Results 61 to 70 of about 1,487,644 (266)

Comparative Molecular Transporter Properties of Cyclic Peptides Containing Tryptophan and Arginine Residues Formed through Disulfide Cyclization

Molecules, 2020
We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as molecular transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation
Eman H. M. Mohammed, Dindyal Mandal, Saghar Mozaffari, Magdy Abdel-Hamied Zahran, Amany Mostafa Osman, Rakesh Kumar Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Nanoparticle-based targeted drug delivery

Experimental and molecular pathology (Print), 2009
Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the “nanometer” size range.
Rajesh K. Singh, James W. Lillard
semanticscholar   +1 more source

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery

Pharmaceutics, 2020
A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase methodology.
Amir Nasrolahi Shirazi, Shang Eun Park, Shirin Rad, Luiza Baloyan, Dindyal Mandal, Muhammad Imran Sajid, Ryley Hall, Sandeep Lohan, Khalid Zoghebi, Keykavous Parang, Rakesh Kumar Tiwari   +10 more
doaj   +1 more source

Preparation and Identification of Magnetic Iron Nanoparticle based ona Natural Hydrogel and its Performance in Targeted Drug Delivery

International Journal of Innovative Science and Research Technology
Billions of dollars are spent annually in the world to treat and investigate problems caused by drug side effects. According to the estimates of health researchers, about 40%of people who take medicine suffer from side effects. In this way, the necessity
Vahid Hosseini, Seyed Masoud Ghoreishi Mokri, Dalia hafezghoran, Bahareh Karimi, Anastasia Aleksandrovna Anashkina, Anna Borisovna Yazykova   +5 more
semanticscholar   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery.

Advanced Drug Delivery Reviews
Ultrasound-responsive agents have shown great potential as targeted drug delivery agents, effectively augmenting cell permeability and facilitating drug absorption. This review focuses on two specific agents, microbubbles and nanodroplets, and provides a
G. Shakya, Marco Cattaneo, Giulia Guerriero, Anunay Prasanna, Samuele Fiorini, O. Supponen   +5 more
semanticscholar   +1 more source

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Pharmaceutics, 2020
Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to ...
Sang-Hoon Lee, R. Bajracharya, J. Min, Ji-Won Han, Byeong Ju Park, Hyo-Kyung Han   +5 more
semanticscholar   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Cyclic Peptide-Gadolinium Nanocomplexes as siRNA Delivery Tools

Pharmaceuticals, 2021
We have recently reported that a cyclic peptide containing five tryptophan, five arginine, and one cysteine amino acids [(WR)5C], was able to produce peptide-capped gadolinium nanoparticles, [(WR)5C]-GdNPs, in the range of 240 to 260 nm upon mixing with ...
Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Dindyal Mandal, David Stickley, Stephanie Nagasawa, Joshua Long, Sandeep Lohan, Keykavous Parang, Rakesh Kumar Tiwari   +8 more
doaj   +1 more source

TARGETED DRUG DELIVERY SYSTEM: A REVIEW

International Research Journal of Modernization in Engineering Technology and Science
Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.
Gupta Manish, Sharma Vimukta
semanticscholar   +1 more source