Results 81 to 90 of about 11,397 (216)

Catalytic activity of OGG1 is impaired by Zinc deficiency

DNA Repair
Oxidative stress-induced DNA base modifications, if unrepaired, can increase mutagenesis and genomic instability, ultimately leading to cell death. Cells predominantly use the base excision repair (BER) pathway to repair oxidatively-induced non-helix distorting lesions.
Priyanka, Sharma, Carmen P, Wong, Emily, Ho, Harini, Sampath   +3 more
openaire   +2 more sources

Ogg1 -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis [PDF]

Circulation Research, 2016
Rationale: Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as an important component of inflammatory processes in atherosclerosis.
Tumurkhuu, Gantsetseg, Shimada, Kenichi, Dagvadorj, Jargalsaikhan, Crother, Timothy R, Zhang, Wenxuan, Luthringer, Daniel, Gottlieb, Roberta A, Chen, Shuang, Arditi, Moshe   +8 more
openaire   +4 more sources

Isolation of a novel quercetin derivative from Terminalia chebula and RT-PCR-assisted probing to investigate its DNA repair in hepatoma cells

Research in Pharmaceutical Sciences
Background and purpose: DNA damage can lead to carcinogenesis if replication proceeds without proper repair. This study focused on the purification of a novel quercetin derivative present in Terminalia chebula fruit and studied its protective role in ...
Kallyadan Soumya, Karickal Raman Haridas, Jesna James, Sudhakaran Sudheesh   +3 more
doaj   +1 more source

MiR-4673 Modulates Paclitaxel-Induced Oxidative Stress and Loss of Mitochondrial Membrane Potential by Targeting 8-Oxoguanine-DNA Glycosylase-1

Cellular Physiology and Biochemistry, 2017
Background: Our previous study identified a novel microRNA, miR-4673, which is upregulated in A549 cells exposed to paclitaxel (PTX). In this study, we investigated the role of miR-4673 in PTX-induced cytotoxicity. Methods: 3-(4,5-dimethylthiazol-2-yl)-2,
Hai-Li Huang, Ya-Peng Shi, Hui-Juan He, Ya-Hong Wang, Ting Chen, La-Wei Yang, Teng Yang, Jie Chen, Jun Cao, Wei-Min Yao, Gang Liu   +10 more
doaj   +1 more source

Expression variation of OGG1 and HPRT gene and DNA damage in arsenic exposed industrial workers.

PLoS ONE, 2022
Arsenic exposure alters redox balance, induces DNA damage, and deregulates many genes. OGG1 gene involved in base repair mechanism, for excision of 8-oxoguanine (8-oxoG) from DNA formed as a result of accumulation of ROS in cell.
Zertashia Akram, Ishrat Mahjabeen, Muhammad Umair, Muhammad Fahim, Mahmood Akhter Kayani, Lulu Fatima, Malik Waqar Ahmad, Sarwat Jahan, Tayyaba Afsar, Ali Almajwal, Nawaf W Alruwaili, Iftikhar Ali Khawar, Suhail Razak   +12 more
doaj   +1 more source

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

BioEssays, Volume 48, Issue 1, January 2026.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source

The Role of DNA Repair Glycosylase OGG1 in Intrahepatic Cholangiocarcinoma [PDF]

Anticancer Research, 2019
The effects of oxidative stress on various carcinomas were reported in previous studies, but those in intrahepatic cholangiocarcinoma (ICC) have not been fully elucidated. The purpose of this study was, thus, to reveal the effects of oxidative DNA damage and repair enzymes on ICC.The levels of 8-hydroxydeoxyguanosine (8-OHdG) and 8-OHdG DNA glycosylase
Kazuhito, Sakata, Tomoharu, Yoshizumi, Takuma, Izumi, Masahiro, Shimokawa, Shinji, Itoh, Toru, Ikegami, Noboru, Harada, Takeo, Toshima, Yohei, Mano, Masaki, Mori   +9 more
openaire   +2 more sources

Whole genomic hot spot analysis of DNA base damage in non-small cell lung cancer cells based on ChIP-seq technique

Di-san junyi daxue xuebao, 2021
Objective To establish a method that can be used to analyze the distribution of DNA base damage sites at the genome-wide level, and use this method to analyze the distribution pattern of DNA base damage hotspots in non-small cell lung cancer cell line ...
LI Shixun, CHENG Yi, DAI Nan, XIONG Yanli, LI Mengxia   +4 more
doaj   +1 more source

Role of estrogen and other sex hormones in brain aging: Neuroprotection and DNA repair [PDF]

, 2017
Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due ...
Gredilla, Ricardo, Stevnsner, Tinna, Zarate, Sandra Cristina   +2 more
core   +1 more source

8‐Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin‐Induced Cardiac Dysfunction

Oxidative Medicine and Cellular Longevity, 2022
Doxorubicin is an anthracycline widely used for the treatment of various cancers; however, the drug has a common deleterious side effect, namely a dose‐dependent cardiotoxicity. Doxorubicin treatment increases the generation of reactive oxygen species, which leads to oxidative stress in the cardiac cells and ultimately DNA damage and cell death.
Chukwuemeka George Anene-Nzelu, Peter Yiqing Li, Tuan Danh Anh Luu, Shi Ling Ng, Zenia Tiang, Bangfen Pan, Wilson Lek Wen Tan, Matthew Ackers-Johnson, Ching Kit Chen, Yee Phong Lim, Rina Wang Miao Qin, Wee Woon Chua, Lim Xin Yi, Roger Sik-Yin Foo, Yusaku Nakabeppu   +14 more
openaire   +2 more sources