Results 1 to 10 of about 12,751 (221)

Odontoblasts in Equine Hypsodont Teeth—How They Cope with Permanent Occlusal Wear [PDF]

Animals
Horses’ hypsodont (high-crowned) teeth face permanent dental wear. This is compensated for by a continuous eruption, which requires a high adaptability of odontoblasts; otherwise, the dental pulp would be exposed.
Laura Beate Heilen, Jessica Roßgardt, Jutta Dern-Wieloch, Jörg Vogelsberg, Carsten Staszyk   +4 more
doaj   +2 more sources

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis [PDF]

Advanced Science
Dental pulp responses to dental decay, the most prevalent chronic disease worldwide, involve remodeling processes comparable to those observed in other human diseases.
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
doaj   +2 more sources

Membrana preformativa: Unveiling the unexplored facets of dental development [PDF]

Journal of Oral Biology and Craniofacial Research
Aim: Odontogenesis is a complex and highly regulated biological process that involves a range of molecular mechanisms. Among these, Ki67 and Cyclin D1 are crucial cell cycle regulators that play pivotal roles in controlling cell proliferation during ...
Sakshi Sikaria, Suganya Panneer Selvam, Ramya Ramadoss, Sandhya Sundar   +3 more
doaj   +2 more sources

CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts

Frontiers in Cell and Developmental Biology, 2021
Dentin, which composes most of the tooth structure, is formed by odontoblasts, long-lived post-mitotic cells maintained throughout the entire life of the tooth. In mature odontoblasts, however, cellular activity is significantly weakened.
Yeoung-Hyun Park, Yeoung-Hyun Park, Chul Son, You-Mi Seo, Yoon Seon Lee, Alix Har, Joo-Cheol Park, Joo-Cheol Park   +7 more
doaj   +1 more source

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis

Frontiers in Physiology, 2022
Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase
Cheng Tian, Jihua Chai, Weidong Liu, Xinye Zhang, Yashu Li, Huanyan Zuo, Guohua Yuan, Haojian Zhang, Haojian Zhang, Huan Liu, Huan Liu, Zhi Chen, Zhi Chen   +12 more
doaj   +1 more source

Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries

Frontiers in Dental Medicine, 2022
Dental caries is the most common chronic disease in children and adults worldwide. The complex etiology of dental caries includes environmental factors as well as host genetics, which together contribute to inter-individual variation in susceptibility ...
Mairobys Socorro, Priyanka Hoskere, Catherine Roberts, Lyudmila Lukashova, Kostas Verdelis, Kostas Verdelis, Kostas Verdelis, Elia Beniash, Elia Beniash, Dobrawa Napierala, Dobrawa Napierala   +10 more
doaj   +1 more source

circKLF4 Upregulates Klf4 and Endoglin to Promote Odontoblastic Differentiation of Mouse Dental Papilla Cells via Sponging miRNA-1895 and miRNA-5046

Frontiers in Physiology, 2022
circular RNAs (circRNAs) is a broad and diverse endogenous subfamily of non-coding RNAs, regulating the gene expression by acting as a microRNA (miRNA) sponge.
Yue Zhang, Hao Zhang, Guohua Yuan, Guobin Yang   +3 more
doaj   +1 more source

Immunomodulation stimulates the innervation of engineered tooth organ [PDF]

, 2014
The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from
Bécavin, Thibault, Keller, Laetitia, Kuchler-Bopp, Sabine, Kökten, Tunay, Lesot, Hervé, Weikert, Jean-Luc   +5 more
core   +9 more sources

Plasma Membrane Ca²⁺–ATPase in Rat and Human Odontoblasts Mediates Dentin Mineralization

Biomolecules, 2021
Intracellular Ca2+ signaling engendered by Ca2+ influx and mobilization in odontoblasts is critical for dentinogenesis induced by multiple stimuli at the dentin surface.
Maki Kimura, Hiroyuki Mochizuki, Ryouichi Satou, Miyu Iwasaki, Eitoyo Kokubu, Kyosuke Kono, Sachie Nomura, Takeshi Sakurai, Hidetaka Kuroda, Yoshiyuki Shibukawa   +9 more
doaj   +1 more source

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Frontiers in Physiology, 2021
Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in ...
Mayumi Matsunaga, Mayumi Matsunaga, Maki Kimura, Takehito Ouchi, Takashi Nakamura, Sadao Ohyama, Masayuki Ando, Sachie Nomura, Toshifumi Azuma, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +10 more
doaj   +1 more source