Results 11 to 20 of about 1,487,644 (266)
Targeted Drug Delivery Strategies for Precision Medicines
Nature Reviews Materials, 2021 Progress in the field of precision medicine has changed the landscape of cancer therapy. Precision medicine is propelled by technologies that enable molecular profiling, genomic analysis and optimized drug design to tailor treatments for individual ...
Mandana T Manzari +2 more
exaly +2 more sources
Hydrogels and Their Applications in Targeted Drug Delivery
Molecules, 2019 Conventional drug delivery approaches are plagued by issues pertaining to systemic toxicity and repeated dosing. Hydrogels offer convenient drug delivery vehicles to ensure these disadvantages are minimized and the therapeutic benefits from the drug are ...
Vladimir Torchilin
exaly +2 more sources
Engineering exosomes for targeted drug delivery
Theranostics, 2021 Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be incorporated into exosomes and then delivered to specific types of cells or ...
Yu-Jie Liang +3 more
semanticscholar +1 more source
Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride [PDF]
Nanomedicine Journal, 2015 Objective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in ...
Sahar Mohamaddoust Aliabadi +4 more
doaj +1 more source
Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma
Molecules, 2022 Human malignant melanoma exhibits imbalances in redox status, leading to activation of many redox-sensitive signaling pathways. APE/Ref-1 is a multifunctional protein that serves as a redox chaperone that regulates many nuclear transcription factors and ...
Razan Alhazmi +9 more
doaj +1 more source
The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate CellsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both contribute to cirrhosis.
Lin-Yan Wan +23 more
doaj +1 more source
Pharmaceuticals, 2023 The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins.
Jonathan Moreno +6 more
doaj +1 more source
Advances in nanomaterial-based targeted drug delivery systems
Frontiers in Bioengineering and Biotechnology, 2023 Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties.
Xiaoxiao Cheng, Qirong Xie, Yang Sun
semanticscholar +1 more source
Advanced NanoBiomed Research, 2022 Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex‐related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the single cell.
Maria Poley +12 more
doaj +1 more source
Cells, 2022 A series of cyclic peptides, [(DipR)(WR)4], [(DipR)2(WR)3], [(DipR)3(WR)2], [(DipR)4(WR)], and [DipR]5, and their linear counterparts containing arginine (R) as positively charged residues and tryptophan (W) or diphenylalanine (Dip) as hydrophobic ...
David Salehi +6 more
doaj +1 more source