Results 61 to 70 of about 15,982 (300)

FAM20C Modulates Neuronal Differentiation in Hypoxic–Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A‐Dependent H3K9me3 Regulation

Cell Proliferation, EarlyView.
FAM20C regulates the composition of the YTHDC1‐NCL‐KAP1‐LINE1 RNAs complex, thereby affecting neuronal differentiation in hypoxic–ischemic brain damage (HIBD). ABSTRACT Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets.
Chen‐xi Feng, Mei Wang, Gen Li, Si‐jia Chu, Di Wu, Xiao‐han Hu, Li‐xiao Xu, Mei Li, Xing Feng   +8 more
wiley   +1 more source

Mild heat stress promotes the differentiation of odontoblast-like MDPC-23 cells via yes-associated protein

International Journal of Hyperthermia
Purpose Dentin hypersensitivity (DH) is a prevalent condition, but long-term effective treatments are scarce. Differentiation of odontoblast-like cells is promising for inducing tertiary dentinogenesis and ensuring sustained therapeutic efficacy against ...
Peiqi Liu, Zhen Li, Hui Zhang, Yijie Wang, Yuxin Liao, Yi Guo, Chenxu Wang, Yuanwu Zou, Rui Zou, Lin Niu   +9 more
doaj   +1 more source

Odontoblasts release exosomes to regulate the odontoblastic differentiation of dental pulp stem cells

Stem Cell Research & Therapy, 2023
Abstract Background Dental pulp stem cells (DPSCs) play a crucial role in dentin-pulp complex regeneration. Further understanding of the mechanism by which DPSCs remain in a quiescent state could contribute to improvements in the dentin-pulp complex and dentinogenesis. Methods
Xinghong Luo, Weiqing Feng, Shijiang Huang, Shenghong Miao, Tao Jiang, Qian Lei, Jingyao Yin, Sheng Zhang, Xiaochun Bai, Chunbo Hao, Weizhong Li, Dandan Ma   +11 more
openaire   +3 more sources

Construction of Recombinant Plasmid PcDNA3.1/BMP-2 and Its Involvement in Differentiation of Human Dental Pulp-Derived Cells Into an Odontoblastic Lineage [PDF]

, 2009
Experimental studies have shown that dental pulp tissue has potential to regenerate dentine in response to adverse stimuli, such as caries and associated operative procedures.
Bachtiar, B. M. (Boy), Bachtiar, E. W. (Endang), Joenoes, H. (Hedijanti), Yuniastuti, M. (Mindia)   +3 more
core   +1 more source

Distinctive Genetic Activity Pattern of the Human Dental Pulp between Deciduous and Permanent Teeth [PDF]

, 2014
published_or_final_versio
Baik, HS, Jin, C, Jung, HS, Lee, JM, Lee, MJ, Li, L, Tang, Q   +6 more
core   +1 more source

Modulation of primary human apical papilla stem cells: Influence of Enterococcus faecalis, oxygen levels, and calcium silicate‐based cements

European Journal of Oral Sciences, EarlyView.
Abstract Stem cells from the apical papilla (SCAP) are essential for regenerative endodontic treatment. Although mineral trioxide aggregate (MTA) and Biodentine are widely used in regenerative endodontic treatment procedures, their effects on SCAP remain unclear.
Olena Rakhimova, Valeriia Zymovets, Lahood Abdalla, Bagir Soltani, Malin Brundin, Peyman Kelk, Nelly Romani Vestman   +6 more
wiley   +1 more source

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

Frontiers in Dental Medicine, 2023
Over 90% of the U.S. adult population suffers from tooth structure loss due to caries. Most of the mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells known as odontoblasts.
Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker   +47 more
doaj   +1 more source

Autophagy regulates odontoblast differentiation by suppressing NF-κB activation in an inflammatory environment

Cell Death and Disease, 2016
Odontoblasts are derived from dental papilla mesenchymal cells and have an important role in defense against bacterial infection, whereas autophagy can recycle long-lived proteins and damaged organelles to sustain cellular homeostasis.
F. Pei, Huan Wang, Zhaowei Chen, Lu Zhang   +3 more
semanticscholar   +1 more source

Interleukin-1 beta and interleukin-8 in healthy and inflamed dental pulps [PDF]

, 2009
After aggression to the dental pulp, some cells produce cytokines in order to start and control the inflammatory process. Among these cytokines, interleukin-1 beta (IL-1β) and interleukin-8 (IL-8) emerge as important ones.
CAMPOS, Marcia Sampaio, CAVALCANTI, Bruno Neves, FARIA, Miriam Rubio, FONTES, Alexandra, SILVA, Alessandra Cecília Oliveira   +4 more
core   +3 more sources

Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

The FEBS Journal, EarlyView.
The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura, Hannah M. Nakamura, Yasumasa Iwasaki, Motomi Enomoto‐Iwamoto, Noriaki Nakashima, Satoshi Fukumoto, Maurizio Pacifici, Masahiro Iwamoto, Minoru Wakamori   +8 more
wiley   +1 more source