Results 121 to 130 of about 11,397 (216)

Pseudomonas aeruginosa prise en flagrant délit de casse ! Pseudomonas aeruginosa caught in the act ! [PDF]

, 2013
International audienceDes armes qui attaquent le génome eucaryote de façon encore mystérieuse Pseudomonas aeruginosa est une bactérie pathogène opportuniste infectant principalement les individus aux défenses immunitaires affaiblies, les patients ayant ...
Elsen, Sylvie, Lemercier, Claudie
core   +3 more sources

Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases [PDF]

, 2017
Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication.
Hunziker, P., Jiricny, J., Lingaraju, G M., Sartori, A A., Winkler, F K.   +4 more
core  

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney [PDF]

, 2014
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA ...
Abolhassani, Nona, Allocca, Mariacarmela, Ayata, Cenk, Calvo, Jennifer A., Daneshmand, Ali, Ebrahimkhani, Mohammad Reza, Jhun, Iny, Mazumder, Aprotim, Muthupalani, Sureshkumar, Samson, Leona D   +9 more
core   +1 more source

Structural and Dynamic Features of the Recognition of 8-oxoguanosine Paired with an 8-oxoG-clamp by Human 8-oxoguanine-DNA Glycosylase

Current Issues in Molecular Biology
8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for its
Maria V. Lukina, Polina V. Zhdanova, Vladimir V. Koval   +2 more
doaj   +1 more source

Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1

Molecules, 2015
The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of
Tushar R. Mahajan, Mari Eknes Ytre-Arne, Pernille Strøm-Andersen, Bjørn Dalhus, Lise-Lotte Gundersen   +4 more
doaj   +1 more source

Reducing Interconnect Cost in NoC through Serialized Asynchronous Links

, 2007
This work investigates the application of serialization as a means of reducing the number of wires in NoC combined with asynchronous links in order to simplify the clocking of the link.
Al-Hashimi, B, Benini, L, D'Allesandro, C, Ogg, S, Valli, E, Yakovlev, A   +5 more
core   +1 more source

8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus.

PLoS Pathogens
Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections.
Lang Pan, Ke Wang, Wenjing Hao, Yaoyao Xue, Xu Zheng, Ritwika S Basu, Tapas K Hazra, Azharul Islam, Yashoda Hosakote, Bing Tian, Matthieu G Gagnon, Xueqing Ba, Istvan Boldogh   +12 more
doaj   +1 more source

Structural and topological phase transitions on the German Stock Exchange

, 2013
We find numerical and empirical evidence for dynamical, structural and topological phase transitions on the (German) Frankfurt Stock Exchange (FSE) in the temporal vicinity of the worldwide financial crash. Using the Minimal Spanning Tree (MST) technique,
Gubiec, T., Kutner, R., Sienkiewicz, A., Struzik, Z. R., Wiliński, M.   +4 more
core   +1 more source

Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy

Molecular Medicine
Background 8-Oxoguanine DNA glycosylase (OGG1), a well-known DNA repair enzyme, has been demonstrated to promote lung fibrosis, while the specific regulatory mechanism of OGG1 during pulmonary fibrosis remains unclarified.
Wenjuan Wu, Hongxia Jia, Song Chen, Xinran Ma, Shuai Zhou, Lingxiao Qiu, Xinhui Wu, Ping Li, Heying Chu, Guojun Zhang   +9 more
doaj   +1 more source

Evaluation of 8-Oxoguanine DNA Glycosylase-1(OGG1) Serum Levels in Patients with Type2 Diabetes Mellitus

Wasit Journal for Pure Sciences
: Chronic hyperglycemia in type 2 diabetes mellitus leads to elevated oxidative stress. As a consequence, the accumulation of reactive oxygen species (ROS)may cause additional damage to various biological macromolecules, including DNA. The current study
Duaa Hussein Allawi Al-dulaimi
doaj   +1 more source