Results 151 to 160 of about 5,940 (176)

OGG1: From Structural Analysis to the Knockout Mouse

2007
Among the four DNA bases, guanine, having the lowest redox potential, is the most susceptible to oxidation, and among the oxidized bases 7,8-dihydro-8-oxoguanine (8-oxoG) is certainly the lesion that has retained most attention over many years. This altered base can pair with A as well as C residues during replication.
Arne Klungland, Jon K. Laerdahl, Torbjørn Rognes   +2 more
openaire   +1 more source

[Repair of oxidized guanine in mammals: OGG1 genes].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1998
This paper reviews the present state of the studies on the repair of a major oxydative lesion on DNA, the 8-oxo-guanine (8-OxoG). This modified base has been proved to be highly mutagenic and therefore implicated in the ethiology of several pathologies.
J P, Radicella, S, Boiteux
openaire   +1 more source

OGG1 Gene

2020
openaire   +1 more source

Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

FASEB Journal, 2020
Min Wei, István Boldogh, Xueqing Ba
exaly  

Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine

DNA Repair, 2023
Anna Campalans, Sébastien Huet, Yvan Canitrot   +2 more
exaly  

The GO Repair Pathway: OGG1 and MUTYH

2016
Amelia H. Manlove, Nicole N. Nuñez, Sheila S. David   +2 more
openaire   +1 more source

OGG1 inhibition as combination treatment for cancer therapy

2016
Novel anticancer therapies are needed to overcome drug resistance of chemotherapeutic drugs leading to tumor relapse. Combination therapy with target-specific drugs underlies great potential to increase the efficiency of chemotherapy. Increased DNA repair capacity is one of the resistance mechanism of chemotherapy drug cisplatin.
openaire   +1 more source

OGG1 at the Crossroads Between Repair and Transcriptional Regulation

2023
Anne-Marie Di Guilmi, Nuria Fonknechten, Anna Campalans   +2 more
openaire   +1 more source

OGG1 deletion inhibites the glycolytic pathway of cardiomyocytes

Diabetes is the most common metabolic disease worldwide, and Diabetic Cardiomyopathy (DCM) is a severe complication of diabetes. Energy metabolism disruption is a key factor in the development of DCM and subsequent heart failure. It is well known that changes in glucose metabolism can lead to severe disruptions in lipid, amino acid, and energy ...
openaire   +1 more source

An active alternative splicing isoform of human mitochondrial 8-oxoguanine DNA glycosylase (OGG1)

Genes and Environment, 2015
Chie Furihata
exaly