Results 61 to 70 of about 13,860,386 (295)
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Off-target evaluation of polyamide 2.
, 2019 (A) Correlations between changes in expression (logFC) after treatment of 10 nM of polyamide 2 against DMSO across ME180, CaSki and SiHA cells; numerical values above each pairing indicate the pairwise Spearman’s rank correlation coefficient.
Hiroki Nagase (734602) +8 more
core +1 more source
Chemical Modifications Rescue Off-Target Effects of RNAi [PDF]
ACS Chemical Biology, 2006 RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.
Ola, Snøve, John J, Rossi
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom +15 more
wiley +1 more source
Deviation from target debt ratio, cash flow imbalance and capital structure adjustment [PDF]
تحقیقات مالی, 2016 Most of capital structure researches have been conducted on the two dominant theories: trade-off and pecking order. Based on the trade-off theory, every firm has a target capital structure, while pecking order theory assumes that there is no target ...
Maryam Davallou, Alireza Rezaeian
doaj +1 more source
Intriguing Off-Target Effects of Ezetimibe
Journal of the American College of Cardiology, 2015 Tsujita et al. [(1)][1] report patients randomized to atorvastatin + ezetimibe therapy experienced a greater reduction in the percentage of atheroma volume than those randomized to atorvastatin, and it may be due to the lower mean low-density lipoprotein cholesterol achieved.
openaire +2 more sources
Off-target effects of carfilzomib that cause cardiotoxicity [PDF]
Blood, 2019 In this issue of Blood, Efentakis et al report using an animal model to study carfilzomib (Cfz)–induced cardiotoxicity and to demonstrate that the molecular mechanism is not related to the inhibition of the proteasome function but instead has an influence on modulation of the autophagy pathway, inactivation of AMPKα, and upregulation of PP2A ...
openaire +2 more sources
A computational study of off-target effects of RNA interference [PDF]
Nucleic Acids Research, 2005 RNA interference (RNAi) is an intracellular mechanism for post-transcriptional gene silencing that is frequently used to study gene function. RNAi is initiated by short interfering RNA (siRNA) of approximately 21 nt in length, either generated from the double-stranded RNA (dsRNA) by using the enzyme Dicer or introduced experimentally.
Qiu, Shibin +2 more
openaire +2 more sources
Off-target effects in CRISPR/Cas9 gene editing
Frontiers in Bioengineering and Biotechnology, 2023 Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene editing has become efficient, convenient and programmable, leading to promising translational studies and clinical trials for both ...
Congting Guo +7 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source