Results 221 to 230 of about 436,888 (278)

Artificial Intelligence Resources for the Screening of Titles and Abstracts in Systematic Reviews: A Scoping Review

Cochrane Evidence Synthesis and Methods, Volume 4, Issue 5, September 2026.
ABSTRACT Introduction Artificial intelligence (AI) is a branch of technology enabling machines to emulate complex human skills; it can also entail problem‐solving using bioinspired methods. It is used for automating systematic literature reviews (SLR), that is, defining a clinical question, locating relevant literature, preliminary screening, study ...
Ana M. Barragán, Sara Elena Ortiz Bonett, Eliana‐Isabel Rodríguez‐Grande, Alvaro David Orjuela‐Cañón, Oscar J. Perdomo, Guillermo Sánchez‐Vanegas   +5 more
wiley   +1 more source

Stereodivergent Synthesis of C5‐α‐Substituted Linezolid Derivatives From D‐Mannitol and Structure–Antibacterial Activity Evaluation

Chirality, Volume 38, Issue 9, September 2026.
A stereodivergent route from D‐mannitol enables access to enantiopure C5‐α‐substituted linezolid analogues with full configurational control. Biological evaluation reveals that α‐substitution abolishes antibacterial activity irrespective of stereochemistry, establishing a strict steric limitation at C5 and highlighting the dominant role of substituent ...
José A. Gálvez, Laura Sanz‐Asensio, Ramón Badorrey, Jesús Gonzalo‐Asensio   +3 more
wiley   +1 more source

Use of Artificial Intelligence‐Based Platforms to Support Searches in Evidence Synthesis Studies: A Study of the EAACI Methodology Committee

Clinical and Translational Allergy, Volume 16, Issue 9, September 2026.
ABSTRACT Objective To demonstrate an evaluation of the use of artificial intelligence (AI) in supporting tasks in evidence synthesis (particularly search for primary studies) in the allergy or respirology fields. Methods We queried three AI‐based platforms specialised on identifying scientific publications using several strategies (i.e., prompting ...
Bernardo Sousa‐Pinto, Antonio Bognanni, Paweł Jemioło, Rafael José Vieira, Thinh H. Nguyen, Zachary Munn, Timothy Hugh Barker, Lemma N. Bulto, Danilo di Bona, Jean Bousquet, Mário Dinis‐Ribeiro, João A. Fonseca, Mariette Awad, Manuel Marques‐Cruz, Holger J. Schünemann   +14 more
wiley   +1 more source

Inhibition of METTL14 Alleviates OGD/R‐Induced Neuronal Differentiation Injury in Neural Stem Cells Through Suppressing the Tp53inp2/Ptgs2 Axis: Potential Benefits for the Mouse MCAO Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The graphical abstract highlights that ischemic stroke leads to increased METTL14 expression, which enhances Tp53inp2 mRNA stability through m6A modification. Elevated Tp53inp2 then promotes damaging mitophagy and ROS production by upregulating Ptgs2, ultimately impairing the neuronal differentiation of neural stem cells.
Dan Hou, Yujie Hu, Tian Yun, Dan Yu, Guoshuai Yang   +4 more
wiley   +1 more source

Protocol for a Pilot Quasi‐Experimental Study on the Effect of Patient‐Centered Education on HIV Virological Outcomes Among Adult People Live With HIV‐HBV Co‐Infection in North‐West Ethiopia: Protocol for a Pilot Quasi‐Experimental Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Human immunodeficiency virus (HIV) remains a major public health challenge in sub‐Saharan Africa, including Ethiopia. Adults living with HIV are at increased risk of liver‐related complications, poor treatment outcomes, and suboptimal virological control, particularly when adherence to antiretroviral therapy (ART) is inadequate ...
Mequanente Dagnaw, Destaw Fetene Teshome, Tilahun Bizuayehu Demass, Abebaw Gebyehu Worku   +3 more
wiley   +1 more source

The Importance of QuantiFERON Gold Plus Test for the Diagnosis of Presumed Ocular Tuberculosis. [PDF]

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Bruzzone F, Plebani M, Koryllou A, Perreau M, Guex-Crosier Y.   +4 more
europepmc   +1 more source

Combination Treatment of IL‐17 Inhibitor and JAK Inhibitor in Psoriatic Arthritis: A Case Report and Scoping Review

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Psoriatic arthritis (PsA) is a chronic inflammatory disease with complex pathophysiology. Despite advancements in biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs), treatment responses remain suboptimal for many patients.
Mengduan Pang, Ling Li, Qi Zhang, Min Zhao   +3 more
wiley   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

One Model to Dose Them All: A Population Pharmacokinetic Model for Multiple Aminoglycosides Across the Human Lifespan

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Aminoglycosides require therapeutic drug monitoring due to substantial pharmacokinetic variability across individuals. While population pharmacokinetic (popPK) models have been developed for individual drugs across age groups, and cross‐drug maturation models have been explored, it is unclear whether pooling data across aminoglycosides ...
Dominic M. H. Tong, Jonathan D. Faldasz, Ron J. Keizer, Jasmine H. Hughes   +3 more
wiley   +1 more source

Volumetric Microsampling for Patient‐Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Accurate drug concentration measurement is essential for precision pharmacotherapy, but conventional therapeutic drug monitoring (TDM) requires venous sampling, increasing patient burden, and potentially limiting participation in TDM and model‐informed precision dosing (MIPD).
Hari Prabhath Tummala, Abbie D. Leino, Nathaniel J. Rhodes, Kevin J. Downes, Marc H. Scheetz, Manjunath P. Pai   +5 more
wiley   +1 more source