Results 21 to 30 of about 1,487,644 (266)
The blood–brain barrier: Structure, regulation and drug delivery
Signal Transduction and Targeted Therapy, 2023 Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu +5 more
semanticscholar +1 more source
Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy
Pharmaceutics, 2023 Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile, weaken their undesirable side effects on normal cells or tissues. In
Jian-Min Li +7 more
semanticscholar +1 more source
Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery
Pharmaceutics, 2022 Recent approvals of siRNA-based products motivated the scientific community to explore siRNA as a treatment option for several intractable ailments, especially cancer.
Muhammad Imran Sajid +5 more
doaj +1 more source
Frontiers in Medical Technology, 2023 Cancer is a life-threatening disease, resulting in nearly 10 million deaths worldwide. There are various causes of cancer, and the prognostic information varies in each patient because of unique molecular signatures in the human body.
Kalpataru Das, C. J
semanticscholar +1 more source
Functionalized liposomes for targeted breast cancer drug delivery
Bioactive Materials, 2023 Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide.
Janske Nel +8 more
semanticscholar +1 more source
Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines
Pharmaceutics, 2023 RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging.
Dindyal Mandal +6 more
doaj +1 more source
Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches
Pharmaceutics, 2022 Mitochondria are implicated in a wide range of functions apart from ATP generation, and, therefore, constitute one of the most important organelles of cell.
Tanzeel Khan +7 more
semanticscholar +1 more source
Cells, 2022 Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired resistance are major drawbacks, limiting its clinical application.
Khalid Zoghebi +3 more
doaj +1 more source
The roles of microRNA families in hepatic fibrosis
Cell & Bioscience, 2017 When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis.
Xue-Ping Jiang +4 more
doaj +1 more source
Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds
Molecules, 2023 The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore ...
Shilpi Gupta +5 more
doaj +1 more source