Results 61 to 70 of about 14,685,807 (300)

Chemical Modifications Rescue Off-Target Effects of RNAi [PDF]

ACS Chemical Biology, 2006
RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.
Ola, Snøve, John J, Rossi
openaire   +2 more sources

Serotonin-releasing agents with reduced off-target effects

Molecular Psychiatry, 2022
Abstract Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g. social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studies established the potential of drugs inducing the release of 5-HT via the 5-HT-transporter ...
Felix P Mayer, Marco Niello, Daniela Cintulova, Spyridon Sideromenos, Julian Maier, Yang Li, Simon Bulling, Oliver Kudlacek, Klaus Schicker, Hideki Iwamoto, Fei Deng, Jinxia Wang, Marion Holy, Rani Katamish, Walter Sandtner, Yulong Li, Daniela Pollak, Randy D Blakely, Marko Mihovilovic, Michael H Baumann, Harald H Sitte   +20 more
openaire   +2 more sources

Seed and non-seed region-dependent off-target effect analyses for siVIM-270 and siVIM-805.

, 2015
(A, B) Expression profiles of off-target genes with 3’UTR sequences that perfectly match the corresponding siRNA seed region (i.e. off-targets) were compared to genes without such sequence. (C, D) The correlation between GC content in all the subsections
Tomoko Takahashi (409474), Paul A. Wilson (826326), Yuko Nakano (836788), Piotr J. Kamola (116079), Kumiko Ui-Tei (10014)   +4 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

A computational study of off-target effects of RNA interference [PDF]

Nucleic Acids Research, 2005
RNA interference (RNAi) is an intracellular mechanism for post-transcriptional gene silencing that is frequently used to study gene function. RNAi is initiated by short interfering RNA (siRNA) of approximately 21 nt in length, either generated from the double-stranded RNA (dsRNA) by using the enzyme Dicer or introduced experimentally.
Qiu, Shibin, Adema, Coen M., Lane, Terran   +2 more
openaire   +2 more sources

Off-target evaluation of polyamide 2.

, 2019
(A) Correlations between changes in expression (logFC) after treatment of 10 nM of polyamide 2 against DMSO across ME180, CaSki and SiHA cells; numerical values above each pairing indicate the pairwise Spearman’s rank correlation coefficient.
Hiroki Nagase (734602), Takayoshi Watanabe (734601), Sakthisri Krishnamurthy (6569657), Atsushi Takatori (505352), Hiroyuki Yoda (4220626), Yoshinao Shinozaki (1971640), Nobuko Koshikawa (3307962), Jason Lin (2081266), Paul Horton (275835)   +8 more
core   +1 more source

Predicting unintended effects of drugs based on off-target tissue effects [PDF]

, 2016
Unintended effects of drugs can be caused by various mechanisms. Conventional analysis of unintended effects has focused on the target proteins of drugs.
Kim, Docyong, Lee, J., 이선재, Lee, Jaehyun, Lee, Doheon, Kim, D., Park, J., Lee, D., Park, Junseok, Lee, Sunjae,   +9 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Deviation from target debt ratio, cash flow imbalance and capital structure adjustment [PDF]

تحقیقات مالی, 2016
Most of capital structure researches have been conducted on the two dominant theories: trade-off and pecking order. Based on the trade-off theory, every firm has a target capital structure, while pecking order theory assumes that there is no target ...
Maryam Davallou, Alireza Rezaeian
doaj   +1 more source

Off-Target Cannabinoid Effects Mediated by GPR55 [PDF]

Pharmacology, 2012
Given the vast therapeutic potential of the endocannabinoid system, the revelation of a novel cannabinoid-sensitive target was treated with great excitement. The orphan G-protein coupled receptor 55 (GPR55) was initially touted as a novel cannabinoid target in early industrial patent literature.
openaire   +3 more sources