Results 61 to 70 of about 11,439 (266)

Silencing VEGFR-2 Hampers Odontoblastic Differentiation of Dental Pulp Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Dental pulp stem cells (DPSCs) are a source of postnatal stem cells essential for maintenance and regeneration of dentin and pulp tissues. Previous in vivo transplantation studies have shown that DPSCs are able to give rise to odontoblast-like cells ...
Kajohnkiart Janebodin, Kajohnkiart Janebodin, Kajohnkiart Janebodin, Rakchanok Chavanachat, Aislinn Hays, Aislinn Hays, Aislinn Hays, Morayma Reyes Gil   +7 more
doaj   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Novel Roles of Nestin in Postnatal Root Formation

Dentistry Journal
Background/Objectives: Nestin is an intermediate filament protein and a marker of odontoblasts, but its function in tooth and bone formation is largely unknown.
Yan Jing, Jinqiu Wu, Ying Liu, Xiaohua Liu, Chi Ma   +4 more
doaj   +1 more source

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

Frontiers in Dental Medicine, 2023
Over 90% of the U.S. adult population suffers from tooth structure loss due to caries. Most of the mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells known as odontoblasts.
Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker   +47 more
doaj   +1 more source

Deferoxamine-Induced Migration and Odontoblast Differentiation via ROS-Dependent Autophagy in Dental Pulp Stem Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: As a vital degradation and recycling system, autophagy plays an essential role in regulating the differentiation of stem cells. We previously showed that iron chelator deferoxamine (DFO) could promote the repair ability of dental pulp ...
Xuan Wang, Tian-tian Wu, Long Jiang, D. Rong, Ya-qin Zhu   +4 more
semanticscholar   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping

Environmental Toxicology, EarlyView.
ABSTRACT This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal ...
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima   +8 more
wiley   +1 more source

Piezo‐type mechanosensitive cation channel 1 in bone biomechanics and its multidimensional distribution characteristics in skeletal tissue

VIEW, EarlyView.
PIEZO1 is highly correlated with mechanical stimulation, controlling bone growth and remodeling, while showing specific distribution characteristics under distinct loads. Upon dialectical review, this manuscript proposes that PIEZO1 could serve as a target for osteoporosis and a quantitative indicator for monitoring bone health in real‐time.
Chunyu Zhang, Yuehong Wang
wiley   +1 more source

mTORC1 regulates exosomes release from odontoblasts to regulate DPSCs odontoblastic differentiation

, 2022
Abstract Dental pulp stem cells (DPSCs) are the crucial part of dentin-pulp complex regeneration. A further understanding of the mechanism of how DPSCs stay in a quiescent state can contribute to improvements in dentin-pulp complex and dentinogenesis.
Xinghong Luo, Weiqing Feng, Shijiang Huang, Shenghong Miao, Tao Jiang, Qian Lei, Sheng Zhang, Xiaochun Bai, Chunbo Hao, Weizhong Li, Dandan Ma   +10 more
openaire   +1 more source

Autophagy regulates odontoblast differentiation by suppressing NF-κB activation in an inflammatory environment

Cell Death and Disease, 2016
Odontoblasts are derived from dental papilla mesenchymal cells and have an important role in defense against bacterial infection, whereas autophagy can recycle long-lived proteins and damaged organelles to sustain cellular homeostasis.
F. Pei, Huan Wang, Zhaowei Chen, Lu Zhang   +3 more
semanticscholar   +1 more source