Results 11 to 20 of about 18,767 (302)

Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity

Frontiers in Physiology, 2022
According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface.
Sadao Ohyama, Sadao Ohyama, Takehito Ouchi, Maki Kimura, Ryuya Kurashima, Keiko Yasumatsu, Daisuke Nishida, Suzuro Hitomi, Suzuro Hitomi, Sobhan Ubaidus, Hidetaka Kuroda, Hidetaka Kuroda, Shinichirou Ito, Masayuki Takano, Kentaro Ono, Toshihide Mizoguchi, Akira Katakura, Yoshiyuki Shibukawa   +17 more
doaj   +2 more sources

High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts

Frontiers in Physiology, 2018
Odontoblasts play a crucial role in dentin formation and sensory transduction following the application of stimuli to the dentin surface. Various exogenous and endogenous stimuli elicit an increase in the intracellular free calcium concentration ([Ca2+]i)
Maki Kimura, Koichi Nishi, Asuka Higashikawa, Sadao Ohyama, Sadao Ohyama, Kaoru Sakurai, Masakazu Tazaki, Yoshiyuki Shibukawa   +7 more
doaj   +2 more sources

Expression and function of dopamine in odontoblasts [PDF]

Journal of Cellular Physiology, 2019
AbstractDopamine (DA) is produced from tyrosine by tyrosine hydroxylase (TH). A recent study has reported that DA promotes the mineralization of murine preosteoblasts. However, the role of DA in odontoblasts has not been examined. Therefore, in this investigation, we researched the expression of TH and DA in odontoblasts and the effects of DA on the ...
Shoko Fujino, Sayuri Hamano, Atsushi Tomokiyo, Tomohiro Itoyama, Daigaku Hasegawa, Hideki Sugii, Shinichiro Yoshida, Ayako Washio, Aoi Nozu, Taiga Ono, Naohisa Wada, Chiaki Kitamura, Hidefumi Maeda   +12 more
openaire   +4 more sources

Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. [PDF]

PLoS ONE, 2013
Odontoblasts produce dentin during development, throughout life, and in response to pathological conditions by sensing stimulation of exposed dentin. The functional properties and localization patterns of transient receptor potential (TRP) melastatin ...
Maki Tsumura, Ubaidus Sobhan, Masaki Sato, Miyuki Shimada, Akihiro Nishiyama, Aya Kawaguchi, Manabu Soya, Hidetaka Kuroda, Masakazu Tazaki, Yoshiyuki Shibukawa   +9 more
doaj   +2 more sources

The roles of odontoblasts in dental pulp innate immunity

Japanese Dental Science Review, 2018
Summary: Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external ...
Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi Matsuo   +6 more
doaj   +2 more sources

circKLF4 Upregulates Klf4 and Endoglin to Promote Odontoblastic Differentiation of Mouse Dental Papilla Cells via Sponging miRNA-1895 and miRNA-5046

Frontiers in Physiology, 2022
circular RNAs (circRNAs) is a broad and diverse endogenous subfamily of non-coding RNAs, regulating the gene expression by acting as a microRNA (miRNA) sponge.
Yue Zhang, Hao Zhang, Guohua Yuan, Guobin Yang   +3 more
doaj   +1 more source

Pathological dentinogenesis in posteruptiv toot development [PDF]

Stomatološki glasnik Srbije, 2004
The most significant investigations concerning pathological dentinogenesis are reviewed in this article. Previous results point out that odontoblasts behave, either in physiological or pathological circumstances, in the genetically determined sequence of
Vojinović Jovan, Stevanović Radoje
doaj   +1 more source

Plasma Membrane Ca²⁺–ATPase in Rat and Human Odontoblasts Mediates Dentin Mineralization

Biomolecules, 2021
Intracellular Ca2+ signaling engendered by Ca2+ influx and mobilization in odontoblasts is critical for dentinogenesis induced by multiple stimuli at the dentin surface.
Maki Kimura, Hiroyuki Mochizuki, Ryouichi Satou, Miyu Iwasaki, Eitoyo Kokubu, Kyosuke Kono, Sachie Nomura, Takeshi Sakurai, Hidetaka Kuroda, Yoshiyuki Shibukawa   +9 more
doaj   +1 more source

Immunomodulation stimulates the innervation of engineered tooth organ [PDF]

, 2014
The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from
Bécavin, Thibault, Keller, Laetitia, Kuchler-Bopp, Sabine, Kökten, Tunay, Lesot, Hervé, Weikert, Jean-Luc   +5 more
core   +9 more sources

Functional Expression of IP, 5-HT₄, D₁, A_2A, and VIP Receptors in Human Odontoblast Cell Line

Biomolecules, 2023
Odontoblasts are involved in sensory generation as sensory receptor cells and in dentin formation. We previously reported that an increase in intracellular cAMP levels by cannabinoid 1 receptor activation induces Ca2+ influx via transient receptor ...
Eri Kitayama, Maki Kimura, Takehito Ouchi, Masahiro Furusawa, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source