Results 81 to 90 of about 14,327 (215)

Perforated Gastric Ulcer due to a Giant Trichobezoar: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT The term “trichobezoar” refers to foreign and indigestible material in the gastrointestinal tract, and it can indicate several underlying mental illnesses. A 38‐year‐old woman reported experiencing sudden intensive abdominal pain, along with a two‐month history of vomiting, nausea, exhaustion, and abdominal discomfort.
Raghad Samha, Fadi Tabara, Howida Daghestani, Kristin Alsalami, Marah Mansour, Yasmin Martini, Abdulsalam Koushe, Youmna Stitieh, Abdulrahman Almarzouki, Riad Alhamaidi   +9 more
wiley   +1 more source

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Background: There is an increasing interest in the role of astrocytes contributing to the intrinsic bioremediation of ischemic brain injury. The purpose of this study was to disclose the effects and mechanism of midazolam (MDZ) on the proliferation and ...
Li Liu, Qi You, Yingfeng Tu, Quanyi Li, Lihong Zheng, Xuan Li, Jing Gu, Guonian Wang   +7 more
doaj   +1 more source

Cystatin B Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting the JAK2/STAT3 Signaling Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Using experimental models of stroke, we demonstrate that Cystatin B (CSTB) alleviates brain injury following cerebral ischemia reperfusion. This protection is mediated by inhibiting the JAK2/STAT3 signaling pathway, which reduces neuroinflammation and neuronal apoptosis. Our findings highlight CSTB as a promising therapeutic target for ischemic stroke.
Gang Zhou, Fengjiao Hu, Ju Gao, Lei Wang, Xiangbo Wu, Yu Tian, Peng Zhang, Guangming Xia, Feng Wan, Jinhua Wang   +9 more
wiley   +1 more source

磷酸化Smad3在神经元样细胞氧糖剥夺中的表达变化

Zhongguo shiyan zhenduanxue, 2015
目的探讨磷酸化Smad3蛋白在神经元样PC12细胞氧糖剥夺中的表达变化。方法利用鼠神经生长因子（NGF）诱导大鼠嗜铬细胞瘤细胞（PC12）向神经元样细胞转化,应用无糖DMEM培养液联合连二亚硫酸钠（Na2S2O4）构建氧糖剥夺模型（oxygen-glucose deprivation,OGD）,体外模拟神经元缺血性损伤。MTT检测神经元样细胞OGD 0,3,6和12h存活率,Western blot检测OGD前后磷酸化Smad3蛋白表达。结果成功建立神经元样PC12细胞的OGD模型;OGD ...
徐仲航, 王一鸣, 王勇涛, 王姣琦, 何金婷, 莽靖, 邵延坤, 徐忠信   +7 more
doaj  

A Gap Analysis Framework for an Open Data Portal Assessment Based on Data Provision and Consumption Activities

Informatics
An Open Government Data (OGD) portal assessment is necessary to track and monitor the progress of the OGD initiative and to drive improvement. Although OGD benchmarks typically focus on assessing and ranking OGD portals, few have been developed ...
Sahaporn Sripramong, Chutiporn Anutariya, Patipat Tumsangthong, Theerawat Wutthitasarn, Marut Buranarach   +4 more
doaj   +1 more source

The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.

PLoS ONE, 2014
Purinergic P2X and P2Y receptors are broadly expressed on both neurons and glial cells in the central nervous system (CNS), including dentate gyrus (DG).
Giovanna Maraula, Daniele Lana, Elisabetta Coppi, Francesca Gentile, Tommaso Mello, Alessia Melani, Andrea Galli, Maria Grazia Giovannini, Felicita Pedata, Anna Maria Pugliese   +9 more
doaj   +1 more source

Apigenin Protects H9c2 Cells Against Oxygen–Glucose Deprivation/Reperfusion Injury by Regulating Autophagy via the HIF‐1α/miR‐20a Axis

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT As living standards improve and the population ages, cardiovascular disease poses a significant threat to human health. Apigenin, a flavonoid compound found in many fruits and vegetables native to warm climates, is named after celery because it is found in the highest concentrations in this plant.
Xiaoxu Zhao, Huihui Li, Yi Yuan, Qingwen Cao, Bo Yu, Wenshu Xue, Gongping Yu, Yao Wang, Xiulong Niu, Yue Wang   +9 more
wiley   +1 more source

Tanshinone IIA reduces AQP4 expression and astrocyte swelling after OGD/R by inhibiting the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis [PDF]

, 2022
Zhaohua Tang, Gang Yang, Zhengbu Liao, Feilan Chen, Song Chen, Wentao Wang, Gang Huo, Xiaochuan Sun, Xiaoshu Wang   +8 more
openalex   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Tracking the Evolution of OGD Portals: A Maturity Model [PDF]

, 2017
Since its inception, open government data (OGD) as a free re-useable object has attracted the interest of researchers and practitioners, civil servants, citizens and businesses for different reasons in each target group. This study was designed to aggregate the research outcomes and developments through the recent years towards illustrating the ...
Alexopoulos, Charalampos, Diamantopoulou, Vasiliki, Charalabidis, Yannis   +2 more
openaire   +2 more sources