Results 51 to 60 of about 1,487,644 (266)

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Molecules, 2019
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Rosa × damascena Herrm. belonging to the Rosaceae family has demonstrated anti-inflammatory and anti-oxidant effects previously. Excessive production of free radicals and activation of tyrosinase enzyme caused by UV induces excessive ...
Elham Hadipour, Mona Rezazadeh Kafash, Seyed Ahmad Emami, Javad Asili, Zahra Boghrati, Zahra Tayarani-Najaran   +5 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Homochiral Peptides Containing Arginine and Histidine as Molecular Transporters

Molecules, 2018
Linear (HR)n and cyclic [HR]n peptides (n = 4,5) containing alternate arginine and histidine residues were synthesized. The peptides showed 0–15% cytotoxicity at 5–100 µM in human ovarian adenocarcinoma (SK-OV-3) cells while they ...
Naglaa Salem El-Sayed, Taryn Miyake, Amir N. Shirazi, Shang Eun Park, Jimmy Clark, Stephani Buchholz, Keykavous Parang, Rakesh Tiwari   +7 more
doaj   +1 more source

Polymeric Nanoparticles in Targeted Drug Delivery: Unveiling the Impact of Polymer Characterization and Fabrication

Polymers
Polymeric nanoparticles (PNPs) represent a groundbreaking advancement in targeted drug delivery, offering significant benefits over conventional systems.
L. Eltaib
semanticscholar   +1 more source

Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery

Pharmaceutics, 2021
The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs.
Lu Tang, Jing Li, Qingqing Zhao, Ting Pan, Hui Zhong, Wen Wang   +5 more
semanticscholar   +1 more source

Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

Pharmaceuticals, 2020
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes.
Muhammad Imran Sajid, Muhammad Moazzam, Shun Kato, Kayley Yeseom Cho, Rakesh Kumar Tiwari   +4 more
doaj   +1 more source

Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm

Frontiers in Cellular and Infection Microbiology, 2022
Treatment of Staphylococcus aureus biofilm infections using conventional antibiotic therapy is challenging as only doses that are sublethal to the biofilm can be administered safely to patients.
P. Ommen, Line Hansen, Bente K. Hansen, H. Vu-Quang, J. Kjems, R. Meyer   +5 more
semanticscholar   +1 more source

Artificial Intelligence‐Driven Nanoarchitectonics for Smart Targeted Drug Delivery

Advances in Materials
The development of data‐driven and targeted drug delivery systems is essential for advancing precision therapeutics. Despite substantial progress in nanocarrier development, conventional platforms continue to face major challenges in clinical translation
Hayeon Bae, H. Ji, Konstantin Konstantinov, Ronald Sluyter, Katsuhiko Ariga, Yong Ho Kim, Jung Ho Kim   +6 more
semanticscholar   +1 more source

Potential use of exosomes as diagnostic biomarker and in targeted drug delivery: progress in clinical and preclinical application

ACS Biomaterials Science & Engineering, 2021
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They are typically range in size 30–150 nm in diameter.
Md Nurul Huda, M. Nafiujjaman, Isaac G. Deaguero, Jude Okonkwo, M. Hill, Taeho Kim, M. Nurunnabi   +6 more
semanticscholar   +1 more source

Efficient Intracellular Delivery of Cell-Impermeable Cargo Molecules by Peptides Containing Tryptophan and Histidine

Molecules, 2018
We have previously evaluated and reported numerous classes of linear and cyclic peptides containing hydrophobic and hydrophilic segments for intracellular delivery of multiple molecular cargos.
Amir Nasrolahi Shirazi, Saghar Mozaffari, Rinzhin Tshering Sherpa, Rakesh Tiwari, Keykavous Parang   +4 more
doaj   +1 more source