Results 61 to 70 of about 11,397 (216)

Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors

Molecular Cancer, 2008
Background Tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors. Loss of heterozygosity (LOH) at the TSC2 locus has
Habib Samy L, Simone Simona, Barnes Jeff J, Abboud Hanna E   +3 more
doaj   +1 more source

XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. [PDF]

, 2010
PurposeEpidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage.
Chen, Pei-Liang, Cheng, Ya-Wen, Koeh, Hank, Lee, Huei, Liu, Yu-Ling, Tsai, Yi-Yu, Yeh, Kun-Tu   +6 more
core   +1 more source

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair [PDF]

, 2015
Base excision repair (BER) of an oxidized base within a trinucleotide repeat (TNR) tract can lead to TNR expansions that are associated with over 40 human neurodegenerative diseases.
Beaver, Jill M., Casin, Astrid H., Lai, Yanhao, Laverde, Eduardo E., Liu, Yuan, Xu, Meng   +5 more
core   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells [PDF]

, 2008
Biological systems are frequently exposed to excessive reactive oxygen species, causing a disturbance in the cells natural antioxidant defence systems and resulting in damage to all biomolecules, including nucleic acids.
Coutinho, O. P., Gomes, A. C., Silva, João P.   +2 more
core   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Phosphorylation of human oxoguanine DNA glycosylase ( -OGG1) modulates its function [PDF]

Nucleic Acids Research, 2005
Oxoguanine DNA glycosylase (OGG1) initiates the repair of 8-oxoguanine (8-oxoG), a major oxidative DNA base modification that has been directly implicated in cancer and aging. OGG1 functions in the base excision repair pathway, for which a molecular hand-off mechanism has been proposed.
Hu, Jingping, Imam, Syed Z., Hashiguchi, Kazunari, de Souza-Pinto, Nadja C., Bohr, Vilhelm A.   +4 more
openaire   +2 more sources

APE1 Activity is Controlled by Non‐G‐Quadruplex Conformations in Single‐ and Double‐Stranded G‐Quadruplex Constructs

Chemistry – A European Journal, Volume 32, Issue 5, 2 February 2026.
G‐quadruplex (G4) folding in DNA is inhibitory to AP endonuclease, although the protein still binds well to G4s. Curiously, partially folded G‐rich sequences, possibly transient hairpins, containing AP are very good substrates for cleavage by APE1. Herein, the enzyme activity and G4 folding are studied in single‐stranded vs. duplex contexts.
Brianna L. Trabucco, Aaron M. Fleming, Cynthia J. Burrows   +2 more
wiley   +1 more source

PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.

PLoS ONE, 2014
The ethiology of colon cancer is largely dependent on inflammation driven oxidative stress. The analysis of 8-oxodeoxyguanosine (8-oxodGuo) level in leukocyte DNA of healthy controls (138 individuals), patients with benign adenomas (AD, 137 individuals ...
Tomasz Dziaman, Hubert Ludwiczak, Jaroslaw M Ciesla, Zbigniew Banaszkiewicz, Alicja Winczura, Mateusz Chmielarczyk, Ewa Wisniewska, Andrzej Marszalek, Barbara Tudek, Ryszard Olinski   +9 more
doaj   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source