin Wang, Zhou, Yuxin, Wang, Jin, Chen, Zhenhua, Zongyi Wei, Rongjie Wang, Zhenhua Chen, Yuxin Zhou, Wei, Zongyi   +9 more
core   +1 more source

Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy [PDF]

, 2023
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through bioconjugation of a ligand, drug and/or cell.
Mark A. Borden, J. Angel Navarro-Becerra, Borden, Mark A, Navarro-Becerra, J Angel   +3 more
core   +1 more source

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Molecules, 2019
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

Pharmaceuticals, 2020
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes.
Muhammad Imran Sajid, Muhammad Moazzam, Shun Kato, Kayley Yeseom Cho, Rakesh Kumar Tiwari   +4 more
doaj   +1 more source

Efficient Intracellular Delivery of Cell-Impermeable Cargo Molecules by Peptides Containing Tryptophan and Histidine

Molecules, 2018
We have previously evaluated and reported numerous classes of linear and cyclic peptides containing hydrophobic and hydrophilic segments for intracellular delivery of multiple molecular cargos.
Amir Nasrolahi Shirazi, Saghar Mozaffari, Rinzhin Tshering Sherpa, Rakesh Tiwari, Keykavous Parang   +4 more
doaj   +1 more source

Comparative Molecular Transporter Properties of Cyclic Peptides Containing Tryptophan and Arginine Residues Formed through Disulfide Cyclization

Molecules, 2020
We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as molecular transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation
Eman H. M. Mohammed, Dindyal Mandal, Saghar Mozaffari, Magdy Abdel-Hamied Zahran, Amany Mostafa Osman, Rakesh Kumar Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery

Pharmaceutics, 2020
A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase methodology.
Amir Nasrolahi Shirazi, Shang Eun Park, Shirin Rad, Luiza Baloyan, Dindyal Mandal, Muhammad Imran Sajid, Ryley Hall, Sandeep Lohan, Khalid Zoghebi, Keykavous Parang, Rakesh Kumar Tiwari   +10 more
doaj   +1 more source