Results 41 to 50 of about 13,860,386 (295)
Development of therapeutic-grade small interfering RNAs by chemical engineering
Frontiers in Genetics, 2012 Recent successes in clinical trials have provided important proof of concept that small interfering RNAs indeed constitute a new promising class of therapeutics.
Jesper Bertram Bramsen, Jørgen eKjems
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Molecular Therapy: Nucleic Acids, 2022 Genome editing in pluripotent stem cells (PSCs) using CRISPR technology holds great promise for therapeutic applications. Yet, it has been reported that Cas9-mediated cleavage could cause large deletions or rearrangements of DNA, and the selection of ...
Zhenwu Zhang +7 more
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Off-target prediction to p.Trp402* sgRNA by predictors and filter criterias.
, 2022 Graphic illustration of the off-target prediction to p.Trp402* sgRNA before and after the filtering steps. The image shows the number of sequences returned for each of the five predictors and the number of sequences after the filtering step following the
Ursula Matte (328018) +2 more
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The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges
Cellular & Molecular Biology Letters, 2022 MicroRNAs (miRNAs), which were initially discovered in Caenorhabditis elegans, can regulate gene expression by recognizing cognate sequences and interfering with the transcriptional or translational machinery.
Fan Zhang, Yunxin Zhou, Junying Ding
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Molecular Therapy: Nucleic Acids, 2023 Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are widely used as RNA interference (RNAi) reagents. Recently, truncated shRNAs that trigger RNAi in a Dicer-independent manner have been developed.
Atsushi Shibata +6 more
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Off-Target Effects of Antidepressants on Vascular Function and Structure [PDF]
Biomedicines, 2021 Depression emerges as a risk factor for cardiovascular disease, and it is thought that successful antidepressant treatment may reduce such a risk. Therefore, antidepressant treatment embodies a potential preventive measure to reduce cardiovascular events in patients with depression.
Anna Dimoula +7 more
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The impact of Relative Prevalence on dual-target search for threat items from airport X-ray screening [PDF]
, 2010 The probability of target presentation in visual search tasks influences target detection performance: thisis known as the prevalence effect (Wolfe et al., 2005).
Cave, K.R. +11 more
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Off-Target Effects of Mirabegron on Muscarinic Receptors
Future PharmacologyOlder adults with multiple diseases are likely to be prescribed multiple medications including anticholinergic agents, which are frequently prescribed to manage conditions such as overactive bladder and chronic obstructive pulmonary disease and Parkinson’
Shizuo Yamada +3 more
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, 2018 (A) The target site (T) and ten predicted off-target sites (OT) for sgRNA91/Cas9. OT1~OT10 represents 10 potential off-target sites, and T represents target site.
Hongming Yuan (2200930) +20 more
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Effect of polymorphic sites in off-target sequences in mismatches and indels amount.
, 2022 Effect of polymorphic sites in off-target sequences in mismatches and indels amount.
Ursula Matte (328018) +2 more
core +1 more source