Results 51 to 60 of about 13,860,386 (295)
Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases
Frontiers in Cell and Developmental Biology, 2018 In recent years, there has been accelerated growth of clustered regularly interspaced short palindromic repeats (CRISPR) genome surgery techniques. Genome surgery holds promise for diseases for which a cure currently does not exist.
Christine L. Xu +15 more
doaj +1 more source
, 2014 Supplemental file with off-target sequences obtained using primers designed to specifically amplify bacterial endosymbionts.
Robert W. Bryson (3259062)
core +1 more source
5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis
Frontiers in Pharmacology, 2010 Leukotrienes (LTs) constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate and colorectal ...
Dieter eSteinhilber +6 more
doaj +1 more source
ARCHIVING, SECRECY AND OFF-SITE RESEARCH
, 2019 With: Cécile Boex, Leyla Dakhli, Omar Dewachi, Carolina Kobelinsky, Shourideh Molavi, William Walters, Shela Sheikh. See full abstracts below. Off-Site · "Archiving, secrecy and off-site research", A workshop of the ERC Off-Site - 9&10 September 2019 ...
Off-Site
core +1 more source
THE IRANIAN REVOLUTION AND ITS AFTERMATH
, 2022 With: Kamran Matin, Shahrzad Mojab, Kaveh Ehsani, Nasser Mohajer, Naghmeh Sohrabi, Orkideh Behrouzan, Shokoufeh Sakhi, Bahar Majdzadeh, Omid Montazeri, Marie Ladier-Fouladi, Fatemeh Masjedi, Arang Keshavarzian, Ahmad Moradi, Yasmin Nadir, Natalia ...
Off-Site
core +1 more source
MoleculesGenome editing is a promising therapeutic strategy for genetic disorders by modifying the genome precisely, especially the CRISPR/Cas9 system. However, a major limitation of CRISPR/Cas9 in gene therapy is the biosafety issues caused by off-target effects.
Jiasong Chang +9 more
doaj +1 more source
The off-target effects of nonspecific NK cells [PDF]
Blood, 2015 In this issue of Blood, Shah et al describe the onset of severe acute graft-versus-host disease (GVHD) in 5 of 9 patients who received infusions of ex vivo expanded donor natural killer (NK) cells after HLA-matched hematopoietic stem cell transplantation (HSCT).
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
On-target and Off-target-based Toxicologic Effects [PDF]
Toxicologic Pathology, 2012 Adverse toxicologic effects are categorized as chemical-based, on-target, or off-target effects. Chemical-based toxicity is defined as toxicity that is related to the physicochemical characteristics of a compound and its effects on cellular organelles, membranes, and/or metabolic pathways.
openaire +2 more sources
Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source