Results 61 to 70 of about 70,301 (300)

Drug Delivery Systems for Infectious Eye Diseases: Advancements and Prospects

Journal of Nanotheranostics
Infectious ocular diseases like keratitis, conjunctivitis, and endophthalmitis pose significant clinical challenges due to the complexities of delivering drugs to the eye.
Binapani Mahaling, Namrata Baruah, Aumreetam Dinabandhu   +2 more
doaj   +1 more source

Nanotechnology approaches for ocular drug delivery

Middle East African Journal of Ophthalmology, 2013
Blindness is a major health concern worldwide that has a powerful impact on afflicted individuals and their families, and is associated with enormous socio-economical consequences. The Middle East is heavily impacted by blindness, and the problem there is augmented by an increasing incidence of diabetes in the population.
Xu, Qingguo, Kambhampati, Siva P., Kannan, Rangaramanujam M.   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comprehensive Strategies for Overcoming Barriers in Ocular Drug Delivery: Current Trends and Future Directions

Biomedical Sciences and Clinical Medicine
The human eye is a complex and sensitive organ, making effective drug delivery a major challenge. Its anatomical barriers, such as the precorneal, corneal, and blood-ocular barriers, significantly limit drug penetration and retention.
Elavarasan N, S. Revathi, K. Venkateshwaran   +2 more
doaj   +1 more source

Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices [PDF]

, 2017
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies,
Acheampong A, Bar-Ilan A, Do MP, Forrester JV, Gasmi H, Giannaccare G, Lin MC, Nijhawan R, Patel PB, Pratt NL, Schaeffer HE, Schopf LR, Smolin G, Song HB, Waltman SR, Wei J, Wheeler J, Xu X   +17 more
core   +2 more sources

Nanoliposomal minocycline for ocular drug delivery [PDF]

Nanomedicine: Nanotechnology, Biology and Medicine, 2013
Nanoliposomal technology is a promising drug delivery system that could be employed to improve the pharmacokinetic properties of clearance and distribution in ocular drug delivery to the retina. We developed a nanoscale version of an anionic, cholesterol-fusing liposome that can encapsulate therapeutic levels of minocycline capable of drug delivery. We
James M, Kaiser, Hisanori, Imai, Jeremy K, Haakenson, Robert M, Brucklacher, Todd E, Fox, Sriram S, Shanmugavelandy, Kellee A, Unrath, Michelle M, Pedersen, Pingqi, Dai, Willard M, Freeman, Sarah K, Bronson, Thomas W, Gardner, Mark, Kester   +12 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Computational Study of Hydrogel Ring Device for Ocular Drug Delivery [PDF]

, 2018
Researchers have developed many different kinds of ocular drug delivery devices. However, most address anterior eye disorders—very few are designed specifically for the treatment of posterior eye diseases.
Hanif, Sarah, Lim, Abigail, Sit, Hilarie, Tan, Wan Qing Melissa   +3 more
core  

Microemulsions as drug delivery systems for topical ocular administration [PDF]

, 2003
The conventional ophthalmic dosage forms are relatively simple: usually, water-soluble drugs are delivered in aqueous solution and water-insoluble drugs are prepared as suspensions or ointments. However, these delivery systems currently used present very
Carneiro, Luciana Barbosa, Cunha Júnior, Armando Da Silva, Fialho, Sílvia Ligório, Oréfice, Fernando   +3 more
core   +3 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source