Results 51 to 60 of about 14,685,807 (300)
5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis
Frontiers in Pharmacology, 2010 Leukotrienes (LTs) constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate and colorectal ...
Dieter eSteinhilber +6 more
doaj +1 more source
The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges
Cellular & Molecular Biology Letters, 2022 MicroRNAs (miRNAs), which were initially discovered in Caenorhabditis elegans, can regulate gene expression by recognizing cognate sequences and interfering with the transcriptional or translational machinery.
Fan Zhang, Yunxin Zhou, Junying Ding
doaj +1 more source
Off-target effects of carfilzomib that cause cardiotoxicity [PDF]
Blood, 2019 In this issue of Blood, Efentakis et al report using an animal model to study carfilzomib (Cfz)–induced cardiotoxicity and to demonstrate that the molecular mechanism is not related to the inhibition of the proteasome function but instead has an influence on modulation of the autophagy pathway, inactivation of AMPKα, and upregulation of PP2A ...
openaire +2 more sources
MoleculesGenome editing is a promising therapeutic strategy for genetic disorders by modifying the genome precisely, especially the CRISPR/Cas9 system. However, a major limitation of CRISPR/Cas9 in gene therapy is the biosafety issues caused by off-target effects.
Jiasong Chang +9 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
ARCHIVING, SECRECY AND OFF-SITE RESEARCH
, 2019 With: Cécile Boex, Leyla Dakhli, Omar Dewachi, Carolina Kobelinsky, Shourideh Molavi, William Walters, Shela Sheikh. See full abstracts below. Off-Site · "Archiving, secrecy and off-site research", A workshop of the ERC Off-Site - 9&10 September 2019 ...
Off-Site
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo +9 more
wiley +1 more source
Off-targets analysis of sgRNAs.
, 2019 Surveyor analysis of the top 5 predicted off-targets for each sgRNA used. Panel shows amplified sequence of target and 3 representative off-targets, non-treated and treated with T7 endonuclease I.
Elena Vuelta (6685883) +12 more
core +1 more source
Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine +17 more
wiley +1 more source
The off-target effects of nonspecific NK cells [PDF]
Blood, 2015 In this issue of Blood, Shah et al describe the onset of severe acute graft-versus-host disease (GVHD) in 5 of 9 patients who received infusions of ex vivo expanded donor natural killer (NK) cells after HLA-matched hematopoietic stem cell transplantation (HSCT).
openaire +2 more sources