Results 71 to 80 of about 14,685,807 (300)
, 2023 Off-targets of PPR56, PPR56|S4TN>TD and PPR56|S10TD>TN in the E.coli transcriptome summarized with Weblogo [89]. Consensus profiles were created from the sequences of 119, 382 and 15 C-to-U RNA editing off-targets, weighted with their respective editing ...
Jingchan Xie (16859288) +5 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben +4 more
wiley +1 more source
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down
SLAS DiscoveryIn this study we compare three methods for manipulating cell function: RNA interference (RNAi), CRISPR-Cas9 gene knock-out, and antibody-mediated loss-of-function.
Marie Buck-Wiese +3 more
doaj +1 more source
Intriguing Off-Target Effects of Ezetimibe
Journal of the American College of Cardiology, 2015 Tsujita et al. [(1)][1] report patients randomized to atorvastatin + ezetimibe therapy experienced a greater reduction in the percentage of atheroma volume than those randomized to atorvastatin, and it may be due to the lower mean low-density lipoprotein cholesterol achieved.
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk +10 more
wiley +1 more source
, 2019 Additional file 2: Figure S2. No off-target effects were found in all the offspring of mice that did not carry off-target locus. (A) PCR identifications of KI offspring of mice not carrying #1 off-target locus were validated by gel electrophoresis.
Junchao Dong (7582535) +4 more
core +1 more source
The impact of Relative Prevalence on dual-target search for threat items from airport X-ray screening [PDF]
, 2010 The probability of target presentation in visual search tasks influences target detection performance: thisis known as the prevalence effect (Wolfe et al., 2005).
Cave, K.R. +11 more
core +1 more source
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
A novel ROCK inhibitor: off-target effects of metformin
TURKISH JOURNAL OF BIOLOGY, 2021 In drug discovery, most small molecules cannot cross many stages, only a few can become drug candidates. Once the drug molecule is approved and marketed, nontarget effects that are not easily distinguishable from the actual target of the drugs might be evaluated. This situation restricts the treatment.
Aysun ÖZDEMİR, Mustafa ARK
openaire +3 more sources
Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target
, 2022 This dataset contains the untargeted lipidomics data for the publication Lechner et al. 2022 "Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target". The dataset has also been submitted to MetaboLight repository with ID
Severin Lechner, Guillaume Médard
core +1 more source