Cancer Medicine, Volume 14, Issue 19, October 2025.ABSTRACT Background The MUTYH gene is involved in DNA repair and is known for MAP (MUTYH‐associated polyposis), an autosomal recessive disorder that predisposes individuals to colorectal cancer (CRC), with a lifetime risk ranging from 40% to 90%. Homozygosity or double heterozygosity (DH) for pathogenic variants (PVs) in MUTYH causes MAP, but several ...
Gemma Caliendo +9 more
wiley +1 more source
Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]
, 2017 Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D +1 more
core +1 more source
Small Structures, Volume 6, Issue 10, October 2025.Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou +8 more
wiley +1 more source
Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion [PDF]
, 2013 Trinucleotide repeat (TNR) expansion is responsible for numerous human neurodegenerative diseases. However, the underlying mechanisms remain unclear. Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and deletion by ...
Lai, Yanhao +5 more
core +1 more source
Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients
Molecular Cancer, 2009 Background The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas.
Habib Samy L
doaj +1 more source
Mitochondrial DNA Damage: Role of Ogg1 and Aconitase
, 2011 Mitochondria have a vital role in respiration-coupled energy production, amino acid and fatty acid metabolism, Fe2+/Ca2+ homeostasis and the integration of apoptotic signals that regulate cellular life and death (Babcock et al., 1997; Loeb et al., 2005; Taylor & Turnbull, 2005; Kroemer et al., 2007).
Liu, Gang, Kamp, David W.
openaire +3 more sources
XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) single nucleotide polymorphisms in cervical cancer risk [PDF]
, 2013 Human Papillomavirus (HPV) is the main cause of cervical cancer and its precursor lesions. Transformation may be induced by several mechanisms, including oncogene activation and genome instability.
A Roszak +34 more
core +2 more sources
A rendszeres fizikai terhelés hatása az oxidatív fehérje és DNS sérülés javítására. A prevenció egyik titka? = The effects of regular exercise on oxidative protein and DNA damage repair. Secret prevention? [PDF]
, 2007 A tervezett kutatási célt a pályázat segítségével sikerült megvalósítani, de az új ismeretek birtokában újabb ismeretlen jelenségekbe ütköztünk. Korábban kimutattuk, hogy a rendszeres testedzés csökkenti a DNS sérülés nagyságát a sejtmagban, s azt ...
Ogonovszky, Helga +2 more
core
Molecular regulation and analysis of neural stem and cancer cell characteristics [PDF]
, 2012 Every single cell within an organism is constantly facing the demanding task of preserving the integrity of its genomic material to secure proper function and clearance from disease.
Reis, Amilcar
core +1 more source
Iranian Journal of ParasitologyBackground: The interplay of OGG1, 8-Oxoguanine, and oxidative stress triggers the exaggerated release of cytokines during malaria, which worsens the outcome of the disease.
Abdullahi Samaila +8 more
doaj