Results 141 to 150 of about 5,940 (176)

Structure and chromosome location of human OGG1

Cytogenetic and Genome Research, 1999
OGG1 (alias MMH) encodes an 8-hydroxyguanine glycosylase, functionally homologous to bacterial mutM. Here, we report its genomic structure and fine chromosome location. The human OGG1 gene corresponding to the isoform 1 transcripts, consists of seven exons, spanning 7,421 bps, while an alternative additional exon, utilized for isoform 2, is located ...
T, Ishida, Y, Hippo, Y, Nakahori, I, Matsushita, T, Kodama, S, Nishimura, H, Aburatani   +6 more
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A functional OGG1 homologue from Arabidopsis thaliana

Molecular Genetics and Genomics, 2001
One of the major mutagenic base lesions in DNA caused by exposure to reactive oxygen species is 7,8-dihydro-8-oxoguanine (8-oxoG). Genes coding for DNA repair enzymes that recognise 8-oxoG have been reported in bacteria, yeast, mammals and plants. The prokaryotic and eukaryotic genes are functional homologues but differ in their primary sequence.
A L, Dany, A, Tissier
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Tuberin regulates the DNA repair enzyme OGG1

American Journal of Physiology-Renal Physiology, 2008
The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. The TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. We investigated a potential role for tuberin in regulating a key DNA repair pathway.
Samy L, Habib, Daniel J, Riley, Lenin, Mahimainathan, Basant, Bhandari, Goutam Ghosh, Choudhury, Hanna E, Abboud   +5 more
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OGG1 is essential in oxidative stress induced DNA demethylation

Cellular Signalling, 2016
DNA demethylation is an essential cellular activity to regulate gene expression; however, the mechanism that triggers DNA demethylation remains unknown. Furthermore, DNA demethylation was recently demonstrated to be induced by oxidative stress without a clear molecular mechanism.
Xiaolong, Zhou, Ziheng, Zhuang, Wentao, Wang, Lingfeng, He, Huan, Wu, Yan, Cao, Feiyan, Pan, Jing, Zhao, Zhigang, Hu, Chandra, Sekhar, Zhigang, Guo   +10 more
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XPC deficiency is related to APE1 and OGG1 expression and function

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2016
Oxidative DNA damage is considered to be a major cause of neurodegeneration and internal tumors observed in syndromes that result from nucleotide excision repair (NER) deficiencies, such as Xeroderma Pigmentosum (XP) and Cockayne Syndrome (CS). Recent evidence has shown that NER aids in removing oxidized DNA damage and may interact with base excision ...
Julliane Tamara Araújo de Melo, Ana Rafaela de Souza Timoteo, Tirzah Braz Petta Lajus, Juliana Alves Brandão, Nadja Cristhina de Souza-Pinto, Carlos Frederico Martins Menck, Anna Campalans, J. Pablo Radicella, Alexandre Teixeira Vessoni, Alysson Renato Muotri, Lucymara Fassarella Agnez-Lima   +10 more
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Oxidative damage to purines in DNA: Role of mammalian Ogg1

DNA Repair, 2007
DNA damage caused by reactive oxygen species is ubiquitous to all living organisms. More than 60 different base lesions have been identified, and the majority of these are removed via the base excision repair pathway. This pathway appears to represent a highly conserved and ancient mechanism of defence counteracting spontaneous DNA decay.
Arne, Klungland, Svein, Bjelland
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Enzyme Kinetics of an Alternative Splicing Isoform of Mitochondrial 8‐Oxoguanine DNA Glycosylase, OGG1‐1b, and Compared with the Nuclear OGG1‐1a

Journal of Biochemical and Molecular Toxicology, 2014
ABSTRACTEight alternatively spliced isoforms of human 8‐oxoguanine DNA glycosylase (OGG1) (OGG1‐1a to ‐1c and ‐2a to ‐2e) are registered in the National Center for Biotechnology Information. OGG1(s) in mitochondria have not yet been fully characterized biochemically.
Akira, Ogawa, Takashi, Watanabe, Sayaka, Shoji, Chie, Furihata   +3 more
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Abstract 15768: Mitochondria-Targeted DNA Repair Glycosylase Ogg1 Suppresses Early Stage of Atherogenesis in Ogg1 Deficient Mice

Circulation, 2014
Introduction: Reactive oxygen species (ROS) play a key role in the development of atherosclerosis. Mitochondria are a main source of endogenous ROS in the cell. Mitochondrial DNA (mtDNA) is sensitive to oxidation and our previous results from cultured cell and intact animal models suggest that increasing mtDNA repair prevents ...
Mykhaylo V Ruchko, Sergiy Sukhanov, Olena M Gorodnya, Lyudmila I Rachek, Svitlana D Danchuk, Patrick Delafontaine, Mark N Gillespie   +6 more
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The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases

Expert Opinion on Therapeutic Targets
Pulmonary diseases impose a daunting burden on healthcare systems and societies. Current treatment approaches primarily address symptoms, underscoring the urgency for the development of innovative pharmaceutical solutions. A noteworthy focus lies in targeting enzymes recognizing oxidatively modified DNA bases within gene regulatory elements, given ...
Lang, Pan, Istvan, Boldogh
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Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM

Biochemical and Biophysical Research Communications, 2009
The association of the Ser326Cys polymorphism of the 8-oxoguanine glycosylase 1 (OGG1) gene with type 2 diabetes was examined using a Japanese population (n (M/W): 4585 (2085/2500); age: 62.6 +/- 10.9 years). HbA1c levels and frequency of diabetic subjects were significantly higher in subjects with genotypes with Cys allele than in those without (p = 0.
Makoto, Daimon, Toshihide, Oizumi, Sayumi, Toriyama, Shigeru, Karasawa, Yumi, Jimbu, Kiriko, Wada, Wataru, Kameda, Shinji, Susa, Masaaki, Muramatsu, Isao, Kubota, Sumio, Kawata, Takeo, Kato   +11 more
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