Results 81 to 90 of about 70,301 (300)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Lamellar Structures of MUC2-Rich Mucin: A Potential Role in Governing the Barrier and Lubricating Functions of Intestinal Mucus [PDF]

, 2012
Mucus is a ubiquitous feature of mammalian wet epithelial surfaces, where it lubricates and forms a selective barrier that excludes a range of particulates, including pathogens, while hosting a diverse commensal microflora.
Garcia De La Torre, Angela, MacIerzanka, Adam, MacKie, Alan R., Mills, Clare, Mills, E. N Clare, Rigby, Neil M., Round, Andrew N.   +6 more
core   +1 more source

Microneedles for advanced ocular drug delivery

Advanced Drug Delivery Reviews, 2023
In the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, whileintraocular injectionsare the current gold standard treatment option for treating posterior segment diseases. Nonetheless, topical eye drops are associated with low bioavailability (
Glover, Katie, Mishra, Deepakkumar, Gade, Shilpkala, Vora, Lalitkumar K., Wu, Yu, Paredes, Alejandro J., Donnelly, Ryan F., Singh, Thakur Raghu Raj   +7 more
openaire   +4 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science
Pathological retinal and choroidal neovascularization is a hallmark of several blinding diseases, including diabetic retinopathy and age‐related macular degeneration.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
doaj   +1 more source

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue.
Andreza Maria Ribeiro, Ana Figueiras, Francisco Veiga   +2 more
doaj   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Long‐Acting Ocular Injectables: Are We Looking In The Right Direction?

Advanced Science
The complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability.
Mickael Dang, Molly S. Shoichet
doaj   +1 more source

Simple one-pot fabrication of ultra-stable core-shell superparamagnetic nanoparticles for potential application in drug delivery [PDF]

, 2012
Ultrastable superparamagnetic core-shell nanoparticles of average diameter 80 nm have been fabricated via a simple one-pot method involving superparamagnetic iron oxide nanoparticles (SPIONs) core ([similar]50 nm in diameter) and lipid bilayer shell by ...
Al-Jamal, Allen, Brahler, Bruce, Chetoni, Cheung, De Cuyper, Gabizon, Gaihre, Goodwin, Gupta, Hou, Jarrett, Juliano, Kim, Langer, Laurent, Liu, Mahmoudi, Mahmoudi, Mahmoudi, Mahmoudi, Mahmoudi, Mart, Massart, Meincke, Mezei, Pankhurst, Pauser, Perez, Philipse, Poste, Pradhan, Prozorov, Sasaki, Sen, Sen, Sen, Sharifi, Soenen, Soenen, Tartaj, Tokunaga, Zalipsky   +43 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source