Results 81 to 90 of about 27,515 (197)

Apigenin attenuates myocardial ischemia-reperfusion injury through miR-448/SIRT1 axis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Myocardial ischemia/reperfusion injury (MIRI) is the primary pathological injury following ischemic cardiomyocyte therapy, but there are few effective treatments available for MIRI. Apigenin (API) is an active ingredient of herbal medicine.
Chenchen Tian, Bo Yu, Yibo Liu, Zhipeng Diao, Yue Wang, Jianmei Zhou   +5 more
doaj   +1 more source

U.S. state and state capital open government data (OGD): A content examination and heuristic evaluation of data processing capabilities of OGD sites

Proceedings of the Association for Information Science and Technology, 2019
ABSTRACT This paper reports the results of a multi‐phased investigation into Open Government Data (OGD) sites in the United States. Upon searching and examining OGD sites by state and state capital, we outlined current OGD practice in the US.
Tang, Rong, Gregg, Will, Hirsh, Sandra, Hall, Elaine   +3 more
openaire   +2 more sources

Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP [PDF]

Scientific Reports, 2018
AbstractNecroptosis is an essential pathophysiological process in cerebral ischemia-related diseases. Therefore, targeting necroptosis may prevent cell death and provide a much-needed therapy. Ansiomycin is an inhibitor of protein synthesis which can also activate c-Jun N-terminal kinases.
Mi-bo Tang, Yu-sheng Li, Shao-hua Li, Yuan Cheng, Shuo Zhang, Hai-yang Luo, Cheng-yuan Mao, Zheng-wei Hu, Jonathan C. Schisler, Chang-he Shi, Yu-ming Xu   +10 more
openaire   +2 more sources

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

BMC Anesthesiology, 2017
Background The present study aims to investigate the protective effects of dexmedetomidine (DMED) on hypoxia ischemia injury induced by oxygen and glucose deprivation (OGD) in PC12 and primary neuronal cells. Methods PC12 cells exposed to OGD was used to
Ya-Jun Liu, Duan-Yu Wang, Yong-Jian Yang, Wei-Fu Lei   +3 more
doaj   +1 more source

Identification of miRNAs That Mediate Protective Functions of Anti-Cancer Drugs During White Matter Ischemic Injury

ASN Neuro, 2021
We have previously shown that two anti-cancer drugs, CX-4945 and MS-275, protect and preserve white matter (WM) architecture and improve functional recovery in a model of WM ischemic injury.
Selva Baltan, Ursula S. Sandau, Sylvain Brunet, Chinthasagar Bastian, Ajai Tripathi, Hung Nguyen, Helen Liu, Julie A. Saugstad, Yalda Zarnegarnia, Ranjan Dutta   +9 more
doaj   +1 more source

Increasing Trends of Minimal Residual Disease Measurement in Trials Focusing on Multiple Myeloma Treatment: A Systematic Analysis of Clinical Research Design From 2014 to 2025

European Journal of Haematology, EarlyView.
ABSTRACT Minimal residual disease (MRD) is a central biomarker in multiple myeloma (MM), offering unprecedented sensitivity for evaluating treatment efficacy and serving as a potential surrogate endpoint. We conducted a comprehensive analysis of clinical trials registered on ClinicalTrials.gov between 2014 and 2025.
Mimi Choon‐Quinones, George Dennis Obeng, Benjamin Asiedu‐Ayeh, Sampson Kawuo, Asmau Mohammed Tukur, Inusah Mohammed, Akosua Pokuaah Obeng, Jean‐Luc Harousseau, Anja Seckinger, Dirk Hose, Emmanuel Sarkodie, Attila Imre, Csanádi Marcell   +12 more
wiley   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Background: There is an increasing interest in the role of astrocytes contributing to the intrinsic bioremediation of ischemic brain injury. The purpose of this study was to disclose the effects and mechanism of midazolam (MDZ) on the proliferation and ...
Li Liu, Qi You, Yingfeng Tu, Quanyi Li, Lihong Zheng, Xuan Li, Jing Gu, Guonian Wang   +7 more
doaj   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source