Results 91 to 100 of about 13,860,386 (295)

Seed and non-seed region-dependent off-target effect analyses for siVIM-270 and siVIM-805.

, 2015
(A, B) Expression profiles of off-target genes with 3’UTR sequences that perfectly match the corresponding siRNA seed region (i.e. off-targets) were compared to genes without such sequence. (C, D) The correlation between GC content in all the subsections
Tomoko Takahashi (409474), Paul A. Wilson (826326), Yuko Nakano (836788), Piotr J. Kamola (116079), Kumiko Ui-Tei (10014)   +4 more
core   +1 more source

Comprehensive computational analysis of epigenetic descriptors affecting CRISPR-Cas9 off-target activity

BMC Genomics, 2022
Background A common issue in CRISPR-Cas9 genome editing is off-target activity, which prevents the widespread use of CRISPR-Cas9 in medical applications.
Jeffrey K. Mak, Florian Störtz, Peter Minary   +2 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

The Effect of Target Transparency on Managers’ Target Setting Decisions

, 2020
This study investigates via an experiment the effects of target transparency on managers’ target setting decisions. Specifically, we investigate whether target transparency, which reflects employees’ knowledge about each other’s targets, affects managers’
Artz, Martin, Arnold, Markus C., Tafkov, Ivo   +2 more
core  

CRISPR/Cas9 from bench to bedside: what clinicians need to know before application?

Military Medical Research, 2020
In October 2020, Dr. Emmanuelle Charpentier and Dr. Jennifer Doudna won the Nobel Prize in Chemistry for their pioneering work in precise genome editing using the CRISPR technology.
Zi-Qing Li, Chao-Hong Li
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Off-target pileups from the whole benchmark experiment data set.

Off-target pileups from the whole benchmark experiment data set.
Hiroki Shiomi (718724), Takahiro Horie (337141), Takeshi Kimura (159578), Satoshi Koyama (784927), Koji Hasegawa (337158), Yutaka Suzuki (1379), Masahiro Kimura (2507551), Osamu Baba (634641), Naoya Sowa (634643), Yasuhiro Nakashima (825519), Ayako Suzuki (380214), Sijia Xu (3827086), Koh Ono (337143), Yugo Yamashita (822613)   +13 more
core   +1 more source

Prime Editing Exhibits Limited Genome-Wide Off-Target Effects in Cellular and Embryonic Gene Editing

Cells
Prime editing (PE) is a precise genome-editing technology that avoids double-strand breaks, holding great promise for clinical and agricultural applications.
Jitan Zheng, Mingdi Wu, Xueyan Wang, Zhenrui Zuo, Chikai Zhou, Erwei Zuo, Yangqing Lu   +6 more
doaj   +1 more source