Results 61 to 70 of about 10,119 (237)

Biochemical bone biomarkers in plasma cell dyscrasias

British Journal of Haematology, EarlyView.
Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador, Rohit Vijjhalwar, Muhammad Kassim Javaid, Claire M. Edwards, Karthik Ramasamy   +4 more
wiley   +1 more source

Genome-wide association Scan of dental caries in the permanent dentition [PDF]

, 2012
Background: Over 90% of adults aged 20 years or older with permanent teeth have suffered from dental caries leading to pain, infection, or even tooth loss.
Anjomshoaa, Ida, Beck, James C, Begum, Ferdouse, Boerwinkle, Eric, Cornelis, Marilyn, Crosslin, David R, Crout, Richard, Cuenco, Karen T, Doheny, Kimberly F, Feingold, Eleanor, Hu, Frank B., Laurie, Cathy C, Lee, Myoung-Keun, Marazita, Mary L, McNeil, Daniel W, Nelson, Sarah C, Noel, Jacqueline, Polk, Deborah E, Pugh, Elizabeth W, Shaffer, John R, Vieira, Alexandre R, Wang, Xiaojing, Weeks, Daniel E, Weyant, Robert J, Zeng, Zhen   +24 more
core   +6 more sources

Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia

Clinical Genetics, EarlyView.
Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise, Benkirane‐Jessel Nadia, Anton Nicolas, Vandamme Thierry, Clauss François, Conzatti Guillaume   +5 more
wiley   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

mTORC1 regulates exosomes release from odontoblasts to regulate DPSCs odontoblastic differentiation

, 2022
Abstract Dental pulp stem cells (DPSCs) are the crucial part of dentin-pulp complex regeneration. A further understanding of the mechanism of how DPSCs stay in a quiescent state can contribute to improvements in dentin-pulp complex and dentinogenesis.
Xinghong Luo, Weiqing Feng, Shijiang Huang, Shenghong Miao, Tao Jiang, Qian Lei, Sheng Zhang, Xiaochun Bai, Chunbo Hao, Weizhong Li, Dandan Ma   +10 more
openaire   +1 more source

Evaluation of the performance of ChatGPT‐4 and ChatGPT‐4o as a learning tool in endodontics

International Endodontic Journal, EarlyView.
Abstract Aims The aim of this study was to evaluate the accuracy and consistency of responses given by two different versions of Chat Generative Pre‐trained Transformer (ChatGPT), ChatGPT‐4, and ChatGPT‐4o, to multiple‐choice questions prepared from undergraduate endodontic education topics at different times of the day and on different days ...
Esra Arılı Öztürk, Ceren Turan Gökduman, Burhan Can Çanakçi   +2 more
wiley   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Interpretation of the concepts of dentinal tubule and dentinal canaliculus

Regulatory Mechanisms in Biosystems
The biology of dentin occupies a central place in the theory of tooth integrity as an organ, and knowledge about the microstructure of dentin changes with the development of new research methods, such as scanning electron microscopy.
S. L. Popel, N. O. Gevkaliuk, N. I. Sydliaruk, Y. M. Martyts, M. Y. Pynda, V. Y. Pudyak, V. Y. Krupey   +6 more
doaj   +1 more source

Deep Caries Management: EFCD‐ESE‐ORCA S3‐Level Clinical Practice Guideline

International Endodontic Journal, EarlyView.
ABSTRACT Objective To develop an evidence‐based S3‐level clinical practice guideline for the management of deep and extremely deep caries in vital permanent teeth. Methods An evidence‐based medical guideline based on systematically searched and appraised evidence as well as a structured consensus (S3‐level) was jointly developed by the European ...
Falk Schwendicke, Esra Kosan, Avijit Banerjee, Aylin Baysan, Lars Bjørndal, Laura Ceballos, Henry F. Duncan, Sascha Herbst, Klaus W. Neuhaus, Anne C. O'Connell, Sebastian Paris, Helena Dujic   +11 more
wiley   +1 more source